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Injection filling material and preparation process

A technology of filling materials and raw materials, applied in the field of biotechnology, can solve the problems of hidden safety hazards, single function of hyaluronic acid and collagen, and achieve the effects of good biological safety, prolonging the effective time, and long-lasting effect.

Inactive Publication Date: 2021-04-02
GUANGZHOU YICHENG BIOTECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At present, the materials used for the repair and reconstruction of human tissue functions include hyaluronic acid, collagen, and acellular matrix. Hyaluronic acid and collagen have a single function, and the acellular matrix can provide most of the nutrients and growth factors needed by the tissue. , but its production process introduces a variety of toxic substances, and the current production process is difficult to ensure that the impurities or fragments containing immunogenicity are removed under the premise of retaining functional components, so that it brings safety hazards

Method used

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  • Injection filling material and preparation process
  • Injection filling material and preparation process

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Effect test

Embodiment 1-3

[0028] The preparation method of embodiment 1-3 injection filling material is:

[0029] S1. Weigh the polyester microspheres in proportion, add them to a certain amount of dispersion liquid, stir mechanically for 30min, and stir at a rate of 500rpm;

[0030] S2. Add the recombinant protein into the dispersion, and stir it magnetically for 40 minutes until it is completely dissolved;

[0031] S2. Add silk fibroin to the dispersed liquid after stirring, and keep stirring for 40 minutes;

[0032] S3. Place the dispersion under a homogenizer, and emulsify it at 10,000 rpm for 10 minutes to form a suspension;

[0033] S4. While vortex stirring in the suspension, add sodium hyaluronate powder, and continue to stir until the suspension is gelatinous and no vortex is formed on the surface;

[0034] S5. Stand still for 72-96 hours until the hyaluronic acid swells evenly;

[0035] S6, put the swollen sodium hyaluronate into an emulsification tank, and vacuumize while stirring to elim...

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Abstract

The invention discloses an injection filling material and a preparation process. The filling material is prepared from the following raw materials in percentage by mass: 0.1-2% of sodium hyaluronate,1-30% of polyester microspheres, 0.1-5% of silk fibroin, 0.01-1% of recombinant III-type collagen and the balance of dispersion liquid. The polyester material is artificially synthesized, the sodium hyaluronate and the recombinant protein are prepared through a fermentation method, the silk fibroin is extracted from secretions of silkworms instead of animal tissues, and compared with collagen extracted from the animal tissues, the acellular matrix has better biological safety; the added polyester microspheres can form a slow release effect on the system, the effective time of the filling material is prolonged, and the lasting time of the filling material is longer than that of a single-component material; and the filling material comprises type I collagen (silk fibroin), type III collagen(recombinant protein) and carbohydrate nutrient substances (hyaluronic acid) required by tissue production, and a complete external environment can be provided for tissue production.

Description

technical field [0001] The invention relates to the technical field of biotechnology, in particular to an injection filling material and a preparation process. Background technique [0002] At present, the materials used for the repair and reconstruction of human tissue functions include hyaluronic acid, collagen, and acellular matrix. Hyaluronic acid and collagen have a single function, and the acellular matrix can provide most of the nutrients and growth factors needed by the tissue. , but its production process introduces a variety of toxic substances, and the current production process is difficult to ensure that the impurities or fragments containing immunogenicity are removed under the premise of retaining functional components, so as to bring safety hazards. [0003] The present invention provides a formula without adding harmful ingredients. The formula aims to provide a new type of implant with no rejection, excellent biocompatibility, similar physical and biologica...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/20A61L27/22A61L27/24A61L27/50
CPCA61L27/227A61L27/20A61L27/18A61L27/24A61L27/50A61L2400/06A61L2300/622A61L2300/602C08L5/08
Inventor 金振华区京华王立杰
Owner GUANGZHOU YICHENG BIOTECH CO LTD
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