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Tissue engineering material for inhibiting inflammation and promoting alveolar bone repair as well as preparation method and application thereof

A tissue engineering and inflammation-inhibiting technology, applied in tissue regeneration, prosthetics, medical science, etc., can solve the problems of unsatisfactory control of periodontal disease and the effect of alveolar bone repair, so as to promote the colonization and regeneration of own cells, The effect of periodontal disease control

Active Publication Date: 2020-12-25
天晴干细胞股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem that the existing materials for alveolar bone repair have unsatisfactory control effects on periodontal disease, thereby affecting the effect of alveolar bone repair, and provides a tissue engineering material that inhibits inflammation and promotes alveolar bone repair And its preparation method and application

Method used

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  • Tissue engineering material for inhibiting inflammation and promoting alveolar bone repair as well as preparation method and application thereof
  • Tissue engineering material for inhibiting inflammation and promoting alveolar bone repair as well as preparation method and application thereof
  • Tissue engineering material for inhibiting inflammation and promoting alveolar bone repair as well as preparation method and application thereof

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specific Embodiment approach 1

[0041] Specific Embodiment 1: The tissue engineering material for inhibiting inflammation and promoting alveolar bone repair in this embodiment includes sPL platelet factor preparation, poly-γ-glutamic acid and hyaluronic acid.

specific Embodiment approach 2

[0042] Embodiment 2: This embodiment differs from Embodiment 1 in that: the concentration of BMP in the sPL platelet factor preparation is 70-150 pg / mL. Others are the same as in the first embodiment.

[0043] Because bone morphogenic protein BMP is a bone growth factor that can induce bone formation and differentiation. sPL contains a large number of components that promote bone formation and differentiation, including PDGF, TGF-B, IGF-1 and BMP, while the content of BMP is relatively low, so the present invention prepares sPL by lysing after concentrating platelets and controlling the content of BMP form, to control the content of growth factors that promote bone formation in the overall sPL, thereby promoting bone formation. Studies have found that when the sPL preparation with a BMP content of less than 70pg / mL is combined with engineering materials, it takes a long time for the overall growth factors in the sPL in animals to act on the osteogenic ability, and the sPL prepa...

specific Embodiment approach 3

[0044] Embodiment 3: The difference between this embodiment and Embodiment 1 is that the molecular weight of the poly-γ-glutamic acid is 800,000-1.2 million Daltons. Others are the same as in the first embodiment.

[0045] The poly-γ-glutamic acid with this molecular weight has an excellent water retention effect, and is easy to wrap bovine bone microspheres and form a good hydration gel film, which is easy to make cells attach, migrate and grow.

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Abstract

The invention discloses a tissue engineering material for inhibiting inflammation and promoting alveolar bone repair as well as a preparation method and application thereof, and aims to solve the problem of influence of existing alveolar bone repair materials due to non-ideal periodontal disease control effect. The tissue engineering material for inhibiting inflammation and promoting alveolar bonerepair comprises an sPL platelet factor preparation, poly-gamma-glutamic acid and hyaluronic acid. The preparation method of the tissue engineering material for inhibiting inflammation and promotingalveolar bone repair comprises the following steps: 1, preparing the sPL platelet factor preparation; 2, adding poly-gamma-glutamic acid into the sPL platelet factor preparation, and carrying out uniform stirring; and then, adding hyaluronic acid, and carrying out uniform stirring so as to obtain a mixed solution, namely the tissue engineering material for inhibiting inflammation and promoting alveolar bone repair. The tissue engineering material for inhibiting inflammation and promoting alveolar bone repair disclosed by the invention is capable of controlling further absorption of the alveolar bone, as well as promoting autologous cell colonization so as to allow regeneration of the alveolar bone; and thus, alveolar bone regeneration can be effectively realized while controlling periodontal diseases. The tissue engineering material is used for repairing the alveolar bone.

Description

technical field [0001] The invention relates to a tissue engineering material for alveolar bone repair and its preparation method and application. Background technique [0002] Alveolar bone resorption is caused by periodontal disease, trauma or congenital malformation. As my country enters an aging society, periodontal disease has become a more prominent problem. The prevalence rate of periodontal disease in the world exceeds 10%, and the incidence rate of periodontal disease in China is estimated to be 50%. Periodontal disease starts from periodontitis. Due to the invasion of dental plaque, pathogenic bacteria in dental plaque can release a variety of inflammatory factors, causing immune stress response of periodontal tissue, resulting in gingival bleeding, periodontal Pocket formation and alveolar bone resorption, defective alveolar bone resulting in insufficient surrounding supporting tissue, eventually leading to tooth loss. The purpose of alveolar bone repair is to ...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/20A61L27/36A61L27/50A61L27/54A61L27/58
CPCA61L27/20A61L27/18A61L27/3608A61L27/54A61L27/50A61L27/58A61L2300/414A61L2430/12C08L5/08C08L77/04
Inventor 谢兴琴张怡刘艳青
Owner 天晴干细胞股份有限公司
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