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Programmable intelligent controlled-release capsule as well as application and preparation method thereof

An intelligent controlled release and capsule technology, which is applied in the directions of non-active ingredient medical preparations, capsule delivery, pharmaceutical formulations, etc., can solve the problems of delayed release, immediate release, and poor shape of drug printing, and achieves reduction of processing procedures, shortening Processing cycle, the effect of simple process

Active Publication Date: 2021-05-28
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, although hydrogel drugs have been prepared by stereolithography, inkjet printing and extrusion molding 3D printing technologies, there are still many defects, such as poor drug printing shape, and sometimes the drug load needs to be passed through the hydrogel. The gel is soaked in the drug solution. The release mode of the drug is mainly delayed release and / or immediate release and / or constant release, and real-time intelligent controlled release cannot be achieved through in vivo environmental stimulation.

Method used

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  • Programmable intelligent controlled-release capsule as well as application and preparation method thereof
  • Programmable intelligent controlled-release capsule as well as application and preparation method thereof
  • Programmable intelligent controlled-release capsule as well as application and preparation method thereof

Examples

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preparation example Construction

[0040] The preparation method of the programmable intelligent controlled-release capsule provided by the present invention comprises the following steps:

[0041] Step 1, the shell material of the capsule and the drug of the pretreated inner core are respectively loaded into two slurry tubes of the 3D printing system as slurry;

[0042] Step 2, using modeling software to build a three-dimensional model of the capsule, and then transfer it to the 3D printing system after conversion by slicing software;

[0043] Step 3. Set the parameters and start the 3D printing system to accurately form the first layer of the capsule structure slice on the substrate, and then move the substrate upwards, and the moving height is the same as the layer thickness of the first layer. Print the second layer on the basis of the above, and repeat until the entire capsule structure is formed.

[0044] Step 4: curing the molded capsule structure to obtain a programmable and controlled-release intellig...

Embodiment 1

[0052] Embodiment 1: the preparation shell thickness is the capsule of 2mm

[0053] 1. Material preparation:

[0054] (1) Preparation of capsule shell material: add the above materials into 10ml according to the molar ratio of NIPAM:N,N-methylenebisacrylamide:α-ketoglutaric acid:NaOH=5000:1:5:125 Mix in pure water evenly, vacuum degass under stirring, then add 1.5% Carbomer 940 to the ink, after fully stirring, the shell printing ink for 3D printing is obtained;

[0055] (2) Pretreatment of the inner core drug: add the above materials into 10ml of pure water in the ratio of Brilliant Blue: NaOH=16:125 by molar ratio, mix evenly, vacuum degas under stirring, and then add 1.5% Carbomer to the ink 940, after fully stirring, obtain the medicinal printing ink that is used for 3D printing, here, bright blue is used as medicine model ( figure 1 mid-dark part).

[0056] 2. Preparation process

[0057] (1) First, use Solidworks software to establish a three-dimensional solid model ...

Embodiment 2

[0064] Embodiment 2: the preparation shell thickness is the capsule of 4mm

[0065] The steps of this example differ from Example 1 in that the thickness of the outer shell of the prepared capsule is 4 mm, and the drug size of the inner core is the same as that of Example 1.

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Abstract

The invention provides a programmable intelligent controlled-release capsule as well as application and a preparation method thereof. The capsule is of a shell-core type structure prepared through 3D printing, a shell of the capsule is hydrogel, and an inner core of the capsule is a medicine with a treatment effect. The capsule can respond in real time through in-vivo environment temperature stimulation, intelligent controlled release is achieved, the preparation process is simple, and personalized customization of specific individuals on the medicine is facilitated.

Description

technical field [0001] The invention belongs to the technical field of medicine and additive manufacturing, and in particular relates to a programmable intelligent controlled-release capsule and a preparation method thereof, and also relates to a new application of the capsule. Background technique [0002] An important problem with traditional oral drug delivery methods, such as tablets and capsules, is that the dose of the drug is fixed, and most drugs can only be used in a limited dose strength, requiring multiple doses. However, for the treatment of the same type of disease, the individual needs of different patients will be different. The demand for personalized medicines for specific individuals is increasing (in terms of dose strength and / or release time), and traditional drug delivery methods are not able to meet the needs of clinical applications, forcing the pharmaceutical industry to consider new methods of drug production. [0003] Hydrogel is a kind of extremel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/32B33Y80/00B33Y70/00C08F220/54C08F222/38C08J3/075G06T17/00G16C60/00C08L33/24
CPCA61K9/4816B33Y80/00B33Y70/00C08F220/54C08J3/075G06T17/00G16C60/00C08J2333/24C08F222/385
Inventor 张志辉祖硕刘庆萍王振国宋正义张爽
Owner JILIN UNIV
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