NGS-based brain tumor molecular diagnosis analysis method
A technology of molecular diagnosis and analysis method, which is applied in the analysis field of molecular diagnosis of brain tumors, can solve the problems of one-time detection of glioma, unsatisfactory detection, long time required, etc., and achieve short analysis cycle and good molecular analysis. Model, highly reproducible results
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[0054] Example: see Figure 1-2 , the present invention provides a technical solution: an analysis method for brain tumor molecular diagnosis based on NGS, the steps are as follows,
[0055] Step 1: Build a cluster based on the Amazon cloud platform; mainly including management nodes and computing nodes that meet the analysis requirements of brain tumor sample sequencing data volume, so as to facilitate rapid analysis of sample data;
[0056] Step 2: Build an analysis process for analyzing molecular markers of brain tumors on the cluster;
[0057] Step 3: The sequence comparison module is used to compare the sequencing read information to the human reference genome using biological comparison related software; the original sequencing data of the sample is de-adapted and low-quality reads are removed, and compared by bwa mem, picard AddOrReplaceReadGroups, indel region re-alignment and other steps to align high-quality reads to the human reference genome;
[0058] Step 4: The...
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