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Application of ellagic acid in preparation of medicine for relieving eye tissue lesions

A tissue lesion and ellagic acid technology, which is applied in the field of ellagic acid in the preparation of drugs for alleviating eye tissue lesions, can solve the problems of western medicine damage, cardiovascular and cerebrovascular diseases, and can not fundamentally solve diabetic eye diseases, etc., to reduce edema , reduce inflammation, and improve the effect of autophagic flow disturbance

Pending Publication Date: 2021-04-30
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine mainly uses some chemical components to dilate and dredge the stagnant blood vessels of patients with diabetic eye disease. Kidney and other organs are damaged, and western medicine will aggravate the damage, leading to cardiovascular and cerebrovascular diseases, renal failure and other adverse reactions
In the prior art, there are few natural substances specially used to improve diabetic eye tissue lesions with few adverse reactions. Whether ellagic acid can improve diabetic eye tissue lesions (including retinopathy) has not been reported

Method used

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  • Application of ellagic acid in preparation of medicine for relieving eye tissue lesions
  • Application of ellagic acid in preparation of medicine for relieving eye tissue lesions
  • Application of ellagic acid in preparation of medicine for relieving eye tissue lesions

Examples

Experimental program
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Effect test

Embodiment 1

[0046] This Example 1 provides the use of ellagic acid in the preparation of a drug for alleviating ocular tissue lesions.

[0047] The improvement effect of ellagic acid intervention on streptozotocin-induced diabetic retinopathy is as follows:

[0048] 1. Materials and Instruments

[0049] Blood glucose meter, test strips, electronic scale, electronic balance, ellagic acid, streptozotocin (STZ);

[0050] 2. The specific experimental operation process is as follows:

[0051] 1. Animal grouping and model establishment

[0052] 30 KM mice were prepared, and the feeding environment was controlled at a temperature of 22°C±1°C, a relative humidity of 30-40%, and a relatively stable clean environment with temperature and humidity maintained. Randomly select 10 as the normal control group (group C) and give common feed to feed;

[0053] The rest of the mice were randomly divided into diabetic eye disease group (M group) and diabetic eye disease + ellagic acid group (EA group). B...

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Abstract

The invention relates to the technical field of treatment of ocular tissue lesions, and particularly discloses application of ellagic acid in preparation of a medicine for relieving ocular tissue lesions, wherein the ellagic acid can regulate and control the rise of the expression level of LC3b / a protein and the reduction of the expression level of p62 protein in eyeball tissues of diabetic mice, improve autophagy disorder of diabetic ocular tissues, relieve diabetic mouse eye tissue pathological injury, inhibit eye tissue inflammation NLRP3 and IL-1beta protein expression, inhibit eye tissue apoptosis protein c-caspase1 expression, and inhibit mouse eye tissue pyroptosis protein GSDME, GSDME-N and GSDMD-N expression, so that GSDMD and GSDME mediated pyroptosis is inhibited, and an anti-inflammatory protection effect on cells is achieved. The ellagic acid provided by the invention can relieve pathological injury of eye tissues of diabetic mice and has a protective effect on retinas of the diabetic mice.

Description

technical field [0001] The invention relates to the technical field of treating eye tissue lesions, in particular to the use of ellagic acid in the preparation of medicines for alleviating eye tissue lesions. Background technique [0002] Diabetes is a common endocrine disease, the greatest harm is that it can cause many chronic complications, eye disease is one of the most common chronic complications of diabetes, known as diabetic eye disease. Among them, diabetic retinopathy (DR) is one of the serious microvascular and neurological complications. Glucolipid metabolism disorder causes diabetic ocular tissue cell damage, which can lead to abnormal ocular tissue structure and function. Autophagy can timely remove damaged proteins or organelles in cells, restore cell homeostasis, and reduce cell apoptosis in ocular tissues. Pyroptosis is a newly discovered mode of programmed cell death. After the activation of the inflammasome, it cuts caspase-1 / 4 / 5 / 11, and the mature caspa...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P27/02A61P3/10
CPCA61K31/366A61P27/02A61P3/10
Inventor 张䶮之张燕黄琦敏李倩祝颖玲加娜尔·依布拉阿洪王青古丽海夏古丽米拉
Owner XINJIANG MEDICAL UNIV
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