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Combined combination drug for resisting heart failure and application of combined combination drug in preparation of drug for resisting heart failure

A heart failure and drug technology, applied in the field of biomedicine, can solve the problems of large side effects and insufficient curative effect, and achieve the effect of reducing ROS content, increasing cell survival rate, and improving the effect of anti-heart failure

Active Publication Date: 2020-12-18
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is the technical problem that antihypertensive drugs in the prior art have insufficient curative effect and relatively large side effects in the treatment of heart failure

Method used

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  • Combined combination drug for resisting heart failure and application of combined combination drug in preparation of drug for resisting heart failure
  • Combined combination drug for resisting heart failure and application of combined combination drug in preparation of drug for resisting heart failure

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Embodiment Construction

[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with specific embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0022] The application of the combination drug for anti-heart failure according to the embodiment of the present invention and the combination of steroidal aldosterone receptor antagonist and β-cyclodextrin in the preparation of anti-heart failure drug will be described below in conjunction with specific examples.

[0023] The application according to the embodiment of the first aspect of the present invention is the application of steroidal aldosterone receptor antag...

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Abstract

The invention discloses a combined combination drug for resisting heart failure and application of a steroid aldosterone receptor antagonist and beta-cyclodextrin in preparation of a drug for resisting heart failure. The combined drug contains a diluent, an adhesive, a disintegrating agent, an antioxidant, an emulsifier, a solubilizer, the steroid aldosterone receptor antagonist and beta-cyclodextrin. According to the combined combination drug for resisting heart failure, compared with drugs such as spirolactone, beta-cyclodextrin, nebivolol and amlodipine which are independently used, the combined combination drug of the steroid aldosterone receptor antagonist and beta-cyclodextrin can significantly increase the cell survival rate, can reduce the ROS content in cells treated by adriamycin, can significantly improve the antioxidant ability of the cells, and can further greatly improve the anti-heart failure effect of the drug.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to an anti-heart failure combined drug and the application of the combination of steroidal aldosterone receptor antagonist and β-cyclodextrin in the preparation of anti-heart failure drugs. Background technique [0002] Heart failure (heart failure), referred to as heart failure, refers to the failure of the venous blood to fully discharge the heart due to cardiac systolic and / or diastolic dysfunction, resulting in blood stasis in the venous system and insufficient blood perfusion in the arterial system. Cardiac circulatory disorder syndrome, which is characterized by pulmonary congestion and vena cava congestion. The morbidity and mortality of heart failure among adults remains high worldwide, which may be due to the accelerated aging of the world-wide population and the increase in the number of acute cardiovascular events. [0003] At present, combined drugs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/724A61K31/585A61P9/04
CPCA61K45/06A61K31/724A61K31/585A61P9/04A61K2300/00
Inventor 段亚君王垣钰韩际宏梁英权杨潇潇赵虔陈元利
Owner HEFEI UNIV OF TECH
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