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Preparation method of empty capsule for targeted release in intestinal tract

A hollow capsule, targeting technology, applied in capsule delivery, medical preparations with inactive ingredients, pharmaceutical formulations, etc., can solve the problems of no anti-dissolution effect, low acceptance, cumbersome preparation process of hollow capsules, etc., and achieve exquisite structure. , high acceptance, excellent performance in various indicators and safety

Active Publication Date: 2021-05-25
玖洲胶囊生物制药(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vegetable enteric-coated capsules are resistant to gastric acid, but have no anti-dissolution effect on the mixed digestive juice in the intestine
Therefore, enteric-coated capsules will dissolve in the intestinal tract, while gastric-soluble capsules are not acid-resistant, so they will dissolve in the stomach. Therefore, we propose a hollow capsule for targeted release in the intestinal tract, and the preparation process of the hollow capsule is cumbersome, and the acceptance lower

Method used

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  • Preparation method of empty capsule for targeted release in intestinal tract
  • Preparation method of empty capsule for targeted release in intestinal tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In this example, a method for preparing hollow capsules for targeted release in the intestinal tract is proposed, which includes the following steps:

[0033] S1: Throwing tailings: according to the batch production instructions, after adding the measured purified water into the sol tank, turn on the stirring motor, then slowly add the weighed tailings into the sol tank, after stirring continuously, start to heat up;

[0034]S2: Heating up: Set the temperature controller at the desired temperature of 95°C, open the main steam valve, set the steam temperature to rise, open the steam electric control valve, steam enters through the upper interlayer pipe of the sol tank, flows out through the lower interlayer pipe, and then passes through After the output valve, it becomes condensed water and is discharged;

[0035] S3: Add raw materials and auxiliary materials and stir: when the temperature of the glue in the sol tank is heated to 95°C, slowly add the weighed hypromellose...

Embodiment 2

[0045] In this example, a method for preparing hollow capsules for targeted release in the intestinal tract is proposed, which includes the following steps:

[0046] S1: Throwing tailings: according to the batch production instructions, after adding the measured purified water into the sol tank, turn on the stirring motor, then slowly add the weighed tailings into the sol tank, after stirring continuously, start to heat up;

[0047] S2: Heating up: Set the temperature controller at the desired temperature of 95°C, open the main steam valve, set the steam temperature to rise, open the steam electric control valve, steam enters through the upper interlayer pipe of the sol tank, flows out through the lower interlayer pipe, and then passes through After the output valve, it becomes condensed water and is discharged;

[0048] S3: Add raw materials and auxiliary materials and stir: when the temperature of the glue in the sol tank is heated to 95°C, slowly add the weighed hypromellos...

Embodiment 3

[0058] In this example, a method for preparing hollow capsules for targeted release in the intestinal tract is proposed, which includes the following steps:

[0059] S1: Throwing tailings: according to the batch production instructions, after adding the measured purified water into the sol tank, turn on the stirring motor, then slowly add the weighed tailings into the sol tank, after stirring continuously, start to heat up;

[0060] S2: Heating up: Set the temperature controller at the desired temperature of 95°C, open the main steam valve, set the steam temperature to rise, open the steam electric control valve, steam enters through the upper interlayer pipe of the sol tank, flows out through the lower interlayer pipe, and then passes through After the output valve, it becomes condensed water and is discharged;

[0061] S3: Add raw materials and auxiliary materials and stir: when the temperature of the glue in the sol tank is heated to 95°C, slowly add the weighed hypromellos...

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Abstract

The invention discloses a preparation method of an empty capsule for targeted release in intestinal tracts, which comprises the following steps: S1, adding tailings: adding metered purified water into a sol tank according to the requirement of a batch production instruction, starting a stirring motor, then slowly adding the weighed tailings into the sol tank, continuously stirring, and starting to heat; S2, rising temperature: setting a temperature controller at the required temperature of 95 DEG C, opening a steam main valve, setting steam temperature rise, opening a steam electric control valve, enabling steam to flow out through a lower interlayer pipeline after entering through an upper interlayer pipeline of the sol tank, and then changing the steam into condensed water to be discharged after passing through an output valve; and S3, adding the raw materials and the auxiliary materials, and stirring: when the temperature of the glue solution in the sol tank is heated to 95 DEG C, performing steps. The preparation method of the empty capsule designed and prepared by the invention is convenient in preparation process, can meet the requirements of people with various religious and vegetarian diet habits, and is relatively high in acceptability.

Description

technical field [0001] The invention relates to the technical field of hollow capsules, in particular to a preparation method for targeted release of hollow capsules in the intestinal tract. Background technique [0002] With the increase of capsule varieties, the diversity of its contents has gradually made people realize that there are compatibility problems between gelatin hollow capsules and some contents with special properties. For example, content containing aldehyde groups or reacting to form aldehyde groups under certain conditions may lead to cross-linking reaction of gelatin; content with strong reducibility may undergo Maillard reaction with gelatin; content with strong hygroscopicity It will cause the gelatin capsule shell to lose water and lose its original toughness. The above-mentioned stability problems of gelatin hollow capsules have drawn more attention to the development of new capsule materials. [0003] Therefore, with the development and industrializ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23P10/30A23L29/30A61K9/48A61K47/38
CPCA23P10/30A23L29/30A61K9/4816A61K9/4891A23V2002/00A23V2250/51086A23V2250/5036A23V2250/082A23V2250/086
Inventor 王有平
Owner 玖洲胶囊生物制药(广州)有限公司
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