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Magnolol and honokiol and method for preventing and treating fatty liver syndrome of laying hens by using magnolol and honokiol

A technology of honokiol and honokiol, applied in the field of livestock and poultry breeding, can solve the problems of many influencing factors, unclear mechanism of action, and large changes in the content of active active ingredients, and achieve stable effect, improve the degree of steatosis, Effects with a well-defined mechanism of action

Inactive Publication Date: 2021-01-15
INST OF ANIMAL SCI & VETERINARY HUBEI ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of Chinese herbal medicine has complex components, large changes in the content of active ingredients, many influencing factors, and unclear mechanism of action, etc., which need to be further resolved

Method used

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  • Magnolol and honokiol and method for preventing and treating fatty liver syndrome of laying hens by using magnolol and honokiol
  • Magnolol and honokiol and method for preventing and treating fatty liver syndrome of laying hens by using magnolol and honokiol
  • Magnolol and honokiol and method for preventing and treating fatty liver syndrome of laying hens by using magnolol and honokiol

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 900 45-week-old Jingfen No. 2 healthy laying hens were selected and randomly divided into 3 treatments with 10 repetitions for each treatment, which were control group, test 1 group and test 2 group. The control group was fed with basal rations (referring to American NRC (2012) laying hens nutritional requirements), and 100 mg / kg total phenols (magnolol: honokiol = 1:1) were added to the basal ration of test 1 group, and test 2 Add 200 mg / kg of total phenols to the basal diet of the group (Magnolol: Honokiol=1:1). Add 300 mg / kg of total phenols (Magnolol: Honokiol = 1:1) to the basal diet of the test group 3. The test period is 12 weeks, and it is carried out in the summer high temperature season (mid-June to the end of August). Feed consumption, daily egg production, total egg weight and dead eggs were recorded during the test period. At week 12 of the experiment, chickens were randomly selected for slaughter for each replicate. Record data such as layer weight and l...

Embodiment 2

[0031] Select 1800 45-week-old Jingfen No. 2 healthy laying hens, and randomly divide them into 6 treatments, each with 10 repetitions, which are respectively control group, test 1 group, test 2 group, test 3 group, test 4 group, test group 5 groups. The control group was fed with basal rations (refer to American NRC (2012) laying hens nutritional requirements), 300mg / kg honokiol was added to the basal ration of test group 1, and 300mg / kg honokiol was added to the basal ration of test group 2 300mg / kg of total phenols (magnonokiol: honokiol=2:1) ​​were added to the basal diet of the test group 3, and 300 mg / kg of total phenols (magnolol: honokiol = 2:1) were added to the basal diet of the 4 groups of experiments. Parkol = 1:2), and 300 mg / kg of total phenols were added to the basal diet of the test group 5 (Magnolol: Honokiol = 1:1). The feed preparation method adopts the premixing method provided in the present invention. The test period is 12 weeks, and it is carried out i...

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Abstract

The invention discloses magnolol and honokiol and a method for preventing and treating fatty liver syndrome of laying hens by using the magnolol and the honokiol. When the magnolol and the honokiol are applied to daily ration of laying hens, liver lipid accumulation can be effectively reduced, and the serum triglyceride level can be reduced. The expression of genes FASN and SCD1 related to fatty acid synthesis of the liver of the laying hen is remarkably reduced. The egg laying performance reduction of the cage-rearing laying hens caused by the fatty liver syndrome is relieved; the death and culling rate is reduced. And the magnolol and the honokiol have a synergistic effect in regulating liver lipid metabolism. The invention discloses an appropriate composition proportion of the magnololand the honokiol in preparation of feed additives or medicines for preventing and treating fatty liver syndrome of laying hens for the first time.

Description

technical field [0001] The invention relates to the application of magnolol and honokiol in the prevention and treatment of fatty liver syndrome of laying hens, and belongs to the technical field of livestock and poultry breeding. Background technique [0002] The liver is the main organ of chicken fat synthesis, and plays a key role in maintaining the body's lipid metabolism balance and ensuring normal production performance. During the breeding process of laying hens, various factors, such as genetics, feed, management, environment, etc., can easily cause abnormal lipid deposition in the liver and gradually lead to fatty degeneration and necrosis of liver cells, causing fatty liver syndrome (Fatty liver syndrome, FLS). The disease is one of the common nutritional and metabolic diseases in modern large-scale chicken farming. It can lead to a decrease in feed utilization and egg production performance. In severe cases, it can cause death and cause serious economic losses to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P1/16
CPCA61K31/05A61P1/16A61K2300/00
Inventor 陈芳魏金涛杜恩存赵娜樊启文金枫张巍黄静郭万正黄少文陶文静
Owner INST OF ANIMAL SCI & VETERINARY HUBEI ACADEMY OF AGRI SCI
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