Online detection device and rapid end point judgment method for vitamin C Yinqiao tablet granulation process based on near infrared spectrum technology

Abstract

The invention discloses an online detection device and a rapid end point judgment method for a vitamin C Yinqiao tablet granulation process based on a near infrared spectrum technology. The vitamin CYinqiao tablet granulation is carried out by adopting a high-shear granulation mode, a high-shear granulation shearing block specifically adopts powder briquetting, powder is specifically processed bya feeder, and the feeder comprises a motor. A rotating shaft is rotationally connected to the motor, a feeder is rotationally connected to the rotating shaft, a discharging port is formed in the end,close to the motor, of the feeder, the discharging port is fixedly connected with a lower shell, the motor, the rotating shaft and the feeder are arranged in the lower shell, an upper shell is detachably connected to the lower shell, a feeding port is fixedly connected to the upper shell, and a material distributing boss is detachably connected to the upper end of the rotating shaft. A first rotary table is fixedly connected to the material distribution boss and provided with a first feeding port. According to the online detection device, the rotary feeding is achieved, the feeding is more uniform, meanwhile, the NIR spectrum technology is applied to the online detection of vitamin C Yinqiao tablet granulation, and the product quality can be controlled.

Description

technical field [0001] The invention belongs to the technical field of medical detection, and more specifically relates to an online detection device and a rapid endpoint judgment method for the granulation process of vitamin C Yinqiao tablets based on near-infrared spectroscopy. Background technique [0002] High-speed shear granulation is a commonly used granulation method, which has the advantages of fast granulation speed, small particle size distribution, large particle bulk density, good fluidity, less fine powder, and particle hardness relative to fluidized bed granulation. It has become a common granulation method for granules, capsules, tablets and other common dosage forms. At present, the quality inspection method of high-shear granules mainly evaluates the granules after granulation. The detection method is cumbersome to operate, and most of the inspection methods use offline detection methods. The detection results are lagging behind and the cycle is long. It is...

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Problems solved by technology

[0005] The purpose of the present invention is to provide a technology based on near-infrared spectroscopy to solve the technical problems that the current production and granulation process control indicators of vitamin C Yinqiao tablets are single, there is no data-based online control, and the quality consistency of each batch of products cannot be guaranteed. The on-line detection device and rapid endpoint judgment method for the granulation process of Vitamin C Yinqiao Tablets, through the design of the feeder, the rotary feeding is realized to make the feeding more uniform. At the same time, NIR spectrum technology is applied to the granulation of Vitamin C Yinqiao Tablets, and the establishment A quantitative model for on-line detection of vitamin C Yinqiao tablets was established to control the product quality in the granulation of vitamin C Yinqiao tablets, which can effectively solve the problems of low process control and poor product uniformity in current products

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