Application of substance for detecting genetic marker to preparation of kit for risk early warning and early diagnosis of rectal cancer
A technology of genetic markers and risk early warning, which is applied to the detection of genetic markers in the field of preparation of risk early warning and early diagnosis of rectal cancer kits, which can solve problems such as delayed treatment and unobvious early symptoms of sCRC
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[0026] (1) Collection and preparation of clinical samples
[0027] According to clinical diagnosis and physical examination results, tumor tissues and normal tissues of 150 sCRC patients in the Chinese Han population were collected, of which 3 were frozen fresh tissues and their own blood samples for exome sequencing in the early stage, and the rest were paraffin-embedded samples for later stage Independent sample research, detailed records of sample clinical and pathological information. Inclusion criteria for the disease group: sCRC diagnosed by immunohistochemical detection (must include pathological diagnosis) for the first time, no obvious family medical history, and detection of mutation types of MLH1 and MSH2 genes that have diagnostic significance for the confirmed hereditary CRC of Chinese Han people Negative results; tumor tissue was stained by HE and confirmed that the proportion of tumor cells was greater than 80%; normal tissue refers to tissue with no tumor cells...
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