Application of flow chemistry in toluene nitrification

A technology of flow chemistry and nitration reaction, applied in the field of chemical materials, can solve the problems of difficult control of the reaction process, potential safety hazards, and overheating of the reaction, achieve high selectivity of the target product, reduce the possibility of accidents, and reduce the o/p value Effect

Pending Publication Date: 2021-03-16
成都睿和德医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the nitrification reaction is carried out in a conventional reactor, and the reaction process is not easy to control. If the heat of the reaction is concentrated and the heat is not transferred in time, the partial reaction of the reactor will be overheated, resulting in a huge safety hazard. High will also lead to the decomposition of nitric acid to produce a large amount of nitrogen dioxide gas, which will pollute the environment. For this reason, we propose an application of flow chemistry in toluene nitration

Method used

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  • Application of flow chemistry in toluene nitrification
  • Application of flow chemistry in toluene nitrification
  • Application of flow chemistry in toluene nitrification

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Embodiment 1

[0034] The invention provides a technical solution: an application of flow chemistry in toluene nitration.

[0035] In this embodiment, preferably, toluene is used as a solvent, nitric acid is used as a nitrating agent, and sulfuric acid is used as a catalyst to carry out the nitration reaction in a microchannel reactor.

[0036] In the present embodiment, preferably, the specific steps of the nitration reaction are as follows:

[0037] Step 1, mix the nitric acid of 1.0g, 15.2ml / mol and the sulfuric acid catalyst of 0.1g, obtain the mixed solution, then the mixed solution and the toluene of 10.0g, 21.7ml / mol are transported to 50ml micro Two inlets of the channel reactor;

[0038] Step 2, after the two liquids are mixed and contacted in the microchannel reactor and reacted, they flow out from the outlet of the microchannel reactor into the collection tank;

[0039] Step 3, the solution in the collection tank is left to stand for stratification, the upper layer is a mixture ...

Embodiment 2

[0060] The invention provides a technical solution: an application of flow chemistry in toluene nitration.

[0061]In this embodiment, preferably, toluene is used as a solvent, nitric acid is used as a nitrating agent, and sulfuric acid is used as a catalyst to carry out the nitration reaction in a microchannel reactor.

[0062] In the present embodiment, preferably, the specific steps of the nitration reaction are as follows:

[0063] Step 1, mix the nitric acid of 2.0g, 30.4ml / mol and the sulfuric acid catalyst of 0.1g, obtain mixed solution, then the toluene of mixed solution and 10.0g, 21.7ml / mol is transported to 50ml micro Two inlets of the channel reactor;

[0064] Step 2, after the two liquids are mixed and contacted in the microchannel reactor and reacted, they flow out from the outlet of the microchannel reactor into the collection tank;

[0065] Step 3, the solution in the collection tank is left to stand for stratification, the upper layer is a mixture of sulfuri...

Embodiment 3

[0086] The invention provides a technical solution: an application of flow chemistry in toluene nitration.

[0087] In this embodiment, preferably, toluene is used as a solvent, nitric acid is used as a nitrating agent, and sulfuric acid is used as a catalyst to carry out the nitration reaction in a microchannel reactor.

[0088] In the present embodiment, preferably, the specific steps of the nitration reaction are as follows:

[0089] Step 1, mix the nitric acid of 2.0g, 45.7ml / mol and the sulfuric acid catalyst of 0.1g, obtain the mixed solution, then the mixed solution and the toluene of 10.0g, 21.7ml / mol are transported to 50ml micro Two inlets of the channel reactor;

[0090] Step 2, after the two liquids are mixed and contacted in the microchannel reactor and reacted, they flow out from the outlet of the microchannel reactor into the collection tank;

[0091] Step 3, the solution in the collection tank is left to stand for stratification, the upper layer is a mixture ...

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Abstract

The invention discloses an application of flow chemistry in toluene nitrification. Toluene is used as a solvent, nitric acid is used as a nitrating agent, sulfuric acid is used as a catalyst, and a nitration reaction is carried out in a micro-channel reactor. The micro-channel reactor is applied to toluene nitration reaction, the advantages of high target product selectivity, high reaction speed and mild and easily-controlled reaction of the micro-channel reactor are utilized, and compared with a traditional method, the reaction temperature is lower than that of industrial toluene nitration reaction; meanwhile, the large specific surface area of the micro-channel reactor is utilized, heat exchange of a reaction system is fast, and the possibility of accidents caused by misoperation is reduced.

Description

technical field [0001] The invention belongs to the technical field of chemical materials, and in particular relates to the application of flow chemistry in toluene nitration. Background technique [0002] Mononitrotoluene has three isomers, ortho, meta, and para. Both p-nitrotoluene and o-nitrotoluene are important chemical materials, and both compounds are products of primary nitration of toluene. [0003] However, the nitrification reaction is carried out in a conventional reactor, and the reaction process is difficult to control. If the heat of reaction is concentrated and the heat is not transferred in time, the partial reaction of the reactor will be overheated, resulting in a huge safety hazard. At the same time, side reactions and over-reactions are prone to occur. High concentration will also lead to the decomposition of nitric acid to produce a large amount of nitrogen dioxide gas, which will pollute the environment. Therefore, we propose an application of flow che...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C201/08C01B17/74C01B21/40C01C1/02C01C1/242C07C205/06
CPCC07C201/08C01B21/40C01B17/74C01C1/242C01C1/02C07C205/06Y02P20/52
Inventor 黄薇张润民张怀
Owner 成都睿和德医药科技有限公司
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