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A kind of melanoidin in Rehmannia glutinosa and its application

A technology of Rehmannia glutinosa and melanoidin, applied in the field of chemical medicine, can solve problems that need to be studied, and achieve the effect of promoting hematopoietic function and improving the number of nucleated cells in bone marrow

Active Publication Date: 2022-02-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the large polarity and molecular weight of melanoidin substances, it is easy to co-precipitate with polysaccharides and other substances in the process of water extraction and alcohol precipitation of rehmannia glutinosa. Therefore, a large amount of melanoidinoid substances may be mixed in the crude polysaccharide components. The material basis of the effect of yellow tonifying blood needs to be studied

Method used

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  • A kind of melanoidin in Rehmannia glutinosa and its application
  • A kind of melanoidin in Rehmannia glutinosa and its application
  • A kind of melanoidin in Rehmannia glutinosa and its application

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Experimental program
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Effect test

Embodiment 1

[0037] Extraction, separation and chemical characterization of melanoidins from Rehmannia glutinosa

[0038] 1. Experimental instruments and reagents

[0039] 1260infitiny high performance liquid chromatograph (Agilent Technologies Co., Ltd.); Alltech 3300ELSD detector (Grace Company, USA); DAD detector (Agilent Technologies Co., Ltd.); elemental analyzer (Germany elementar company); Tensor 27 Fourier transform infrared spectrometer ( Bruker, Germany); ultrapure water treatment system (Millipore, USA); ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); rotary evaporator (Gongyi Yingyu Hi-Tech Instrument Factory).

[0040] Fresh Rehmannia glutinosa is collected from Wuzhi County, Jiaozuo City, Henan Province. It is identified as the fresh tuber root of Rehmannia glutinosa Libosch. by Professor Yu Boyang of China Pharmaceutical University. "Nine Suns" to make rehmannia glutinosa, that is, add 30% rice wine to raw rehmannia glutinosa, mix well, put it in a steamer and...

Embodiment 2

[0060] Study on the Blood Enriching Effect of Rehmannia glutinosa melanoidin components

[0061] 1. Purpose of the experiment

[0062] To observe whether rehmannia melanoidin can promote bone marrow hematopoiesis.

[0063] 2. Experimental animals

[0064] Clean-grade male ICR mice, weighing 18-22 g, were purchased from the Medical Comparison Center of Yangzhou University, license number: SCXK (Su) 2017-0007. The animals were reared in an environment with a temperature of 24±1°C and a humidity of 65%, in an independent environment with alternating day and night, well-ventilated, and given free access to food and water. Adapt to the experimental environment before the start of the experiment, eliminate the interference of environmental factors on the experiment, and all operations and handling of experimental animals complied with the requirements of the Animal Ethics Committee of China Pharmaceutical University.

[0065] 3. Experimental drugs

[0066] "Nine Steams and Nine ...

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Abstract

The present invention relates to the preparation method and application of Rehmannia glutinosa melanoidin. The method uses Rehmannia glutinosa as raw material, extracts it by reflux with pure water, precipitates it with 80% ethanol, removes the supernatant, dissolves the precipitate, and absorbs it with D202 resin at 60°C for 6 h, eluted with dilute hydrochloric acid and dialyzed to obtain Rehmannia glutinosa melanoidin. Through pharmacodynamic experiments, the present invention finds that Rehmannia glutinosa melanoidin has the function of promoting the recovery of bone marrow hematopoietic function, and can be used for the treatment of diseases related to the loss of hematopoietic function, including chronic aplastic anemia, hemorrhagic anemia, and bone marrow suppression after chemotherapy. Wait.

Description

technical field [0001] The invention belongs to the field of chemical medicine and relates to the preparation and medical application of rehmannia glutinosa melanoidin. Background technique [0002] Rehmannia glutinosa is steamed and processed from the rhizome of Rehmannia glutinosa Libosch., a plant of the family Scrophulariae. Modern clinical research has also confirmed that Rehmannia glutinosa and its preparations can improve chronic aplastic anemia and other diseases related to hematopoietic dysfunction. Rehmannia glutinosa contains monosaccharides, oligosaccharides, polysaccharides, phenylethanol glycosides, furan aldehyde derivatives and other chemical components, among which crude polysaccharide components are considered to be the main material basis for the blood-enriching effect of rehmannia glutinosa. Due to the limitations of the separation method and efficiency of crude polysaccharide fractions, a large amount of non-polysaccharide substances may be mixed in the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P7/06
CPCA61K36/804A61P7/06A61K2236/331A61K2236/55A61K2236/51
Inventor 余伯阳戚进龚普阳
Owner CHINA PHARM UNIV
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