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Anti-hepatic fibrosis traditional Chinese medicine compound composition and preparation method thereof

An anti-liver fibrosis and composition technology is applied in the field of anti-liver fibrosis traditional Chinese medicine compound composition and its preparation, which can solve the problems of large dosage, inaccurate curative effect, long taking period, etc. Marketing value, no side effects

Active Publication Date: 2022-03-01
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, related compound anti-hepatic fibrosis traditional Chinese medicine preparations have begun to appear in our country, but they are all large-scale compound crude preparations of traditional Chinese medicine, which have the disadvantages of large dosage, long taking cycle, inaccurate curative effect, difficult to study the treatment mechanism, etc., and are difficult to cope with the market anti-hepatic fibrosis. The needs of fibrosis patients, for this reason, a kind of anti-hepatic fibrosis Chinese medicine compound composition and its preparation method are proposed to solve the above problems

Method used

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  • Anti-hepatic fibrosis traditional Chinese medicine compound composition and preparation method thereof
  • Anti-hepatic fibrosis traditional Chinese medicine compound composition and preparation method thereof
  • Anti-hepatic fibrosis traditional Chinese medicine compound composition and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] Take 20g of Coptidis Rhizome, 15g of Paojiang, 13g of Sophora Sophora, 8g of Qingdai, 8g of Panax notoginseng, 5g of Woody Fragrance, 4g of Burnet Charcoal, and 5g of Licorice Root, grind them twice for 10 minutes, and add 30% ethanol-water solution , the mass ratio of crushed traditional Chinese medicine to ethanol-water solution is 1:5, slowly stirred at 70°C for 120min, condensed and refluxed at a constant temperature for extraction, extracted twice, combined extracts, filtered, and distilled to remove ethanol to obtain extracts, concentrated, added Excipients, tablet.

Embodiment 2

[0025] Take 25g of Coptis chinensis, 20g of Paojiang, 18g of Sophora flavescens, 16g of Qingdai, 12g of Panax notoginseng, 12g of woody incense, 8g of Burnet charcoal, and 10g of licorice, and grind it 4 times for 20 minutes, and add ethanol-water solution with a mass concentration of 30% , the mass ratio of crushed traditional Chinese medicine to ethanol-water solution is 1:5, slowly stirred at 85°C for 150min, condensed and refluxed at a constant temperature for extraction, extracted 3 times, combined extracts, filtered, distilled to remove ethanol to obtain extracts, concentrated, added Excipients, filling capsules.

Embodiment 3

[0027] Take 30g of Coptis chinensis, 25g of Paojiang, 24g of Sophora flavescens, 15g of Qingdai, 14g of Panax notoginseng, 15g of woody incense, 13g of Burnet charcoal, and 15g of licorice, and grind them three times for 15 minutes, then add 30% ethanol-water solution , the mass ratio of crushed traditional Chinese medicine to ethanol-water solution is 1:5, slowly stirred at 100°C for 180min, condensed and refluxed at a constant temperature for extraction, extracted 4 times, combined extracts, filtered, and distilled to remove ethanol to obtain extracts, concentrated, added Excipients, prepared into granules.

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Abstract

The invention discloses an anti-hepatic fibrosis traditional Chinese medicine compound composition, relates to the technical field of traditional Chinese medicine compound compositions, and comprises the following raw materials in parts by weight: 20-30 parts of Coptidis Rhizoma, 15-25 parts of Paojiang, and 13-24 parts of Sophora flavescens , 8-15 parts of Qingdai, 8-14 parts of Panax notoginseng, 5-15 parts of woody fragrance, 4-13 parts of Burnet charcoal, 5-15 parts of licorice, and its preparation method is also disclosed. The present invention can reduce liver fibrosis index , has a good prevention and treatment effect on liver fibrosis, is an extremely promising new traditional Chinese medicine, has no side effects, and has good market promotion value.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compound compositions, in particular to an anti-hepatic fibrosis traditional Chinese medicine compound composition and a preparation method thereof. Background technique [0002] Liver fibrosis is a pathophysiological process, which refers to the abnormal hyperplasia of connective tissue in the liver caused by various pathogenic factors. Any liver injury will have a process of liver fibrosis in the process of liver repair and healing. If the damage factors cannot be removed for a long time If the process of fibrosis persists for a long time, it will develop into liver cirrhosis. Therefore, it is not an independent disease. There are many causes of liver fibrosis. In clinical practice, viral hepatitis, alcoholic liver, fatty liver, and autoimmune diseases are more common. etc. According to reports, the incidence of hepatitis in China accounts for more than 10% of the total popu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P1/16A61K33/44
CPCA61K36/718A61K36/9068A61K36/489A61K36/704A61K36/315A61K36/195A61K36/258A61K36/285A61K36/739A61K33/44A61K36/484A61P1/16A61K2236/15A61K2236/333A61K2236/39A61K2300/00
Inventor 郑仕中陈利张峰邵江娟张自力夏思伟周媛媛
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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