Use of methallyl trisulfide in the preparation of medicines for treating acute lung injury

A technology of methallyl trisulfide and acute lung injury, applied in the field of medicine, can solve the problem of no specific prevention and treatment drugs for ALI, and achieve the effect of improving pathological manifestations, reducing and reducing pulmonary edema

Active Publication Date: 2021-09-28
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still no effective prevention and treatment drug for ALI, and it is imminent to develop effective and safe ALI treatment drugs

Method used

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  • Use of methallyl trisulfide in the preparation of medicines for treating acute lung injury
  • Use of methallyl trisulfide in the preparation of medicines for treating acute lung injury
  • Use of methallyl trisulfide in the preparation of medicines for treating acute lung injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Chemical reagent and instrument

[0029] AMTS (CAS Number: 34135-85-8) Purchased from Hubei Xinkang Pharmaceutical Chemical Co., Ltd., LPS is purchased from Sigma, BCA kit purchase of self-competition Mo Fei Shier Technology Company, TNF-α, IL-1β kit purchase Since Wuhan Yunclong Technology Co., Ltd., corn oil is purchased by the market. Desktop frozen centrifuge Eppendorf (5804R), pipe gun (Eppendorf), Rward R540 enhanced small animal anesthesia machine.

[0030] Animal experiment

[0031] Take 60 ICR male mice, weight 18-22g, purchased from Jinan Pengyue Experimental Animal Breeding Co., Ltd., animal raised in IVC animal breeding, free drinking water. After a week of adaptive feeding, randomly divided into blank control group, model control group, AMTS low dose intervention group (25 mg / kg.bw), dose intervention group (50 mg / kg.bw), AMTS high dose intervention group (100 mg / kg.bw), 12 animals per group. The AMTS intervention group was allowed to give an equal amount...

Embodiment 2

[0053] A soft capsule containing acute lung damage containing methyl allyl trithio ether, which includes: methyl allyl trithio ether, excipient, soft adhesive case, and directly packaged by a soft capsule compression process. Dosage: Oral, 2.78 ~ 11.1mg / kg.bw, can be discreted according to the actual condition.

Embodiment 3

[0055] A dripping pill containing acute lung damage containing methyl allyl trithio ether, which includes: methylene trionyl ether, matrix, direct bracelet through dripping process. Dosage: Oral, 2.78 ~ 11.1mg / kg.bw, can be discreted according to the actual condition.

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Abstract

The invention discloses the use of methallyl trisulfide in the preparation of medicines for treating acute lung injury. And a methallyl trisulfide is used as an active ingredient of a drug for treating acute lung injury in preparations and compound preparations. The experimental results showed that compared with the blank control group, the ratio of lung wet weight to body weight in the model group increased, the pathological damage was obvious, and the protein content, cell number and pro-inflammatory factor levels in BALF increased, and the difference was statistically significant (P<0.05 ), indicating that the model is established.

Description

Technical field [0001] The present invention belongs to the field of medical technology. Specifically, a methyl allyl trithio ether is prepared in the preparation of the treatment of acute lung injury drugs. Background technique [0002] Acutelung Injury, Ali is related to a severe respiratory disease, which is related to the pneumatic inflammatory storm induced by pathogenic factors. Common pathogenic factors include bacterial virus infections, sepsis, misunderstanding. Ali can further cause acute respiratory distress syndrome or multi-organ dysfunction syndrome, and the mortality rate can reach more than 40%, which seriously endangers human health. At present, Ali still has no special effects to prevent drugs, develop effective, safe Ali treatment drugs is imminent. [0003] LPS is a glycoprotein in the surface of the Gram-negative cell wall, which can stimulate macrophages or the like to produce inflammatory responses, and currently use LPS to establish an acute lung injury mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/10A61K9/48A61K9/20A61K9/72A61P11/00
CPCA61K9/0073A61K9/20A61K9/48A61K31/10A61P11/00
Inventor 王硕陈芳董晶吴苹李震刘晋倩吕英杰马慧宇
Owner LIAOCHENG UNIV
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