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Methods and apparatus for low-volatility sampling

A sample, analyte technology, used in the field of low volatility sampling and equipment, can solve the problem of expensive

Pending Publication Date: 2021-05-14
BRIGHTSPEC INC
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Problems solved by technology

Additionally, these research instruments use high-bandwidth digital components, and therefore, the research instruments are expensive

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  • Methods and apparatus for low-volatility sampling
  • Methods and apparatus for low-volatility sampling
  • Methods and apparatus for low-volatility sampling

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[0030] Molecular rotational resonance (MRR) spectroscopy can be used to monitor the completion of reactions, product yields, intermediates and impurities including isomers (enantiomers, diastereomers and / or regioisomers) . The impact of MMR spectroscopy comes from new chemical insights (eg, resolution and specificity), measurement yields, and the speed at which MMR spectroscopy can generate results. New chemical insights mean a greater ability to understand why chemical processes do or don't work as intended, and the speed to advance larger continuous manufacturing goals within the pharmaceutical industry.

[0031] Unlike other techniques used in analytical chemistry, MRR spectroscopy can be used to rapidly identify and quantify individual components in complex mixtures containing isomeric impurities that are often difficult or impossible to resolve by other techniques. The advantages of MRR spectroscopy make it particularly suitable for the analysis of volatile chemicals in ph...

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Abstract

Molecular rotational resonance (MRR) spectroscopy is a structurally-specific, high-resolution spectroscopy technique that can provide accurate reaction process data with finer time resolution than existing techniques. It is the only analytical technique that can make online chiral composition measurements. This makes it especially useful for online reaction monitoring, which is done today by manually pulling off samples and measuring samples offline and takes 3-4 hours per measurement. Conversely, an MRR spectrometer can resolve isomers in about 10 minutes when fed with a low-volatility sampling interface that connects directly to the reaction line. The sampling interface measures a precise sample of the reaction solution, boils off the solvent to concentrate the analyte, volatilizes the analyte, and injects the volatilized analyte into the MRR spectrometer's measurement chamber for an MRR measurement. The sample concentration and volatilization happen quickly and without any extra sample preparation. This makes reaction monitoring more feasible, thereby facilitating the manufacture of safer, cheaper and more effective medicaments.

Description

[0001] Cross References to Related Applications [0002] This application is required under 35 U.S.C. § 119(e) to U.S. Application No. 62 filed on August 8, 2018, entitled "Methods and Apparatus for Low-Volatility Sampling" / 715,846, which is incorporated herein by reference in its entirety. [0003] governmental support [0004] This invention was made with Government support under Grant No. W31P4Q-15-C-0019 awarded by the U.S. Army. The government has certain rights in this invention. Background technique [0005] Molecular rotational resonance (MRR) spectroscopy identifies molecules based on their fingerprints in the microwave to millimeter region of the spectrum (1-40 GHz in the microwave region and 30-3000 GHz in the millimeter region). Each compound's unique spectrum results from the interaction of radiation with the end-over-end rotation of each molecule in a low pressure (eg, less than 100 mTorr) gas phase environment. The pattern of the spectrum is very precise...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B5/055G01R33/485
CPCG01N24/008G01N22/00A61B5/055G01N24/085G01N24/087G01R33/46G01R33/485
Inventor J·L·尼尔M·马克尔R·雷诺兹
Owner BRIGHTSPEC INC
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