Application of methyl allyl trisulfide in preparation of medicine for treating acute lung injury

A technology of methallyl trisulfide and acute lung injury, which is applied in the field of medicine and can solve the problems of no specific prevention and treatment drugs for ALI

Active Publication Date: 2021-01-08
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still no effective prevention and treatment drug for ALI, and it is imminent to develop effective and safe ALI treatment drugs

Method used

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  • Application of methyl allyl trisulfide in preparation of medicine for treating acute lung injury
  • Application of methyl allyl trisulfide in preparation of medicine for treating acute lung injury
  • Application of methyl allyl trisulfide in preparation of medicine for treating acute lung injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Chemical Reagents and Instruments

[0029] AMTS (CAS No.: 34135-85-8) was purchased from Hubei Xinkang Pharmaceutical Chemical Co., Ltd., LPS was purchased from Sigma, BCA kit was purchased from Thermo Fisher Scientific, TNF-α, IL-1β kits were purchased from Corn oil was purchased from the market from Wuhan Cloud Clone Technology Co., Ltd. Desktop refrigerated centrifuge Eppendorf (5804R), pipette gun (Eppendorf), Ruiwode R540 enhanced small animal anesthesia machine.

[0030] Animal experiment

[0031] 60 ICR male mice, weighing 18-22 g, were purchased from Jinan Pengyue Experimental Animal Breeding Co., Ltd., and the animals were raised in the IVC Animal Breeding Department, with free access to water and food. After one week of adaptive feeding, they were randomly divided into blank control group, model control group, AMTS low-dose intervention group (25mg / kg.bw), AMTS medium-dose intervention group (50mg / kg.bw), AMTS high-dose intervention group (100mg / kg.bw), 12...

Embodiment 2

[0053] The invention discloses a soft capsule containing methallyl trisulfide for treating acute lung injury. The soft capsule comprises: methallyl trisulfide, auxiliary materials and a soft capsule shell, and is directly packed by a soft capsule filling process. Usage and dosage: oral administration, 2.78~11.1mg / kg.bw, it can be determined according to the actual condition.

Embodiment 3

[0055] Disclosed is a drop pill containing methallyl trisulfide for treating acute lung injury. The drop pill comprises: methallyl trisulfide and a substrate, and is directly prepared into pills through a drop pill process. Usage and dosage: oral administration, 2.78~11.1mg / kg.bw, it can be determined according to the actual condition.

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Abstract

The invention discloses an application of methyl allyl trisulfide in preparation of a medicine for treating acute lung injury. The invention further discloses application of the methyl allyl trisulfide serving as a medicine active ingredient for treating acute lung injury in preparations and compound preparations. Experimental results show that compared with a blank control group, the lung-damp weight ratio of a model group is increased, pathological damage is obvious, the protein content, the cell number and the proinflammatory factor level in BALF are increased, the difference has statistical significance (P is smaller than 0.05), and it is indicated that the model is established.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the use of methallyl trisulfide in the preparation of medicines for treating acute lung injury. Background technique [0002] Acute lung injury (acutelung injury, ALI) is a serious clinical respiratory disease, which is mostly related to the pulmonary inflammatory storm induced by pathogenic factors. Common pathogenic factors are bacterial virus infection, sepsis, aspiration and so on. ALI can further cause acute respiratory distress syndrome or multiple organ dysfunction syndrome, and the fatality rate can reach more than 40%, seriously endangering human health. At present, there is still no specific drug for the prevention and treatment of ALI, and it is imminent to develop effective and safe drugs for the treatment of ALI. [0003] LPS is a glycoprotein on the surface of the cell wall of Gram-negative bacteria, which can stimulate macrophages to produce inflammat...

Claims

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Application Information

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IPC IPC(8): A61K31/10A61K9/48A61K9/20A61K9/72A61P11/00
CPCA61K9/0073A61K9/20A61K9/48A61K31/10A61P11/00
Inventor 王硕陈芳董晶吴苹李震刘晋倩吕英杰马慧宇
Owner LIAOCHENG UNIV
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