Medical glass bottle with low liquid medicine residue and preparation method thereof

Abstract

The invention relates to a preparation method of a medical glass bottle with low liquid medicine residue. The preparation method comprises the steps of S1, coating the inner surface of the medical glass bottle with polystyrene microspheres; S2, enabling polysiloxane to permeate into gaps of the polystyrene microspheres, and forming a polysiloxane layer on the inner surface of the medical glass bottle; and S3, sintering the medical glass bottle at a certain temperature to volatilize the polystyrene microspheres, and curing the polysiloxane layer to obtain the medical glass bottle with low liquid medicine residue. Compared with a common single-layer polysiloxane layer, a nano polysiloxane structure formed by taking polystyrene microspheres as a template is more obvious in hydrophobic effect,and the contact angle of water drops can be more effectively increased, so that the wall-hanging phenomenon of liquid medicine is reduced, and liquid medicine residues are reduced; and the compact polysiloxane hydrophobic layer formed on the inner surface of the glass bottle can also play a role in isolating the liquid medicine from the glass, so that the migration of impurities and metal ions inthe glass to the liquid medicine is reduced, and the purity and stability of the liquid medicine are ensured.

Description

technical field [0001] The invention relates to the field of functional film materials, in particular to a medical glass bottle with low liquid residue and its preparation method and application. Background technique [0002] With the rapid development of the pharmaceutical industry, the quality requirements for pharmaceutical packaging materials are getting higher and higher. Correspondingly, the performance requirements for medical glass are also increasing. As a packaging material for expensive biochemical agents and vaccine products that are not easy to prepare, medical glass is of great significance. The medical glass currently on the market can generally achieve high mechanical strength, high thermal stability, strong water resistance, acid resistance, and alkali erosion resistance with the improvement of technology. However, due to factors such as design and production, there is a certain gap between the residual amount of drugs and the cleanliness of the internation...

AI Technical Summary

Problems solved by technology

However, due to factors such as design and production, there is a certain gap between the residual amount of drugs and the cleanliness of the international pharmaceutical industry. Drug adsorption will cause waste of drugs, increase product costs, and aggravate the corrosion of drug packaging materials, resulting in liquid Leakage will cause secondary pollution to the environment. Therefore, it is particularly important to improve the hydrophobicity of medical glass and reduce the residue of liquid medicine.

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