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Application of pectolinarigenin in preparation of anti-esophageal cancer drug

A technology of willow rutin and esophageal cancer, applied in the field of cancer biomedicine, can solve the problems of poor prognosis and 5-year survival rate of patients with esophageal cancer

Inactive Publication Date: 2020-12-22
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although comprehensive treatment methods such as surgery, radiotherapy and chemotherapy have been continuously improved, the prognosis and 5-year survival rate of patients with esophageal cancer are still poor

Method used

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  • Application of pectolinarigenin in preparation of anti-esophageal cancer drug
  • Application of pectolinarigenin in preparation of anti-esophageal cancer drug
  • Application of pectolinarigenin in preparation of anti-esophageal cancer drug

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Embodiment Construction

[0021] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0022] application test

[0023] Materials and Methods

[0024] 1. Material

[0025] 1.1 Reagents

[0026] Liuchuanyu was purchased from Chengdu Puruifa Technology Development Co., Ltd., with a purity of 98%; 4% paraformaldehyde was purchased from Zhengzhou Paini Chemical Reagent Factory; pentobarbital sodium was purchased from Sinopharm Chemical Reagent Co., Ltd.; Physiological Saline was purchased from Chenxin Pharmaceutical Co., Ltd.; DMSO was purchased from sigma-aldrich Company of the United States; agar powder was purchased from Beijing Suolaibao Technology Co., Ltd.; Basal Medium Eagle was purchased from sigma-aldrich Company of the United States; L-glutamine was purchased from Beijing Sulaibao Technology Co., Ltd.; NaHCO3 was purchased from Tianjin Kaitong Chemi...

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Abstract

The invention discloses an application of pectolinarigenin in the preparation of an anti-esophageal cancer drug. Pectolinarigenin is named as 5,7-dihydroxy-4',6-dimethoxyflavone. The invention verifies the inhibition effect of pectolinarigenin on esophageal squamous cell carcinoma cells, and verifies the remarkable effect of pectolinarigenin on the prevention and treatment of esophageal cancer ona patient derived xenograft model (PDX). Research results show that pectolinarigenin can inhibit the proliferation of esophageal squamous cell carcinoma cells KYSE150 and KYSE450 and inhibit the cloneformation of the esophageal squamous cell carcinoma cells. Compared with a tumor volume of a control group, a tumor volume of a mouse treated by pectolinarigenin has a remarkable statistical difference. Therefore, the situation that pectolinarigenin has remarkable inhibition effects on esophageal squamous cell carcinoma cells and remarkable effects of preventing and treating esophageal cancer isshown. Therefore, pectolinarigenin can be used as an existing clinical use drug to play a role in preventing and treating esophageal squamous cell carcinoma.

Description

technical field [0001] The application belongs to the field of cancer biomedicine, and in particular relates to the application of ruthin in the preparation of anti-esophageal cancer drugs. Background technique [0002] Esophageal cancer (EC) is one of the major cancers that threaten human life. In some countries in Asia and some low-income countries such as South Africa, esophageal cancer has seriously affected people's lives. The main pathological types of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). In China, the incidence of esophageal squamous cell carcinoma accounts for more than 90% of the incidence of esophageal cancer, especially in some plain areas, such as Henan and Hebei. Due to the lack of effective early diagnosis, the diagnosis of esophageal cancer is often in the middle and late stage, resulting in poor prognosis. At present, surgery is still the main way to treat esophageal cancer, but the postoperat...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P35/00
CPCA61K31/352A61P35/00
Inventor 刘康栋董子钢朱芳丽郭智萍刘鑫宁赵继敏赵四敏江亚南董子明
Owner ZHENGZHOU UNIV
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