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Composition for prevention or treatment of prostate disease, containing extract from stauntonia hexaphylla and cornus officinalis as active ingredients

A technology of active ingredients and extracts, applied in the field of compositions for the prevention or treatment of prostate diseases, can solve problems such as multiple side effects and limited efficacy, and achieve excellent inhibitory effects

Inactive Publication Date: 2021-04-09
钟根堂健康株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs used in the treatment of benign prostatic hyperplasia in the past have shown many side effects and their efficacy is limited. Therefore, it is necessary to develop new therapeutic agents that have no side effects, do not cause drug resistance, and have excellent therapeutic effects

Method used

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  • Composition for prevention or treatment of prostate disease, containing extract from stauntonia hexaphylla and cornus officinalis as active ingredients
  • Composition for prevention or treatment of prostate disease, containing extract from stauntonia hexaphylla and cornus officinalis as active ingredients
  • Composition for prevention or treatment of prostate disease, containing extract from stauntonia hexaphylla and cornus officinalis as active ingredients

Examples

Experimental program
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preparation example Construction

[0037] In the preparation method of the present invention, the Japanese wild papaya or dogwood in step 1), whether cultivated or marketed, can be used without limitation. Furthermore, the above-mentioned papaya can use flowers, branches, stems, leaves, fruits, aerial parts, rhizomes, roots or combinations thereof, and more specifically, papaya leaves can be used.

[0038] In the preparation method of the present invention, preferably, water, alcohol or a mixture thereof can be used as the extraction solvent in the above step 1). Preferably, the above-mentioned alcohol uses C 1 to C 2 The lower alcohol, preferably ethanol or methanol is used as the lower alcohol. Preferably, the extraction method uses shaking extraction, Soxhelt extraction or reflux extraction, but is not limited thereto. Preferably, extraction is performed by adding 1 to 20 times the amount of extraction solvent relative to the dried Japanese wild papaya or dogwood, more preferably, 3 to 17 times the amount...

Embodiment 1

[0068] Embodiment 1. Preparation of Japanese wild papaya extract

[0069] 300 ml of 70% alcohol was put into 20 g of dried papaya leaves, and the low-temperature extraction was performed for 12 hours by ultrasonic waves. After the obtained extract was filtered with filter paper, 300 ml of 70% alcohol was used to extract the filtered residue at low temperature for 12 hours and the process of filtering was repeated twice. After the extraction, the filtrates were combined and concentrated under reduced pressure and freeze-dried to obtain the Japanese wild papaya extract.

Embodiment 2

[0070] Example 2. Preparation of Cornus officinalis Extract

[0071] 300 ml of 70% alcohol was put into 20 g of dried Cornus officinalis, and low-temperature extraction was performed for 12 hours by ultrasonic waves. After the obtained extract was filtered with filter paper, 300 ml of 70% alcohol was used to extract the filtered residue at low temperature for 12 hours and the process of filtering was repeated twice. After the extraction, the filtrates were combined and concentrated under reduced pressure and freeze-dried to obtain the Cornus officinalis extract.

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Abstract

The present invention relates to a composition for preventing or treating prostate disease containing, as active ingredients, extracts from Stauntonia hexaphylla and Cornus officinalis. In particular, the extracts from Stauntonia hexaphylla and Cornus officinalis are not cytotoxic and have an excellent effect in inhibiting the expression of androgen receptors, prostate specific antigens and prostate specific enzymes, and thus can be used as active ingredients of a composition for preventing or treating prostate disease.

Description

technical field [0001] The present invention relates to a composition for preventing or treating prostate diseases comprising Japanese wild papaya (Stauntonia hexaphylla) extract and cornus officinalis Sieb. et Zucc extract as active ingredients. Background technique [0002] The prostate is an accessory reproductive gland composed of glandular tissue and fibrous muscle tissue, which plays the role of producing and secreting semen. The prostatic fluid produced in the prostate provides nutrients to the sperm that are produced and moved in the testis, and helps the sperm motility by maintaining a liquid state so that the semen does not freeze after ejaculation. Representative prostate diseases include benign prostatic hyperplasia, prostate cancer and prostatitis. [0003] Prostatic hyperplasia (Benign prostatic hyperplasia, BPH) is one of the diseases common in adult males. According to reports, the attack rate of men over the age of 50 is 50%, and the attack rate of men over...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/40A61P13/08A23L33/105
CPCA61K36/185A61K36/40A23L33/105A61P13/08A23V2002/00A23V2200/30
Inventor 朴圣善赵卿媛郑周永金荣镐
Owner 钟根堂健康株式会社
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