Anti-inflammatory tryptophan enema preparation as well as preparation method and application thereof

A tryptophan and preparation technology, applied in the field of medicine, can solve the problems of not being able to completely and effectively control the development of inflammation and affecting the quality of life of patients

Pending Publication Date: 2021-06-01
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main clinical treatment methods are still nutrition therapy, drug therapy, monoclonal antibody-related biological therapy, and immunosuppressant therapy. However, in practice, these therapies cannot completely and effectively control the development of inflammation, and some patients often develop to A stage requiring surgical intervention that seriously affects the patient's quality of life

Method used

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  • Anti-inflammatory tryptophan enema preparation as well as preparation method and application thereof
  • Anti-inflammatory tryptophan enema preparation as well as preparation method and application thereof
  • Anti-inflammatory tryptophan enema preparation as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0087] 1. Dextran sodium sulfate (DSS) modeling and animal grouping

[0088] C57BL / 6 female mice were modeled after two weeks of adaptive feeding (six weeks old). Control group: normal drinking water, lasted for 7 days and then killed; model group: 2.5% DSS drinking water, continued for 7 days, and the mice were replaced with DSS drinking water every 2-3 days during the water feeding stage. Trp intervention group: 2.5% DSS drinking water, continued for 7 days, the DSS drinking water of mice was replaced every 2-3 days during the water feeding stage, and Trp enema intervention was carried out on the 2nd, 4th, and 6th day of the experiment (the specific process is as follows: figure 1 shown);

[0089] DSS was purchased from Meiwei MP Biomedical Company, and was prepared with double-distilled water to make 2.5% DSS solution; use a 0.22 μm filter to remove impurities and bacteria, and prepare and use immediately;

[0090] During the experiment, observe and record the general con...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to an anti-inflammatory tryptophan (Trp) enema preparation and a preparation method and application thereof.In-vivo and in-vitro experiments prove that after intervention, the tryptophan enema preparation can effectively improve clinical symptoms of colitis such as weight loss, diarrhea and hematochezia of experimental animals, relieve pathological damage of colon tissue, and is capable of inhibiting inflammatory cells of experimental mice from infiltrating colon tissues, and experimental results prove that the tryptophan enema preparation has good anti-inflammatory immunosuppressive activity and high safety, can be used for preparing medicines for clinically treating inflammatory bowel diseases, and has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a novel anti-inflammatory tryptophan enema and its preparation method and application, in particular to the use of tryptophan (Trp) in the preparation of drugs for inhibiting local intestinal inflammation in inflammatory bowel disease use in . Background technique [0002] Studies have shown that inflammatory bowel disease (Inflammatory bowel disease, IBD) is an inflammatory disease characterized by intestinal immune system disorders and can involve different parts of the digestive tract. The disease has the characteristics of recurrent attacks, and its mechanism has not been fully understood . In clinical practice, the disease is mainly divided into two different types, namely, ulcerative colitis (Ulcerative colitis, UC) and Crohn's disease (Crohn disease, CD). In recent years, the incidence of this disease has increased significantly, and there is a trend of gradually getting ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/405A61P1/00A61P1/04
CPCA61K31/405A61K9/08A61K9/0031A61P1/00A61P1/04
Inventor 刘杰骆菲菲宋欢陈琳罗忠光
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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