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Application of compound ZJU-37 in preparation of medicines for preventing and/or treating liver diseases

A technology of ZJU-37, liver disease, applied in the field of preparation of drugs for the prevention and/or treatment of liver disease, can solve problems such as unclear specific mechanism, and achieve the effect of obvious liver protection and treatment effects and obvious social benefits

Inactive Publication Date: 2021-01-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of RIP1 protein kinase inhibitors can reduce cell death and alleviate various inflammatory responses, but the specific mechanism is not clear

Method used

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  • Application of compound ZJU-37 in preparation of medicines for preventing and/or treating liver diseases
  • Application of compound ZJU-37 in preparation of medicines for preventing and/or treating liver diseases
  • Application of compound ZJU-37 in preparation of medicines for preventing and/or treating liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]Example 1 Preparation of compound ZJU-37 solution

[0027]Experimental method: Compound ZJU-37 was prepared as a storage solution of compound ZJU-37 after DMSO was used to help dissolve, and was diluted with PBS to prepare a solvent for compound ZJU-37 before injection.

Embodiment 2

[0028]Example 2 Study of Compound ZJU-37 and Nec-1s on LPS / GalN-induced acute liver failure, liver injury and systemic inflammation in mice

[0029]experimental method:

[0030]Animal models are research tools to verify whether new therapeutic drugs and new therapeutic methods are effective. The animal models currently used internationally to simulate liver failure include drug-induced liver failure models (para-acetaminophen model, LPS / GalN model, sulfur Acetamide model, carbon tetrachloride model, etc.), acute liver ischemia model, partial hepatectomy model, etc. Among them, the LPS / GalN model, because of its good reproducibility, insignificant extrahepatic toxicity, and liver injury performance close to clinical advantages, is an ideal liver failure animal model.

[0031]Six-week-old male C57BL / 6 mice (purchased from Nanjing Institute of Biological Medicine) were randomly divided into normal control group, model group (LPS / GalN group), compound ZJU-37 treatment group (5mg / kg ZJU-37+LPS / G...

Embodiment 3

[0035]Example 3 Study of compound ZJU-37 and Nec-1s on liver pathology and neutrophil infiltration in mice with acute liver failure induced by LPS / GalN

[0036]experimental method:

[0037]Six-week-old male C57BL / 6 mice (purchased from Nanjing Institute of Biological Medicine) were randomly divided into normal control group, model group (LPS / GalN group), compound ZJU-37 treatment group (5mg / kg ZJU-37+LPS / GalN group), compound Nec-1s treatment group (5mg / kg Nec-1s+LPS / GalN group). Compound ZJU-37 and Nec-1s were injected intraperitoneally, 30 minutes later, LPS / GalN (40μg / kg LPS+800mg / kg D-GalN) was injected intraperitoneally to build the model; the model group replaced the solvent of compound ZJU-37 with an equal volume of solvent ; The normal control group is not treated. Six hours after LPS / GalN modeling, liver samples were collected for HE and immunohistochemical staining.

[0038]Experimental results:

[0039]The experimental results are asfigure 2 Shown: Figures A and B represent the LPS / ...

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Abstract

The invention relates to the field of medicines, and particularly discloses an application of a compound ZJU37 shown as a formula I in preparation of medicines for preventing and / or treating liver diseases. Through extensive and deep studies, the invention discloses the application of the compound ZJU37 in preparation of medicines for treating liver diseases for the first time, and expands application fields of the compound ZJU37. Meanwhile, the invention provides new treatment methods and treatment medicines for severe hepatitis, liver failure and other major liver diseases. The compound ZJU37 of the invention has obvious liver protection and treatment effects, and has significant social benefits.

Description

Technical field[0001]The invention relates to the field of medicine, and specifically discloses the application of compound ZJU-37 in the preparation of drugs for the prevention and / or treatment of liver diseases.Background technique[0002]Acute and chronic liver injury is a common disease in clinical practice. If it is not controlled and treated in time, it will develop into irreversible diseases such as severe hepatitis and liver failure. The fatality rate of acute liver failure is as high as 80%~97. %. Currently, there is still a lack of clinically effective treatment methods and drugs for severe hepatitis and liver failure. Therefore, it is urgent to develop new therapeutic drugs and develop new treatment methods and methods to improve the survival rate of severe hepatitis. Studies have shown that the receptor-interacting protein kinase RIP1 is involved in various liver diseases. The use of RIP1 protein kinase inhibitors can reduce cell death and alleviate various inflammatory re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4178A61P1/16A61P29/00
CPCA61K31/4178A61P1/16A61P29/00
Inventor 陈智楼国华刘艳宁李爱春葛田田
Owner ZHEJIANG UNIV
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