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Essence containing coenzyme Q10 lipidosome and preparation method of essence containing coenzyme Q10 lipidosome.

A technology of liposomes and essences, applied in medical preparations containing active ingredients, preparations for skin care, pharmaceutical formulas, etc., can solve problems such as poor water solubility of coenzyme Q10, inability to effectively exert effects, and low bioavailability. , to achieve the effect of protecting integrity, enhancing bioavailability and high safety

Inactive Publication Date: 2021-01-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, coenzyme Q10 has poor water solubility and is easy to decompose when exposed to light. The unstable characteristics limit its development.
At present, most of the preparations related to coenzyme Q10 are directly added, the bioavailability is low, and the effect cannot be effectively exerted

Method used

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  • Essence containing coenzyme Q10 lipidosome and preparation method of essence containing coenzyme Q10 lipidosome.
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  • Essence containing coenzyme Q10 lipidosome and preparation method of essence containing coenzyme Q10 lipidosome.

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] An essence containing coenzyme Q10 liposome, the composition and content are as follows:

[0032] Coenzyme Q10 liposome 1%, hydroxyethyl urea 4%, glycerin 10%, sodium hyaluronate 0.1%, xanthan gum 0.3%, carbomer 0.1%, triethanolamine 0.08%, aloe extract 5%, honeysuckle 5% extract, 0.3% phenoxyethanol, 0.3% methylparaben, and the balance is deionized water.

[0033] Among them, the coenzyme Q10 liposome contains coenzyme Q10, soybean lecithin and cholesterol, the weight ratio of soybean lecithin and cholesterol is 6:1, and the weight ratio of the total weight of soybean lecithin and cholesterol to coenzyme Q10 is 1:0.06. The preparation method of coenzyme Q10 liposome comprises the steps:

[0034] (1) Dissolve the phospholipids, cholesterol, and coenzyme Q10 in the prescribed amount respectively in chloroform, and oscillate evenly.

[0035] (2) After it is completely dissolved, put it into an eggplant-shaped bottle, and rotate it under reduced pressure on a 35°C water ...

Embodiment 2

[0045] An essence containing coenzyme Q10 liposome, the composition and content are as follows:

[0046] Coenzyme Q10 liposome 2%, hydroxyethyl urea 4%, glycerin 15%, sodium hyaluronate 0.5%, xanthan gum 0.5%, carbomer 0.2%, triethanolamine 0.15%, aloe extract 5%, honeysuckle 5% extract, 5% mugwort leaf extract, 0.3% phenoxyethanol, 0.2% methylparaben, and the balance is deionized water.

[0047]Among them, the coenzyme Q10 liposome contains coenzyme Q10, soybean lecithin and cholesterol, the weight ratio of soybean lecithin and cholesterol is 6:1, and the weight ratio of the total weight of soybean lecithin and cholesterol to coenzyme Q10 is 1:0.04. The preparation method of coenzyme Q10 liposome comprises the steps:

[0048] (1) Dissolve the phospholipids, cholesterol, and coenzyme Q10 in the prescribed amount respectively in chloroform, and oscillate evenly.

[0049] (2) After it is completely dissolved, put it into an eggplant-shaped bottle, and rotate it under reduced p...

Embodiment 3

[0059] An essence containing coenzyme Q10 liposome, the composition and content are as follows:

[0060] Coenzyme Q10 liposome 1.5%, hydroxyethyl urea 5%, glycerin 10%, sodium hyaluronate 1%, xanthan gum 0.5%, carbomer 0.1%, triethanolamine 0.05%, aloe extract 10%, benzene 0.3% oxyethanol, and the balance is water.

[0061] Among them, the coenzyme Q10 liposome contains coenzyme Q10, soybean lecithin and cholesterol, the weight ratio of soybean lecithin and cholesterol is 7.5:1, and the weight ratio of the total weight of soybean lecithin and cholesterol to coenzyme Q10 is 1:0.06. The preparation method of coenzyme Q10 liposome comprises the steps:

[0062] (1) Dissolve the phospholipids, cholesterol, and coenzyme Q10 in the prescribed amount respectively in chloroform, and oscillate evenly.

[0063] (2) After it is completely dissolved, put it into an eggplant-shaped bottle, and rotate it under reduced pressure on a water-bath rotary evaporator until the organic solvent is ...

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Abstract

The invention relates to the technical field of cosmetics, and particularly relates to essence containing coenzyme Q10 lipidosome and a preparation method of the essence containing the coenzyme Q10 lipidosome. The essence containing the coenzyme Q10 liposome is prepared from the following substances of 0.1%-10% of the coenzyme Q10 liposome, 2%-5% of hydroxyethyl urea, 5%-15% of glycerol, 0.01%-1%of sodium hyaluronate, 0.05%-2% of xanthan gum, 0.1%-0.3% of carbomer, 0.05%-0.3% of triethanolamine, 5%-20% of a traditional Chinese medicine plant extracting solution, 0.1%-1% of a preservative andthe balance of deionized water. The invention also provides the preparation method of the essence containing the coenzyme Q10 lipidosome. The essence contains the coenzyme Q10 which is wrapped by thelipidosome, the coenzyme Q10 is natural and mild, so that the stability of the product is improved, the irritation is reduced, the coenzyme Q10 is easy to absorb after being smeared on the skin, and can prevent photoaging, delay aging and nourish the skin.

Description

technical field [0001] The invention belongs to cosmetic technology, and in particular relates to an essence containing coenzyme Q10 liposome and a preparation method thereof. Background technique [0002] The aging of the human body is a natural law of growth, in which the skin is most affected and its changes are most obvious due to direct contact with the external environment. Generally speaking, when the age of 25 is used as the cut-off point for women, the skin will show a downward trend, and after the age of 30, aging symptoms will appear. Skin aging refers to the aging damage of skin function, which makes the skin's ability to protect the body and adjustment ability decline. As a result, the skin cannot adapt to changes in the internal and external environment, and the overall appearance of the skin changes in color, luster, shape, and texture. Therefore, for the majority of female consumers, anti-aging products are indispensable. [0003] Skin aging is mainly cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/35A61K8/55A61K8/63A61K8/14A61K8/9794A61K8/9789A61K8/73A61K8/42A61Q19/00A61Q19/08
CPCA61K8/355A61K8/553A61K8/63A61K8/14A61K8/9794A61K8/9789A61K8/735A61K8/42A61Q19/00A61Q19/08A61K2800/82A61K2800/56
Inventor 王伟张子琪王若彤李菁
Owner CHINA PHARM UNIV
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