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TCR-T cell for killing tumors as well as preparation method and application of TCR-T cell

A technology of TCR-T cells, which is applied in the field of TCR-T cells that kill tumors and its preparation, can solve the problems of inability to recognize, identify and analyze T cell tumor antigens, high technical difficulty, and complicated experimental procedures

Pending Publication Date: 2020-10-30
GUANGZHOU FINELMMUNE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the extremely complicated experimental process and high technical difficulty of the entire identification, it is still impossible to conduct systematic identification and analysis of tumor antigen recognition and analysis on T cells in a tumor tissue.
It also makes it impossible to quickly obtain T cells and TCRs that recognize tumor antigens from tumor tissues for treatment

Method used

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  • TCR-T cell for killing tumors as well as preparation method and application of TCR-T cell
  • TCR-T cell for killing tumors as well as preparation method and application of TCR-T cell
  • TCR-T cell for killing tumors as well as preparation method and application of TCR-T cell

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Embodiment Construction

[0024] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific examples. It is worth noting that, for the purpose of brevity and clarity, some conventional technical operation steps, reagents, and instruments are not described in detail in the following examples, but it should be understood that if there is no special description, these conventional technical operation steps, reagents , the instrument will be apparent to those of ordinary skill in the art.

[0025] The present invention will be further described below in conjunction with specific examples, and the advantages and characteristics of the present invention will become clearer along with the description. However, the examples are merely exemplary and do not limit the scope of the present invention in any way. Those skilled in the art should understand that the details and forms of the ...

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Abstract

The invention provides a TCR-T cell for killing tumors, which is characterized in that the TCR-T cell is a T cell carrying a tumor antigen TCR, TCR in the TCR-T cells is derived from any one or more of the following T cells: 1) CD4T cells for expressing one or more of genes such as TNFRSF18, CXCL13, TNFRSF4, TNFSF8, ENTPD1, ACP5, LAYN, TNFRSF9, CTLA4, CD200 and TIGIT in tumors; and 2) a CD8T cellfor expressing one or more of the genes of TNFRSF18, CXCL13, CXCR6, GALNT2, ENTPD1, ACP5, HAVCR2, LAYN, TNFRSF9, CTLA4 and CD109 in the tumor. The TCR-T cell provided by the invention can be effectively applied to treatment of tumors, especially immunotherapy.

Description

technical field [0001] The invention relates to the technical field of immunotherapy, in particular to a TCR-T cell for killing tumors and its preparation method and application. Background technique [0002] T cells recognize antigens presented by human leukocyte antigens (HLA) on the surface of target cells through the T cell receptor (TCR) on their surface, so as to directly attack and kill target cells. Traditional TCR-T cell therapy that recognizes tumor antigens is aimed at known tumor antigens, cloning TCRs that can recognize these known antigens, and clarifying their corresponding HLA subtypes. Then select patients who express the tumor antigen and HLA subtype at the same time, prepare TCR-T cells, and carry out reinfusion therapy. However, few tumor antigens are currently known, and these antigens are only expressed in a small proportion of patients. Coupled with the need to express the corresponding HLA molecules at the same time, only very few patients can meet ...

Claims

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Application Information

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IPC IPC(8): C12N5/10A61K39/00A61P35/00C12Q1/02
CPCC12N5/0636A61P35/00G01N33/505C12N2510/00A61K2039/5156C12N2503/02G01N2500/10G01N2333/7051A61K39/0011A61K2039/5158A61K39/4611A61K39/4644Y02A50/30
Inventor 刘海平李翔李游卞超超
Owner GUANGZHOU FINELMMUNE BIOTECHNOLOGY CO LTD
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