Compound polysaccharide sodium hyaluronate gel and preparation method thereof

A technology of sodium hyaluronate and complex polysaccharides, which is applied in pharmaceutical formulations, prostheses, drug delivery, etc., and can solve problems such as insufficient smoothness of the surface of gel particles, adverse reactions, and poor viscoelasticity

Active Publication Date: 2021-05-18
QINGDAO CHENLAND MARINE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, the polymer material and hyaluronic acid are grafted to form a polymer, so that the cross-linked structure is more stable, but this preparation method is cumbersome and complicated, and it is difficult to remove the residual reagents in the gel, which will cause post-injection problems. some inflammations and infections
[0006] Therefore, in summary, the existing technology mainly has the following problems: Most of the sodium hyaluronate gels on the market are prepared using a single raw material. Due to the short degradation time, multiple injections are required to maintain the effect. To prolong the degradation time, excessive Cross-linking agent, too much cross-linking agent will cause a variety of adverse reactions in the body; the existing gel prepared by cross-linking reaction usually fixes a cross-linking temperature, has poor viscoelasticity and weak supporting force
The treatment method to prepare uniform particles is usually sieving and granulation. The surface of the gel particles prepared by this method is not smooth enough to easily cause clinical symptoms such as inflammation and infection.

Method used

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  • Compound polysaccharide sodium hyaluronate gel and preparation method thereof
  • Compound polysaccharide sodium hyaluronate gel and preparation method thereof
  • Compound polysaccharide sodium hyaluronate gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Prepare 30 mL of sodium hydroxide solution with a mass fraction of 1%, add 0.3 g of sodium alginate and stir evenly, then add 5.4 g of sodium hyaluronate powder into the mixed solution, and stir evenly until it becomes transparent. Add 500 μL of BDDE to the above solution, stir evenly for 30 minutes, take it out and let it stand in a water bath at 30°C for 5 hours. After thermal cross-linking is completed, transfer it to an environment at 4°C to continue cross-linking for 20 hours. After the cross-linking is completed, block gel is obtained. Divide the block gel into uniform small pieces, add 800mL of prepared PBS buffer to swell, change the buffer every two hours until the pH of the gel is around 7.0, the osmotic pressure is about 300mOsmol / L, and the gel weight It is 250g, which is the end point of swelling at this time. The swollen gel was homogenized into a composite gel with uniform particles and certain viscoelasticity using a homogenizer. The homogenization time ...

Embodiment 2

[0050] Prepare 30 mL of sodium hydroxide solution with a mass fraction of 1%, add 1.5 g of sodium alginate and stir evenly, then add 5.4 g of sodium hyaluronate powder into the mixed solution, and stir evenly until it becomes transparent. Add 500 μL of BDDE to the above solution, stir evenly for 30 minutes, take it out and let it stand in a water bath at 30°C for 5 hours. After thermal cross-linking is completed, transfer it to an environment at 4°C to continue cross-linking for 20 hours. After the cross-linking is completed, block gel is obtained. Divide the fast gel into uniform small pieces, add 800mL of prepared PBS buffer to swell, change the buffer every two hours until the pH of the gel is around 7.0, the osmotic pressure is about 300mOsmol / L, and the gel weight It is 250g, which is the end point of swelling at this time. The swollen gel was homogenized into a composite gel with uniform particles and certain viscoelasticity using a homogenizer. The homogenization time w...

Embodiment 3

[0052] Prepare 30 mL of sodium hydroxide solution with a mass fraction of 1%, add 1.5 g of sodium alginate and stir evenly, then add 5.4 g of sodium hyaluronate powder into the mixed solution, and stir evenly until it becomes transparent. Add 500 μL of BDDE to the above solution, stir evenly for 30 minutes, take it out and let it stand in a water bath at 30°C for 5 hours. After the thermal crosslinking is completed, transfer it to an environment at 4°C to continue crosslinking for 10 hours to obtain a block gel. Divide the block gel into uniform small pieces, add 800mL of prepared PBS buffer to swell, change the buffer every two hours until the pH of the gel is around 7.0, the osmotic pressure is about 300mOsmol / L, and the gel weight It is 250g, which is the end point of swelling at this time. The swollen gel was homogenized into a composite gel with uniform particles and certain viscoelasticity using a homogenizer. The homogenization time was 30 minutes, the speed of the homo...

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Abstract

The invention discloses a compound polysaccharide sodium hyaluronate gel and a preparation method thereof, and belongs to the technical field of high polymer material preparation. According to the method, sodium alginate polysaccharide and sodium hyaluronate are cross-linked at the same time in a multi-layer cross-linking mode to form composite gel, so that the composite gel with a stable structure is obtained, and the method specifically comprises the steps of dissolving, cross-linking, swelling, homogenizing and the like. The compound polysaccharide sodium hyaluronate gel has good biocompatibility, good elasticity, high supporting performance and strong enzymolysis resistance, and can better reduce adverse reactions such as infection, red swelling and the like.

Description

technical field [0001] The invention belongs to the technical field of polymer material preparation, and particularly relates to a composite polysaccharide sodium hyaluronate gel and a preparation method thereof. Background technique [0002] Natural hyaluronic acid has good moisturizing, lubricating, repairing and nutritional effects. Natural hyaluronic acid is easily decomposed in the body and has poor stability. Through advanced cross-linking technology, hyaluronic acid can have a more stable structure to obtain better mechanical strength and resistance to enzymatic hydrolysis. Cross-linked hyaluronic acid gel has now become the most widely used subcutaneous injection material in medical cosmetology, and a variety of products have been launched at home and abroad. These products are used for skin anti-wrinkle and filling and shaping. The excellent filling effect has been accepted by more and more beauty lovers. [0003] Sodium hyaluronate (HHA) gel for injection current...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08J3/075C08J7/02C08L5/08C08L5/04A61L27/20A61L27/50A61L27/52A61L27/58
CPCC08J3/246C08J3/075C08J7/02A61L27/20A61L27/50A61L27/52A61L27/58C08J2305/08C08J2405/04A61L2430/34A61L2400/06C08L5/08C08L5/04
Inventor 邹圣灿姜晓文王宝群林莎莎杨雪
Owner QINGDAO CHENLAND MARINE BIOTECH CO LTD
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