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Lactobacillus reuteri and application thereof in reducing lipopolysaccharide concentration and improving insulin resistance

A technology of Lactobacillus reuteri and insulin resistance, applied in the field of microorganisms, can solve problems such as reducing people's quality of life, achieve the effect of improving insulin resistance and reducing the concentration of lipopolysaccharide

Inactive Publication Date: 2021-01-12
INNER MONGOLIA PUZE BIOLOGICAL PROD CO LTD
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0005] The current clinical treatment of diabetes drugs usually cause some side effects, seriously reducing people's quality of life

Method used

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  • Lactobacillus reuteri and application thereof in reducing lipopolysaccharide concentration and improving insulin resistance
  • Lactobacillus reuteri and application thereof in reducing lipopolysaccharide concentration and improving insulin resistance
  • Lactobacillus reuteri and application thereof in reducing lipopolysaccharide concentration and improving insulin resistance

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Embodiment Construction

[0032] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0033] The preparation method of the Lactobacillus reuteri PZLR.10 of the present invention comprises, domesticating the Lactobacillus reuteri PZLR.10 bacterial strain, obtaining working seeds for production, carrying out primary fermentation inoculation to the working seeds, and then carrying out secondary fermentation, two After the first-stage fermentation, the three-stage fermentation is carried out, and then the bacteria sludge is obtained by centrifugation, and the bacteria powder is obtained after the bacteria sludge is freeze-dried, and the bacteria powder is inspected and packaged for use.

[0034] The specific preparation method is that Lactobacillus reuteri PZLR.10 is anaerobically cultured in MRS medium at 37°C for 24 hours, centrifuged and washed with physiological saline for 3 times to obtain the wet cells of Lactobacillus reuteri PZLR.10, which ...

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Abstract

The invention discloses lactobacillus reuteri and application thereof in reducing lipopolysaccharide concentration and improving insulin resistance. The in-vitro blood glucose reducing capacity of lactobacillus reuteri PZLR.10 is evaluated, the improvement effect of the lactobacillus reuteri PZLR.10 on diabetic mice is evaluated through in-vivo experiments, the blood glucose reducing mechanism ofthe lactobacillus reuteri PZLR.10 is explored, and the fact that the lactobacillus reuteri PZLR.10 is an effective strain capable of reducing the lipopolysaccharide concentration and improving the insulin resistance is confirmed. The lactobacillus reuteri PZLR.10 is a potential good choice for treating diabetes through probiotics, belongs to lactobacillus, and can be conveniently subjected to genemodification to become a probiotic complex carrying more different functional characteristics, corresponding probiotic medicine is developed, the dominant function is achieved through the powerful growth characteristic and the probiotic characteristic of the probiotics, and therefore a new direction is opened for treating diabetes.

Description

technical field [0001] The invention belongs to the field of microbes, in particular the application of a strain of Lactobacillus reuteri in reducing the concentration of lipopolysaccharide and improving insulin resistance. Background technique [0002] In recent years, the number of people with diabetes has been increasing year by year. According to the forecast of the International Diabetes Federation, the number of people with diabetes worldwide will reach 629 million in 2045. Type 2 diabetes is a metabolic disease associated with chronic high blood sugar that can lead to complications such as dysfunction of the eyes, feet, kidneys, nerves, heart and blood vessels. In recent years, the rapid increase in the incidence and mortality of type 2 diabetes has become a serious global health problem. [0003] A large number of research results on the correlation between diabetes and intestinal flora at home and abroad show that in addition to factors such as genetics and eating...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/747A61P5/50A61P3/10A23L33/135A23L2/52C12R1/225
CPCC12N1/20A61K35/747A61P5/50A61P3/10A23L33/135A23L2/52A23V2002/00C12R2001/225C12N1/205A23V2400/173A23V2200/328
Inventor 闫继彪王潇潇邓翔
Owner INNER MONGOLIA PUZE BIOLOGICAL PROD CO LTD
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