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Medical ultrasonic patch and preparation method thereof

A patch and ultrasound technology, applied in the field of biomedicine, can solve problems such as product stability changes and affecting image quality.

Inactive Publication Date: 2020-10-30
高海玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, under the action of ultrasonic waves, components such as hydroxycellulose and alginate will degrade to form free radicals, causing chain scission and cross-linking of polymers, foam and color changes, and viscosity and mechanical properties of polymer products also occur. changes, resulting in changes in product stability that affect image quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A medical ultrasonic patch, characterized in that, by mass percentage, it consists of the following components: 6-(chloromethyl)uracil / 2-(chloromethyl)allyl-trimethylsilane co-modified Hyperbranched chitosan 7%, λ-carrageenan 1%, zeatin 0.1%, citronellyl methyl crotonate 0.5%, azobisisobutylamidine hydrochloride 0.01%, mallow glycosides chloride 0.2%, glycerin 0.8%, and deionized water as the balance.

[0021] The preparation method of described 6-(chloromethyl) uracil / 2-(chloromethyl) allyl-trimethylsilane co-modified hyperbranched chitosan, comprises the steps: 6-(chloromethyl) ) uracil, 2-(chloromethyl)allyl-trimethylsilane, and hyperbranched polychitosan were added to N,N-dimethylformamide, stirred and reacted at 40°C for 4 hours, and then rotated to evaporate Remove N, N-dimethylformamide, obtain described 6-(chloromethyl) uracil / 2-(chloromethyl) allyl-trimethylsilane co-modified hyperbranched polychitosan; The mass ratio of -(chloromethyl)uracil, 2-(chloromethyl...

Embodiment 2

[0024] A medical ultrasonic patch, characterized in that, by mass percentage, it consists of the following components: 6-(chloromethyl)uracil / 2-(chloromethyl)allyl-trimethylsilane co-modified Hyperbranched polychitosan 8%, λ-carrageenan 1.5%, zeatin 0.15%, citronellyl methyl crotonate 0.7%, azobisisobutylimidazoline hydrochloride 0.012%, malva glycosides chloride 0.25%, glycerin 1%, and deionized water as the balance.

[0025]The preparation method of described 6-(chloromethyl) uracil / 2-(chloromethyl) allyl-trimethylsilane co-modified hyperbranched chitosan, comprises the steps: 6-(chloromethyl) ) uracil, 2-(chloromethyl) allyl-trimethylsilane, and hyperbranched polychitosan were added to N-methylpyrrolidone, stirred and reacted at 45°C for 4.5 hours, and then rotated to remove N-methylpyrrolidone ylpyrrolidone to obtain the 6-(chloromethyl) uracil / 2-(chloromethyl) allyl-trimethylsilane co-modified hyperbranched polychitosan; the 6-(chloromethyl) uracil , 2-(chloromethyl) al...

Embodiment 3

[0028] A medical ultrasonic patch, characterized in that, by mass percentage, it consists of the following components: 6-(chloromethyl)uracil / 2-(chloromethyl)allyl-trimethylsilane co-modified Hyperbranched polychitosan 9%, λ-carrageenan 2%, zeatin 0.2%, citronellyl methyl crotonate 0.7%, azodiisopropylimidazoline 0.015%, and malvaloside chloride 0.3% , glycerin 1.1%, and the balance is deionized water.

[0029] The preparation method of described 6-(chloromethyl) uracil / 2-(chloromethyl) allyl-trimethylsilane co-modified hyperbranched chitosan, comprises the steps: 6-(chloromethyl) ) uracil, 2-(chloromethyl) allyl-trimethylsilane, and hyperbranched polychitosan were added to N-methylpyrrolidone, stirred and reacted at 50°C for 5 hours, and then rotated to remove N-methylpyrrolidone ylpyrrolidone to obtain the 6-(chloromethyl) uracil / 2-(chloromethyl) allyl-trimethylsilane co-modified hyperbranched polychitosan; the 6-(chloromethyl) uracil , 2-(chloromethyl) allyl-trimethylsila...

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Abstract

The invention discloses a medical ultrasonic patch, which is characterized by being composed of the following components (by mass): 7 to 11 percent of hyperbranched chitosan polysaccharideco co-modified by 6-(chloromethyl) uracil / 2-(chloromethyl) allyl-trimethylsilane, 1 to 3 percent of lambda-carrageenan, 0.1 to 0.3 percent of zeatin, 0.5 to 1 percent of citronellyl methylcrotonate, 0.01 to 0.02percent of a water-soluble initiator, 0.2 to 0.4 percent of malvidin chloride, 0.8 to 1.5 percent of glycerinum and the balance of deionized water. The invention further discloses a preparation methodof the medical ultrasonic patch. The medical ultrasonic patch disclosed by the invention is convenient and sanitary to use, easy to accept by a patient, high in ultrasonic image quality, reliable indisinfection and sterilization effect, free of corrosion to a probe, stable in physicochemical property, capable of effectively preventing cross infection and relatively good in skin nourishing effect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a medical ultrasonic patch and a preparation method thereof. Background technique [0002] Life is a long road, life, death, illness, and old age are natural laws. As people age, the pace of life accelerates, and the pressure from life and work increases, more and more people are suffering from diseases. In order to reduce the suffering of patients and reduce the physical pain and economic burden brought by diseases to patients, it is particularly important to carry out accurate diagnosis and targeted treatment of diseases, which in turn depend on accurate physiological or tissue structure data and morphology. Ultrasound diagnosis is an effective means to obtain accurate physiological or tissue structure data and morphology. It refers to a non-invasive examination method that uses the principle of ultrasound to judge the physical characteristics, morphological structure, and ...

Claims

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Application Information

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IPC IPC(8): A61K49/22
CPCA61K49/222
Inventor 高海玲史振英
Owner 高海玲
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