Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Adsorbent for removing protein-bound uremic toxin by hemoperfusion and preparation method thereof

A technology of hemoperfusion and adsorbent, which is applied in the direction of blood circulation treatment, chemical instruments and methods, suction devices, etc., to achieve good adsorption performance, environmental protection, cost reduction, and simple steps

Active Publication Date: 2022-05-10
NANKAI UNIV
View PDF14 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that although the above-mentioned products have achieved good clinical therapeutic effects, there is still room for improvement in the two aspects of continuing to improve the removal ability of PBUTs and removing middle molecular toxins at the same time.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Adsorbent for removing protein-bound uremic toxin by hemoperfusion and preparation method thereof
  • Adsorbent for removing protein-bound uremic toxin by hemoperfusion and preparation method thereof
  • Adsorbent for removing protein-bound uremic toxin by hemoperfusion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0077] According to another aspect of the present invention, the present invention also relates to a method for preparing an adsorbent for removing protein-bound uremic toxins by hemoperfusion as described above, comprising the following steps:

[0078] (a) mixing the oil phase and the water phase for polymerization, and obtaining resin A after separation;

[0079] The oil phase includes styrene, acrylonitrile, divinylbenzene, porogen and benzoyl peroxide;

[0080] The aqueous phase comprises gelatin, sodium chloride and water;

[0081] (b) adding concentrated sulfuric acid to the resin A obtained in step (a) for hydrolysis to obtain resin B;

[0082] (c) Mix the ethanol solution of the imprinted molecules, the resin B, 1,2-dichloroethane, and anhydrous ferric chloride to perform a cross-linking-imprinting reaction to obtain a protein-bound uremic drug for hemoperfusion removal. Adsorbents for toxins.

[0083] The preparation method of the invention has simple steps, mild c...

Embodiment 1

[0135] A method for preparing an adsorbent for removing protein-bound uremic toxins by hemoperfusion, comprising the following steps:

[0136] (a) Polymerization reaction: 15 mass parts of styrene, 15 mass parts of acrylonitrile, 70 mass parts of 80% divinylbenzene, 50 mass parts of toluene, 50 mass parts of n-octanol, 1.5 mass parts of Benzoyl oxide (BPO) is uniformly mixed and prepared into an oil phase, and dropped into a pre-prepared water phase containing 1% mass concentration of gelatin and 10% mass concentration of sodium chloride at 50°C, the mass of the water phase and the oil phase The ratio is 4:1; after mixing, let it stand for 10 minutes, start stirring, adjust the particle size to a suitable range, then raise the temperature to 90°C at a rate of 1°C / 2min, and keep it warm for 12h; stop the reaction, drain the polymerization mother liquor, and wash with water at 50°C Resin until the effluent is clear, ethanol extracts the porogen at room temperature and transfers to...

Embodiment 2

[0140] A method for preparing an adsorbent for removing protein-bound uremic toxins by hemoperfusion, comprising the following steps:

[0141] (a) Polymerization reaction: the styrene of 5 mass parts, the acrylonitrile of 5 mass parts, the 80% divinylbenzene of 90 mass parts, the toluene of 100 mass parts, the n-octanol of 50 mass parts, the BPO of 0.5 mass parts Mix them evenly to form an oil phase, and put them into a pre-prepared water phase containing 0.5% mass concentration of gelatin and 5% mass concentration of sodium chloride at 50°C, and the mass ratio of the water phase to the oil phase is 3:1; After mixing, let it stand for 10 minutes, start stirring, adjust the particle size to a suitable range, raise the temperature to 80°C at a rate of 1°C / 2min, and keep it warm for 10h; stop the reaction, drain the polymerization mother liquor, wash the resin with water at 50°C until the effluent is clear, Extract the porogen with ethanol at room temperature, transfer to the wat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
specific surface areaaaaaaaaaaa
water contentaaaaaaaaaa
Login to View More

Abstract

The invention relates to the technical fields of chemical engineering and biomedicine, in particular to an adsorbent used for hemoperfusion to remove protein-bound uremic toxins and a preparation method thereof. An adsorbent for removing protein-bound uremic toxins by hemoperfusion of the present invention is a porous resin with an amide group and polystyrene-acrylonitrile-divinylbenzene as a skeleton, and the porous resin has imprinted An imprinted cavity of a molecule; said imprinted molecule comprising a protein-binding toxoid and / or an analog of a protein-binding toxoid. The adsorbent of the present invention has a significant removal effect on protein-bound toxoids such as indoxyl sulfate and p-cresol sulfate, and has a significant effect on β 2 ‑Microglobulins, B vitamins 12 , creatinine, sodium pentobarbital and other medium and large molecules and small molecules also have certain scavenging ability, and have excellent safety performance and mechanical strength.

Description

technical field [0001] The invention relates to the technical fields of chemical engineering and biomedicine, in particular to an adsorbent used for hemoperfusion to remove protein-bound uremic toxins and a preparation method thereof. Background technique [0002] Uremia is a clinical syndrome shared by various advanced chronic kidney disease (CKD), which refers to a series of clinical manifestations that appear when chronic renal failure caused by CKD enters the terminal stage. sign. Uremic toxins refer to a large group of metabolic products that accumulate in the blood and tissues and are toxic as the renal function declines and the renal clearance rate of solutes decreases. The European Uremic Toxin Working Group (EUTox) divides them into three categories according to their biochemical characteristics and clearance methods: 1. Water-soluble, small molecular substances that are not bound to proteins, and the molecular weight is usually less than 500, such as urea, creatin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCB01J20/268B01J20/28004B01J20/28011B01J20/28064B01J20/3057B01J20/3085A61M1/3621
Inventor 欧来良于浩峰
Owner NANKAI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com