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Production process for anti-bonding soft capsule and anti-bonding combined solution for same

A production process and anti-sticking technology, which is applied in the direction of capsule delivery, non-active ingredients of polymer compounds, medical preparations of non-active ingredients, etc., can solve the problems of easy sticking of soft capsules, achieve good protection effect, and solve The effect of bonding into agglomerates and high temperature resistance

Active Publication Date: 2020-11-20
浙江新维士生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the sticking problem of soft capsules in the existing production technology, the present invention provides a soft capsule anti-sticking combination liquid and its production process, which can effectively solve the production technical problem that soft capsules are prone to sticking

Method used

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  • Production process for anti-bonding soft capsule and anti-bonding combined solution for same
  • Production process for anti-bonding soft capsule and anti-bonding combined solution for same
  • Production process for anti-bonding soft capsule and anti-bonding combined solution for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The embodiment of the present invention provides the specific implementation of soft capsule anti-bonding production technology, and the steps are as follows:

[0054] 1. Prepare 1020g of anti-adhesive combination liquid, which includes 1000g of soft capsule rubber lubricating oil and 20g of anti-adhesive combination wax;

[0055] 2. Put the transparent paraffin oil balls directly into the anti-adhesive combination solution, stir for 10 seconds, take them out, and dry the balls with an oil-absorbing cloth.

[0056] 3. The paraffin oil balls obtained in Example 1 were carried out to the soft capsule binding test, and the results are shown in Table 1.

Embodiment 2

[0058] The embodiment of the present invention provides the specific implementation of soft capsule anti-bonding production technology, and the steps are as follows:

[0059] 1. Prepare 1030g of anti-adhesive combination liquid, which includes 1000g of soft capsule rubber lubricating oil and 30g of anti-adhesive combination wax;

[0060] 2. Put the transparent paraffin oil balls directly into the anti-adhesive combination solution, stir for 10 seconds, take them out, and dry the balls with an oil-absorbing cloth.

[0061] 3. The paraffin oil balls obtained in Example 2 were subjected to a soft capsule binding test, and the results are shown in Table 1.

Embodiment 3

[0063] The embodiment of the present invention provides the specific implementation of soft capsule anti-bonding production technology, and the steps are as follows:

[0064] 1. Prepare 1035g of anti-adhesive combination liquid, which includes 1000g of soft capsule rubber lubricating oil and 35g of anti-adhesive combination wax;

[0065] 2. Put the transparent paraffin oil balls directly into the anti-adhesive combination solution, stir for 10 seconds, take them out, and dry the balls with an oil-absorbing cloth.

[0066] 3. The paraffin oil balls obtained in Example 3 were subjected to a soft capsule binding test, and the results are shown in Table 1.

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Abstract

The invention provides a production process for an anti-bonding soft capsule. The anti-bonding soft capsule comprises a gelatin solution used for making a capsule and an anti-bonding combined solutionused for performing anti-bonding treatment on the capsule, wherein the gelatin solution comprises the following components in terms of the weight ratio of gelatin: 100% of the gelatin, 40-50% of glycerin, 5-15% of a sorbitol solution and 95-100% of purified water. The process comprises the following steps: step 1, melting of the gelatin: a step of dissolving the gelatin, the glycerin, the sorbitol solution, the purified water and the like according to a certain ratio so as to prepare the gelatin solution used for pelleting; step 2, batching: a step of preparing contents according to a formulaproportion, paying attention to the fineness, solid content, viscosity and fluidity of materials when the materials are prepared for a suspension soft capsule, and carrying out grinding through a bead mill if necessary; step 3, pelleting and shaping: a step of pressing soft capsules through a soft capsule pelleting machine, and performing primary shaping and drying in a shaping rotary cage; step4, drying and spraying of the anti-bonding combined solution: a step of wrapping the outer surface of the rubber of the soft capsule with the anti-bonding combined solution; and step 5, pellet picking. The production process provided by the invention can effectively solve the production technical problem that the soft capsules are easy to bond.

Description

technical field [0001] The invention relates to the technical field of soft capsule production technology, in particular to an anti-adhesion soft capsule production technology and an anti-adhesion combination liquid. Background technique [0002] Soft capsule refers to sealing a certain amount of material liquid in a soft capsule material. The soft capsule material, namely the rubber, is made of gelatin, glycerin and purified water; The moisture accumulated on the surface is sticky, which makes the soft capsules stick to each other; when the produced product is kept in an environment above 30°C for a period of time, it will stick to a block and is not easy to shake. With the extension of storage time, The degree of bonding is more serious, forming clumps that cannot be broken up, resulting in deformation and rupture of the balls, so that the product cannot be eaten normally. [0003] Therefore, it is necessary to develop a soft capsule anti-bonding production technology to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/06A61K47/14A61K47/24A61K47/44A61J3/07
CPCA61J3/078A61K9/4816A61K9/4825A61K9/4833A61K47/06A61K47/14A61K47/24A61K47/44
Inventor 凌海源蔡振保宋吕春李新平杨金山
Owner 浙江新维士生物科技有限公司
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