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Preparation method and application of ZIF-67 selenide

A technology of ZIF-67 and selenization, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, wave energy or particle radiation treatment materials, etc., can solve the problems of complex preparation methods, limited wide application, and expensive noble metal nanoparticles, etc. problems, to achieve the effects of simple preparation method, good photothermal effect, and high production and application value

Active Publication Date: 2020-11-24
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although gold-based photothermal agents have excellent photothermal effects, noble metal nanoparticles are expensive and complicated to prepare, which limits the wide application of this material.

Method used

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  • Preparation method and application of ZIF-67 selenide
  • Preparation method and application of ZIF-67 selenide

Examples

Experimental program
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Effect test

Embodiment 1

[0022] This embodiment provides a preparation method of selenized ZIF-67, specifically as follows:

[0023] Synthesis of S1, ZIF-67: (1) Weigh 0.275g Co(NO) 3 ·6H 2 O (1mmol) was ultrasonically dissolved in 10ml methanol to obtain A solution, 0.328g 2-methylimidazole (4mmol) was ultrasonically dissolved in 5ml methanol to obtain B solution, and then B solution was slowly added dropwise to A solution;

[0024] (2) Let it stand for 12-24 hours, and wash 2-4 times with 10000-16000r centrifuge, 5-10min each time, until the upper layer solution is clear, pour off the supernatant, and you can get blue nanoparticles, that is, zeolite imidazolyl Metal-organic framework ZIF-67, ZIF-67 is dispersed in methanol to obtain a methanol solution of ZIF-67.

[0025] S2. Preparation of Selenized ZIF-67: Weigh 0.045g of selenium powder (1mmol), dissolve it in 4mL of hydrazine hydrate, and after it is completely dissolved, add the solution to a reactor containing 40mL of methanol, and then add ...

Embodiment 2

[0029] The difference between the present embodiment and Example 1 is: in step S2, the selenium powder dissolved in hydrazine hydrate is added in the reactor that 20mL DMF (dimethylformamide) is housed, and the addition of ZIF-67 It is 0.1 mol, hydrothermal reaction at 150-250 ℃ for 48-72 hours to obtain selenide ZIF-67.

Embodiment 3

[0031] The difference between this embodiment and Example 1 is: in step S2, the selenium powder that is dissolved in hydrazine hydrate is added in the reactor that 10mL DMSO (dimethyl sulfoxide) is housed, and the addition of ZIF-67 It is 0.2 mol, hydrothermal reaction at 150-250 ℃ for 48-72 hours to obtain selenide ZIF-67.

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Abstract

The invention discloses a preparation method of ZIF-67 selenide. The preparation method comprises the following steps: S1, synthesis of ZIF-67: respectively dissolving 2-methylimidazole and Co(NO)3.6H2O in methanol, dropwise adding a 2-methylimidazole methanol solution into a Co(NO)3.6H2O methanol solution, performing standing, and then performing centrifugal washing to obtain blue nanoparticles,namely the ZIF-67; and S2, preparation of the ZIF-67 selenide: adding a selenium powder dissolved in hydrazine hydrate into an organic solvent, adding the ZIF-67 prepared in the S1, performing uniformmixing, then performing hydrothermal reaction, performing cooling, and then performing centrifugal washing so as to obtain the ZIF-67 selenide. The novel photothermal therapeutic agent selenide ZIF-67 provided by the method is simple in preparation method, low in cost of raw materials, good in photothermal effect and capable of rapidly heating under laser irradiation, so that the effect of killing tumors in vivo is achieved, and the photothermal therapeutic agent selenide ZIF-67 is suitable for large-scale popularization and application and has relatively high production and application values.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to a preparation method and application of selenized ZIF-67. Background technique [0002] In today's society, the morbidity and mortality of tumors are increasing year by year. At present, tumor treatment methods mainly include surgical resection, chemotherapy and radiotherapy, among which surgical resection will cause great trauma to the human body, and cannot be used for advanced malignant tumors with multiple distant metastases; while chemotherapy and Radiation therapy lacks specificity and can also cause damage to normal tissues and cells. Therefore, the improvement of tumor treatment methods is imminent. Photothermal therapy (Photothermal therapy, PTT) is a minimally invasive tumor treatment technology that has developed rapidly in recent years. It mainly uses materials with high photothermal conversion efficiency, injects them into the human body, and uses...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K41/00A61P35/00
CPCC08G83/008A61K41/0052A61P35/00
Inventor 徐祖顺潘馨园乔晨旭甄琳吴佳芮
Owner HUBEI UNIV
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