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Application of plant extract in preparing medicine of naval 1.4 inhibitor

A technology of nav1.4 and plant extracts, applied in the direction of drug combination, plant raw materials, skin care preparations, etc., can solve the problem of high cost, achieve the effect of small molecular weight, low cost, and relax muscle tension

Pending Publication Date: 2021-03-26
瑞资兰(杭州)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main purpose of the present invention is to provide an almost non-toxic plant extract in the preparation of nav1.4 inhibitor drugs, to solve the high cost of nav1.4 inhibitors in the prior art and reduce nav1.4 inhibition The problem of the toxicity of the agent, in order to meet the needs of long-term application

Method used

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  • Application of plant extract in preparing medicine of naval 1.4 inhibitor
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  • Application of plant extract in preparing medicine of naval 1.4 inhibitor

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preparation example Construction

[0027] In order to facilitate the preparation of the plant extract of the present application, and the stable performance of the plant extract of the present application to inhibit nav1.4, some embodiments of the present application also provide a method for preparing the water extract of kumquat, including: Water is used to heat and reflux the kumquat peel to obtain a water extract; the water extract is subjected to solid-liquid separation and rotary evaporation to obtain a kumquat water extract, and the volume of the kumquat water extract is 1 / of the volume of the water extract 8~1 / 3, preferably the weight ratio of water and kumquat peel is 7~14:1, and the time of heating and refluxing extraction is preferably 1~5h. The kumquat water extract obtained by other extraction methods in the prior art also has the effect of inhibiting nav1.4 to a certain extent, but the above-mentioned preparation method is simple and easy to operate, and the obtained kumquat water extract is appli...

Embodiment 1

[0034] 1. Raw material preparation

[0035] Kumquat Alcoholic Extract: Use 500mL 20% ethanol solution to heat and reflux extract 50g of fresh Kumquat peel for 3 times, each time for 1h, combine the extracts for 3 times, and rotary evaporate after suction filtration to obtain about 50ml of alcohol extract .

[0036] Kumquat water extract: Use 500mL of water to heat and reflux extract 50g of fresh kumquat peel for 3 times, each time for 1h, combine the extracts from 3 times, filter and rotary evaporate to obtain about 50ml of water extract.

[0037] Polygonatum extract: Use 500mL of water to extract 20g of Cornus officinalis at 50-90°C for 50-90min to obtain Polygonatum extract;

[0038]Cornus officinalis extract: Use 500mL of water to extract 20g of cornus officinalis at 50-90°C for 50-90min to obtain the cornus officinalis extract.

[0039] The above-mentioned Polygonatum extract, Cornus officinalis extract and Kumquat water extract were mixed with a weight ratio of 5:5:1 to...

Embodiment 2

[0097] Preparation of anti-wrinkle cream

[0098] The total dose of the anti-wrinkle cream is 20g, and the proportion of the main component mixed extract is as follows: Polygonatum extract: Cornus officinalis extract: Kumquat extract=5:5:1, accounting for 5% of the total weight of the anti-wrinkle cream.

[0099] (1) Using Polygonatum extract, Cornus officinalis extract, and Kumquat water extract prepared in Example 1 as raw materials, prepare anti-wrinkle cream: take glyceryl monostearate 1-1.5g, stearic acid 2-3g, liquid Heat and melt 2.2g of paraffin, 0.7g of white vaseline, stir evenly, keep warm to 85°C-87°C as the oil phase, weigh 2.3g of glycerin, 50-70mg of triethanolamine, 7.2g of ultrapure water, and heat to dissolve 800.14g of Tween. Stir evenly to 85-87°C, slowly add the oil phase, stir evenly, add 1ml of extract and stir evenly until condensation.

[0100] (2) the Polygonatum extract prepared in Example 1, the cornus officinalis extract, the kumquat alcohol extra...

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Abstract

The invention provides an application of a plant extract in preparing a medicine of a naval 1.4 inhibitor. The plant extract comprises a polygonatum sibiricum extract, a cornus officinalis extract anda kumquat extract. The plant extract disclosed by the invention comprises the polygonatum sibiricum extract, the cornus officinalis extract and the kumquat extract, and the plant extract can block avoltage dependent Nav1.4 channel on a cell membrane in muscle, so that the release of ions is influenced, the action target is clear, and the effect is also clear. The compounds in the extracts are small in molecular weight and easy to penetrate through the skin, and the effect of remarkably relaxing excessively single muscular tension can be achieved.

Description

technical field [0001] The invention relates to the technical field of nav1.4 inhibition, in particular to the application of a plant extract in the preparation of nav1.4 inhibitor drugs. Background technique [0002] Sodium ions are composed of α subunits responsible for sensing voltage and ion selection and 1-2 β subunits that regulate it. In the human body, α subunits have 9 different subtypes, which are named Nav1.1 -1.9, β subunit has 4 subtypes, which are named β1-β4 respectively. [0003] The α subunit generally contains about 2000 amino acids, which includes four transmembrane domains I-IV with similar sequences and similar structures, and each domain contains 6 transmembrane helices. The first four transmembrane helices S1-S4 in each domain constitute the voltage sensor (VSD), and the four sets of S5-S6 transmembrane helices together constitute the pore domain responsible for ion permeability located in the center of the entire structure, connecting the transmembra...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P21/02A61K8/9794A61K8/9789A61Q19/08
CPCA61K36/40A61K36/75A61K36/8969A61K2236/331A61K2236/333A61Q19/08A61K8/9789A61K8/9794A61P21/02A61K2300/00
Inventor 潘兰英潘宏川
Owner 瑞资兰(杭州)生物科技有限公司
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