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Hyaluronic-acid-containing tooth whitening sticker and preparation method therefor

A technology of hyaluronic acid and tooth whitening, applied in dentistry, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of poor transdermal absorption rate, increase time, and affect efficacy, so as to ensure activity and efficacy, repair gum damage, Comfortable effect during use

Active Publication Date: 2020-12-22
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the peroxide composition may additionally contain triclosan, chlorhexidine, or vitamin E or its derivatives as a medicinal ingredient for treating oral diseases, or peroxide or chlorophyll or its derivatives for removing bad breath ; but considering that hyaluronic acid is only used as a component of humectants, it is mainly used to prevent the composition from drying during distribution, and cannot relieve the side effects of peroxides, and hyaluronic acid is in direct contact with peroxides, which is easy Degraded by peroxides to affect efficacy
[0008] Chinese patent CN 201720034971.7 discloses a cross-linked sodium hyaluronate gel patch, which includes a support layer, a cross-linked sodium hyaluronate layer and a release layer; the support layer has an inner cavity; the inner cavity It is composed of the arc-shaped gel outer layer and the gel inner layer of the support layer. The inner gel layer has a number of small holes, and the inner cavity is filled with a cross-linked sodium hyaluronate layer; the support The layer is placed on the release layer; the utility model has the advantages of being close to the eye skin and easy to penetrate; but considering that cross-linked sodium hyaluronate is a water-insoluble semi-solid gel, it can be combined with uncross-linked hyaluronic acid Compared with the poor transdermal absorption rate, this utility model uses cross-linked sodium hyaluronate to repair skin tissue, and the repair effect is limited
The preparation of the present invention with a high degree of tight binding increases the time of being tightly bound to the target site in the oral cavity, which is beneficial to achieve the desired effect; this patent mainly solves the problem of delivering drugs to the teeth and around the teeth, and does not consider the drug Stimulation to teeth and their surroundings

Method used

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  • Hyaluronic-acid-containing tooth whitening sticker and preparation method therefor
  • Hyaluronic-acid-containing tooth whitening sticker and preparation method therefor
  • Hyaluronic-acid-containing tooth whitening sticker and preparation method therefor

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Embodiment 1

[0035] Add sodium hyaluronate particles with a weight ratio of 0.1% into the cross-linked sodium hyaluronate gel, stir evenly, and prepare a gel for the gel layer A, and the cross-linked sodium hyaluronate gel is sodium hyaluronate and sodium hyaluronate gel. A water-insoluble semi-solid gel formed after the reaction of the cross-linking agent, the mass ratio of the cross-linking agent to the sodium hyaluronate is 0.2:100, the molecular weight of the sodium hyaluronate particles is 2200KDa, and the particle size is 10 microns .

[0036] The cross-linked sodium hyaluronate gel can adopt various cross-linking forms reported in the prior art that enable hyaluronic acid substances to form a three-dimensional network structure, such as chemical cross-linking. The chemical cross-linking refers to the cross-linking of hyaluronic acid under the action of chemical cross-linking agents, which can be selected from various available cross-linking agents, such as diglycidyl ether, divinyl ...

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Abstract

The application discloses a hyaluronic-acid-containing tooth whitening sticker and a preparation method therefor. The tooth whitening sticker comprises a film layer, a stripping lining layer and a gellayer located between the film layer and the stripping lining layer, wherein the gel layer comprises a gel layer A and a gel layer B, the gel layer A comprises crosslinked sodium hyaluronate gel andhyaluronic acid granules, a weight ratio of the hyaluronic acid granules to the crosslinked sodium hyaluronate gel is 0.1%-2%, and the gel layer B comprises 2%-20% of effective whitening ingredient, 15%-30% of gelling agent, 10%-50% of glycerine and 10%-80% of water. According to the tooth whitening sticker provided by the application, uncrosslinked hyaluronic acid can be prevented from being degraded by a strong oxidant, irritations to teeth and gums caused by the whitening ingredient can be alleviated, a use process is comfortable and is low in irritation, and after use, phenomena, i.e., aching, limp and sensitive teeth, swelling, painful and retracting gums and discolored mucosa do not occur.

Description

technical field [0001] The invention relates to the technical field of oral care products, in particular to a tooth whitening sticker containing hyaluronic acid and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, people pay more and more attention to tooth beauty, especially tooth whitening. There are a wide variety of teeth whitening products, including teeth whitening pens, teeth whitening kits, teeth whitening trays, teeth whitening stickers, etc. Because teeth whitening stickers are easy to carry, practical and simple, they are becoming more and more popular among consumers. [0003] The chemical components currently used for tooth whitening mainly include peroxides, such as hydrogen peroxide, carbamide peroxide, sodium perborate, sodium percarbonate; chlorite and hypochlorite, such as calcium chlorite, chlorous acid Barium, magnesium chlorite, aluminum chlorite, sodium chlorite, potassium chlorite, sodium h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/22A61K8/02A61Q11/00
CPCA61K8/735A61K8/22A61K8/0208A61Q11/00
Inventor 王静耿凤邵萌郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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