Hemodialysis membrane and preparation method thereof

A technology of hemodialysis and membrane casting solution, which is applied in the field of hemodialysis membrane and its preparation, can solve the problems of complex process, difficulty in large-scale production, and performance degradation, and achieve the effects of cost reduction, strong hydrophilicity, and simple preparation method

Inactive Publication Date: 2020-10-30
中山图微新材料研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to solve this problem, some hydrophilic additives are often added or some complex modification methods are used to improve the hydrophilicity and hemocompatibility of the dialysis membrane in the actual application process. Although the use of additives can improve the dialysis membrane Hydrophilic and blood compatibility, but because it is only a simple blending modification, the additives will gradually lose during use, resulting in a decline in performance and even side effects; although the performance can be maintained for a long time through complex modification methods, However, the complexity of the process makes it difficult to produce on a large scale, which increases the production cost of the hemodialysis membrane

Method used

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  • Hemodialysis membrane and preparation method thereof
  • Hemodialysis membrane and preparation method thereof
  • Hemodialysis membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A hemodialysis membrane prepared by the following method:

[0031] (1) Add 5g of 4,4'-dihydroxydiphenyl ether polysulfate (molecular weight: 50kDa) into 28.3g of N-methylpyrrolidone solution, stir and dissolve at 80°C, and then let it stand in a drying oven at 60°C. Degassing to obtain a uniform casting solution with a solid content of 15%;

[0032] (2) Pour the film-casting liquid onto a clean and smooth glass plate, scrape the film with a scraper to coat evenly, and after 30 seconds of natural volatilization, immerse the glass plate in methanol for a coagulation bath, and continue to place the film after the film falls off automatically. Soak it in deionized water for 24 hours.

[0033] Wherein, the structural formula of 4,4'-dihydroxydiphenyl ether type polysulfate is:

[0034]

[0035] After testing, the pure water flux of the hemodialysis membrane prepared in Example 1 is 122 L m - 2 h -1 · bar -1 , the contact angle is 69°, when separating and concentratin...

Embodiment 2

[0037] A hemodialysis membrane prepared by the following method:

[0038] (1) Add 5g of 4,4'-dihydroxydiphenyl ether type polysulfate (molecular weight: 70kDa) to 28.3g of N-methylpyrrolidone solution, heat and stir at 80°C to dissolve, then put it in a drying oven at 60°C, Degassing to obtain a uniform casting solution with a solid content of 15%;

[0039] (2) Pour the film-casting liquid onto a clean and smooth glass plate, scrape the film with a scraper to coat evenly, and after 30 seconds of natural volatilization, immerse the glass plate in methanol for a coagulation bath, and continue to place the film after the film falls off automatically. Soak it in deionized water for 24 hours.

[0040] Wherein, the structural formula of 4,4'-dihydroxydiphenyl ether type polysulfate is:

[0041]

[0042] After testing, the pure water flux of the hemodialysis membrane prepared in Example 2 is 142L m - 2 h -1 · bar -1 , the contact angle is 59°, when separating and concentratin...

Embodiment 3

[0044] A hemodialysis membrane prepared by the following method:

[0045] (1) Add 5g of 4,4'-dihydroxydiphenyl ether type polysulfate (molecular weight: 100kDa) into 28.3g of N-methylpyrrolidone solution, heat and stir at 80°C to dissolve, then place it in a drying oven at 60°C, Degassing to obtain a uniform casting solution with a solid content of 15%;

[0046] (2) Pour the film-casting liquid onto a clean and smooth glass plate, scrape the film with a scraper to coat evenly, and after 30 seconds of natural volatilization, immerse the glass plate in methanol for a coagulation bath, and continue to place the film after the film falls off automatically. Soak it in deionized water for 24 hours.

[0047] Wherein, the structural formula of 4,4'-dihydroxydiphenyl ether type polysulfate is:

[0048]

[0049] After testing, the hemodialysis membrane membrane pure water flux that embodiment 3 makes is 156L m - 2 h -1 · bar -1 , the contact angle is 59°, when separating and con...

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Abstract

The invention discloses a hemodialysis membrane, the hemodialysis membrane is prepared by taking 4, 4 '-dihydroxy diphenyl ether type polysulfate as a membrane forming material to prepare a membrane casting liquid through a phase conversion method, the structural formula of the 4, 4'-dihydroxy diphenyl ether type polysulfate is shown in the specification, and the molecular weight is 50-100kDa. Thehemodialysis membrane has relatively large water flux and relatively high protein rejection rate, has permanent hydrophilicity, is simple in preparation method, and does not need to additionally adda modification additive in the preparation process.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hemodialysis membrane and a preparation method thereof. Background technique [0002] Hemodialysis is an important way of renal replacement therapy for patients with acute and chronic renal failure. It drains the blood from the human body to the outside of the body, purifies the blood through a dialyzer, and returns the purified blood to the human body. Hemodialysis membrane uses the principle of semi-permeable membrane, with the help of the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane, to remove toxins and retain excess water in the body, and at the same time replenish the substances needed in the body, and maintain electrolytes and purpose of acid-base balance. [0003] At present, blood filtration membranes commonly used in dialysis are mainly divided into cellulose-based membranes and synthetic polymer membranes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/66B01D69/02B01D67/00
CPCB01D67/0011B01D67/0013B01D69/02B01D71/66B01D2325/28B01D2325/36
Inventor 马醒宇周云斌曾能
Owner 中山图微新材料研究有限公司
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