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Diagnostic marker for predicting intestinal cancer liver metastasis and application

A technology for diagnosing markers and liver metastases, applied in the field of molecular biomedicine, can solve problems such as unpredictable liver metastases, and achieve the effect of high detection specificity, sensitivity and high throughput

Pending Publication Date: 2020-11-10
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI +1
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Problems solved by technology

Laboratory examinations include stool routine, fecal occult blood test, imaging examination, B-ultrasound, CT scan, colonoscopy, etc.; commonly used markers are carcinoembryonic antigen (CEA), colorectal cancer antigen (CCA), and CA19-9, but These antigen tests are generally only able to determine whether there is cancer, or whether the cancer has recurred, and cannot predict whether liver metastasis will occur

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  • Diagnostic marker for predicting intestinal cancer liver metastasis and application
  • Diagnostic marker for predicting intestinal cancer liver metastasis and application
  • Diagnostic marker for predicting intestinal cancer liver metastasis and application

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Embodiment Construction

[0049] For the first time, the present invention provides a diagnostic model for the relationship between methylation and liver metastasis of intestinal cancer based on high-throughput sequencing of surgical tissue samples of the primary tumor of early intestinal cancer. This model can diagnose the possibility of developing liver metastasis in early intestinal cancer and improve The specificity and sensitivity of colorectal cancer liver metastasis prediction.

[0050] Experimental method step of the present invention is as figure 1 shown.

[0051] The situation of the population samples involved in the present invention

[0052] From 2012.7 to 2018.12, 59 cases of colorectal cancer patients with primary tumor tissue and samples of paracancerous and metastatic tumors were collected, and the patients had 5 years or more of follow-up monitoring to determine whether they had cancer in the late stage after surgical resection of the primary colorectal cancer Liver metastases oc...

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Abstract

The invention relates to a methylation marker for intestinal cancer liver metastasis and application, and belongs to the technical field of molecular biomedicine. According to the method, intestinal cancer liver metastasis is researched through methylation of intestinal cancer for the first time, methylation difference related to liver metastasis of intestinal cancer is found to appear at the early stage of intestinal cancer for the first time, methylation difference sites of liver metastasis and non-liver metastasis of intestinal cancer are screened out, and five optimal difference methylation regions are used for screening methylation difference sites of liver metastasis and non-liver metastasis of intestinal cancer through a random forest method. And DMR) an intestinal cancer methylatedliver metastasis risk prediction model is established, which is suitable for predicting the risk assessment of liver metastasis of early intestinal cancer in the future.

Description

technical field [0001] The invention relates to a methylation marker of intestinal cancer liver metastasis and its use, belonging to the technical field of molecular biomedicine. Background technique [0002] Globally, the incidence of colon cancer ranks third among malignant tumors, with approximately 1.2 million new cases each year. According to the latest statistics in 2015, the mortality rate of bowel cancer in my country ranks fifth among malignant tumors, with a total mortality rate of 191 / 100,000, including 111 / 100,000 males and 80 / 100,000 females. Studies have shown that more than 50% of colorectal cancer patients have distant metastases when they are diagnosed, and the distant metastases are mainly in the liver. The metastases of colon cancer mainly include hematogenous metastasis, peritoneal metastasis, and lymph node metastasis. The most common organ of metastasis is the liver. Because the mesenteric blood vessels drain to the portal vein in anatomical structure,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B30/10G16H50/20G06Q10/04G06K9/62C12Q1/6886C12Q1/6869
CPCG16B30/10G16H50/20G06Q10/04C12Q1/6886C12Q1/6869C12Q2600/154C12Q2600/118G06F18/2415G06F18/24323C12Q2537/165
Inventor 应建明李卫华邵阳汪笑男刘凯华郭蕾赵宏
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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