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A ROS-sensitive nano-agent with synergistic induction of photodynamic therapy and ferroptosis and preparation method thereof

A photodynamic therapy and sensitivity technology, applied in the field of biomedicine to achieve good biocompatibility and biodegradability, enhance the effect of ferroptosis, and improve the efficiency of cancer treatment

Active Publication Date: 2022-07-19
JILIN INST OF CHEM TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, with the continuous development of medical technology, the drug resistance of some tumor cells has also emerged. A single treatment system can no longer meet the requirements of current cancer treatment. We need to combine multiple treatment methods to develop new nano-drug preparations

Method used

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  • A ROS-sensitive nano-agent with synergistic induction of photodynamic therapy and ferroptosis and preparation method thereof
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  • A ROS-sensitive nano-agent with synergistic induction of photodynamic therapy and ferroptosis and preparation method thereof

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Embodiment Construction

[0056] The invention will be described in detail below with reference to the accompanying drawings and specific embodiments. The embodiments are used to help understand the present invention and should not be regarded as limiting the protection scope of the present invention.

[0057] (1) Preparation of mPEG-b-P(ED-AA)LG-Ce6

[0058] (1) The synthesis process of mPEG-b-P(ED-AA)LG-Ce6 is shown in formula (I). First, 1 g of methoxy polyethylene glycol amine (mPEG-NH 2 , an average molecular weight of 5000) and 1.0532g of BLG-NCA were mixed and dissolved in 30mL of anhydrous dimethylformamide. The reaction solution was stirred under nitrogen protection at 30°C for 72 hours. After the reaction, the solution was poured into 300 mL of ether solution, and the polyamino acid main skeleton (mPEG-b-PBLG) was obtained by stirring, sedimentation, filtration and vacuum drying.

[0059] (2) 264 mg of dicyclohexylcarbodiimide (DCC) and 147 mg of N-hydroxysuccinimide (NHS) combined condensi...

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Abstract

A ROS-sensitive nano-agent with synergistic induction of photodynamic therapy and ferroptosis and a preparation method thereof belong to the technical field of biomedicine. The nano-reagent is constructed from a photosensitizer-modified ROS-sensitive amphiphilic block polymer, including an amphiphilic biodegradable polymer, a photosensitizer group attached to the tail end, and a side-chain-modified ferroptosis-inducing ROS. Sensitive sensitive monomer; amphiphilic polymer can self-assemble into a ROS-sensitive nanoagent with synergistic induction of photodynamic therapy and ferroptosis, in which the hydrophobic part self-assembles into a hydrophobic core and the hydrophilic part becomes hydrophilic shell. Finally, the self-assembly of the photosensitizer-modified ROS-sensitive amphiphilic block polymer is driven by the thin-film dispersion method into a ROS-sensitive nano-agent that can synergistically induce photodynamic therapy and ferroptosis. Synergistic effect of photodynamic and ferroptosis therapy on tumor growth inhibition.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a ROS (Reactive Oxygen Species, reactive oxygen species) sensitive nano-agent with synergistic induction of photodynamic therapy and ferroptosis and a preparation method thereof. Background technique [0002] Cancer is the old enemy of human health in our country and even in the world, and the incidence of cancer is also increasing day by day. The latest survey results show that in 2019, there were more than 20 million new cases of cancer worldwide, and more than 10 million deaths. Among them, the number of cancer incidence and deaths in China ranks first in the world. At present, the commonly used cancer treatment methods cannot provide satisfactory therapeutic effects, and have the defects of low specificity, strong toxic and side effects, and high recurrence rate. Early cancer is difficult to find, and tumor cells are easy to metastasize and spread through ly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/59A61K31/202A61K41/00A61P35/00B82Y5/00C08G69/10C08G69/48
CPCA61K47/59A61K41/0071A61K41/0076A61K31/202A61P35/00B82Y5/00C08G69/10C08G69/48A61K2300/00
Inventor 杨洪雨杜嘉萌付雁王楠楠刘长玲
Owner JILIN INST OF CHEM TECH
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