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Multi-dimensional bionic drug dissolution detection equipment and detection method

A detection equipment and multi-dimensional technology, applied in the direction of testing pharmaceutical preparations, material inspection products, etc., can solve the problems of reducing the bionic degree of the physiological environment of the gastrointestinal tract, unable to simulate, and unable to use bionic physiological dissolution fluids, etc.

Pending Publication Date: 2021-02-05
苏州安默医药科技有限公司
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Problems solved by technology

However, the existing technical means of dissolution experiments cannot simulate the effect of changes in physiological shear force brought about by intestinal peristalsis in the gastrointestinal tract on drug disintegration and release.
In addition, the existing bionic dynamic dissolution instruments will generate a large number of bubbles when simulating the pH value, so the bionic physiological dissolution solution cannot be used, thus reducing the bionic degree of the physiological environment of the gastrointestinal tract. In summary, the existing technical means cannot Simultaneously simulate the pH value change of the gastrointestinal tract environment, gastrointestinal fluid, gastrointestinal shear force and other dimensions, reducing the degree of bionic simulation

Method used

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  • Multi-dimensional bionic drug dissolution detection equipment and detection method
  • Multi-dimensional bionic drug dissolution detection equipment and detection method
  • Multi-dimensional bionic drug dissolution detection equipment and detection method

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Embodiment Construction

[0030] The following are specific embodiments of the present invention and in conjunction with the accompanying drawings, further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

[0031] Such as Figures 1 to 3 As shown, a multi-dimensional bionic drug dissolution testing equipment includes a base 1 and a water bath box 2. The water bath box can be made of transparent materials, and the water bath box 2 is equipped with a plurality of dissolution cups for containing the physiological fluid of the gastrointestinal tract. 3. A transparent material type can also be selected. A cover 41 is installed on the dissolution vessel 3. The lower end surface of the cover 41 is provided with a plurality of spikes 42 in a matrix. The spikes 42 extend downward into the dissolution vessel 3, and Do not abut against the bottom of the dissolution cup 3; the bracket is installed on the side of the base 1, and the lifting mec...

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Abstract

The invention discloses multi-dimensional bionic drug dissolution detection equipment and a detection method. The detection equipment comprises a base and a water bath box. A plurality of dissolutioncups used for containing a gastrointestinal tract physiological fluid are arranged in the water bath box, sealing covers are installed on the dissolution cups, and a plurality of conical thorns are arranged on the lower end faces of the sealing covers in a matrix shape; the conical thorns extend downwards into the dissolution cups and are positioned above a liquid level of the gastrointestinal tract physiological liquid; a support is installed on one side of the base, and a lifting mechanism is vertically arranged on the support; a stirring mechanism is arranged on the lifting mechanism in anup-down sliding manner and penetrates through the sealing covers to extend into the dissolution cups for stirring and shearing; and a ventilation mechanism is connected with the dissolution cups to adjust the pH value of the gastrointestinal tract physiological fluid. A bionic degree of a gastrointestinal tract physiological environment is improved through a synergistic effect of the gastrointestinal tract physiological environment, a pH value change and a stirring shear change.

Description

technical field [0001] The invention relates to the technical field of drug dissolution detection devices, in particular to a multi-dimensional bionic drug dissolution detection device and detection method. Background technique [0002] Gastrointestinal absorption of orally administered drugs is critical to the therapeutic efficacy of the drug. Among them, the disintegration and release of drugs in the gastrointestinal tract after oral administration is the first step and a key step in gastrointestinal absorption. The drug dissolution test in vitro is a simulated evaluation experiment for the gastrointestinal disintegration and release of drugs in vitro. However, the existing technical means of dissolution experiments cannot simulate the influence of changes in physiological shear force brought about by intestinal peristalsis in the gastrointestinal tract on drug disintegration and release. In addition, the existing bionic dynamic dissolution instruments will generate a la...

Claims

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Application Information

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IPC IPC(8): G01N33/15
CPCG01N33/15
Inventor 窦浏白方亮刘航
Owner 苏州安默医药科技有限公司
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