Application of 6-diazo-5-oxo-L-leucine in preparation of drugs for preventing and treating psoriasis
A technology of norleucine and psoriasis, applied in the field of medicine, can solve the problems such as the effect of psoriasis that has not been reported in the literature
Inactive Publication Date: 2021-05-18
深圳市福田区风湿病专科医院
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[0004] However, there is no literature reporting the role of DON in the prevention and treatment of psoriasis
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[0022] Example: Application of 6-diazo-5-oxo-L-norleucine in the preparation of drugs for preventing and treating psoriasis
[0023] Intervention method: 8-week-old Balb / c mice were selected, and IL-23 cytokines (1ug / mouse / day) were injected subcutaneously for 4 consecutive days to induce the psoriasis model. Dissolve DON in PBS, inject DON subcutaneously at the inflammatory site of induced psoriasis model with a 1ml syringe, the dose is DON (2mg / kg body weight / day), administer continuously for 4 days, and detect the therapeutic effect.
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The invention discloses application of 6-diazo-5-oxo-L-leucine in preparation of drugs for preventing and treating psoriasis, and relates to the technical field of medicine. Experimental comparisons discover that the skin thickening at the psoriasis lesion after DON metabolic intervention is obviously reduced, the infiltration of immune cells is reduced, and DON can effectively inhibit inflammatory local immune response; at the same time, DON alleviates the spleen swelling phenomenon of psoriasis, and also effectively inhibits the inflammatory immune response of psoriasis; and by detecting the expression of proinflammatory factors at the skin inflammation site of psoriasis, DON also inhibits the expression of such genes, and DON effectively alleviates the symptoms of psoriasis.
Description
technical field [0001] The invention relates to the technical field of medicine, more specifically, it relates to the application of 6-diazo-5-oxo-L-norleucine in the preparation of medicines for preventing and treating psoriasis. Background technique [0002] 6-diazo-5-oxo-L-norleucine (abbreviated as DON) is a glutamine antagonist, due to its similarity with glutamine, DON can enter its catalytic center and covalently bind Or alkylation to inhibit its activity, it can very broad-spectrum and effectively inhibit the activity of various enzymes that use glutamine as a substrate. At present, the compound is being studied for the treatment of diseases such as tumors. [0003] Psoriasis, also known as "psoriasis", is a common and recurring chronic inflammatory skin disease. The basic damage is red papules or plaques covered with silvery white scales. Scalp is more common. The course of the disease is persistent and intractable. The incidence of the disease is relatively hig...
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IPC IPC(8): A61K31/198A61P17/06A61P29/00
CPCA61K31/198A61P17/06A61P29/00
Inventor 叶志中沈南周海波尹志华
Owner 深圳市福田区风湿病专科医院
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