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Novel application of deoxyrhaponticin

A technology of deoxygenated emodin and its application, which can be applied in the directions of medical preparations containing active ingredients, applications, animal feeds, etc., and can solve the problems of lack of anti-coccidial drugs, reduced effect of anti-coccidial drugs, etc.

Pending Publication Date: 2021-06-04
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The prevention and treatment of chicken coccidiosis depends on the use of anticoccidial drugs. With the emergence of clinical wild poisonous strains resistant to traditional anticoccidial drugs, the effect of the original anticoccidial drugs is significantly reduced, making the lack of clinically effective drugs. Anticoccidiostats with clear therapeutic effect

Method used

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  • Novel application of deoxyrhaponticin
  • Novel application of deoxyrhaponticin
  • Novel application of deoxyrhaponticin

Examples

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Effect test

Embodiment 1

[0058] The present embodiment provides the cell level test of deoxyterraein, specifically as follows:

[0059] 1. Experimental materials:

[0060] (1) Drugs: Deoxyterretherin and sodium sulfachlorpyrazine were purchased from Merck.

[0061] (2) Coccidia oocysts: sporulated oocysts of Eimeria tenella (E. tenella) Guangdong strain, preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences, and rejuvenated in coccidia-free chicks before use.

[0062] (3) Cells: MDBK cells (ie, bovine kidney cells), preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences.

[0063] 2. Experimental method:

[0064] In this embodiment, the E.tenella MDBK cell culture model is used to evaluate the anti-Eimeria tenella (E.tenella) effect, and the specific evaluation steps include:

[0065] (1) Digest the MDBK cells growing to a fusion state of more than 80% with 0.25% trypsin digestion solution, and use 4×10 5 Plate 12-well cell culture ...

Embodiment 2

[0093]The present embodiment provides the animal level test of deoxyterraein, specifically as follows:

[0094] 1. Experimental materials:

[0095] (1) Preparation of deoxyrhein powder: take 1.5 g of deoxyrhein (not less than 80%) and 98.5 g of starch and mix them evenly.

[0096] (2) Control drug: conventional anticoccidial drug Sanzi coccidian powder (30% sodium sulfachlorpyrazine), produced by Shanghai Novartis Animal Health Co., Ltd.

[0097] (3) Coccidia oocysts: sporulated oocysts of Eimeria tenella (E. tenella) Guangdong strain, preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences, and rejuvenated in coccidia-free chicks before use.

[0098] (4) Chicks: Lingnan yellow broiler chickens, provided by the Institute of Animal Science, Guangdong Academy of Agricultural Sciences, were raised in a sterilized special animal room; the chicken cages and utensils were strictly sterilized, free to eat and drink pure water; observe before the test ...

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Abstract

The invention relates to the technical field of animal disease prevention and control, and particularly relates to novel application of deoxyrhaponticin, and specifically relates to application of deoxyrhaponticin in preparation of anti-coccidiosis drugs or feed. Compared with the prior art, the invention has the following beneficial effects: deoxyrhaponticin is found to have an obvious inhibitory effect on coccidium, the inhibitory effect is reflected in that deoxyrhaponticin can effectively inhibit the reproduction of Eimeria on a cell culture model of Eimeria, and the inhibitory effect is verified by animal experiments. Aiming at the discovery of deoxyrhaponticin, the application field of deoxyrhaponticin is broadened, and a new scheme is provided for the development of anti-coccidiosis drugs.

Description

technical field [0001] The invention relates to the technical field of animal disease prevention and control, in particular to a new application of deoxyrhein. Background technique [0002] Deoxyrhein, also known as deoxyrhein, has a molecular weight of 404.41 and a CAS number of 30197-14-9. 21 h 24 o 8 , the chemical structure is as follows: [0003] [0004] Deoxyrhein is mainly derived from the Polygonaceae plant of Rhubarb Tianshan, and it is a symmetrical stilbene glycoside. [0005] Existing studies have shown that deoxyterraein has antibacterial and antioxidant effects. According to reports, the functions of deoxyterreetin include lowering blood fat, lowering blood sugar, anti-tumor, anti-thrombosis, inhibiting allergic reactions, improving microcirculation and enhancing immunity of the body. [0006] Chicken coccidiosis is a disease caused by infection with one or more species of Eimeria coccidia, which are Apicomplexa, Sporozoa, Eucoccidiidae, Eimeriaceae, E...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P33/02A23K50/75A23K10/30
CPCA61K31/7034A61P33/02A23K50/75A23K10/30
Inventor 孙铭飞廖申权戚南山林栩慧吕敏娜吴彩艳李娟蔡海明胡俊菁肖文婉于林增张小慧张健騑谢明权
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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