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Compounds and applications for the diagnosis of polycystic ovary syndrome

A polycystic ovary and syndrome technology, applied in the field of biomedicine, can solve problems such as high cost and complex diagnosis, and achieve the effect of reducing detection cost, simple and rapid diagnosis, and good diagnostic value

Active Publication Date: 2022-07-12
SUN YAT SEN UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

[0010] Aiming at the deficiencies of the prior art, the present invention aims to provide a compound for the diagnosis of polycystic ovary syndrome and its application, hoping to solve the clinical problems of complicated diagnosis and high cost in the prior art

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  • Compounds and applications for the diagnosis of polycystic ovary syndrome
  • Compounds and applications for the diagnosis of polycystic ovary syndrome
  • Compounds and applications for the diagnosis of polycystic ovary syndrome

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Embodiment

[0028] In the present invention, the Rotterdam Consensus (2003 version) is used as the criterion for screening the included objects, and there are 51 participants, including 26 polycystic ovary syndrome patients and 25 healthy people.

[0029] Specifically, 10 mL of urine mid-sample samples were collected from the participants when they urinated for the first time in the morning and immediately stored in a -80°C refrigerator until analysis. During the analysis, 50 μL of urine samples were taken out, and 200 μL of ice water was added and vortexed for 2 min to fully mix, followed by sonication for 2 min, and finally centrifuged at 4°C and 13000 rpm for 10 min. MS for off-target metabolomic analysis. Data were collected with MassLynx V4.1 software and imported into Progenesis QI V2.0 software for background noise removal, peak alignment and compound identification.

[0030] Then based on SIMCA V14.1 software, multivariate statistical analysis was performed on the data and an ort...

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Abstract

The invention discloses a compound used in the diagnosis of polycystic ovary syndrome. The compound is one of androsterone glucuronide or sphingomyelin (d17:1 / 24:1), or the compound is Combination of androstone glucuronide with sphingomyelin (d17:1 / 24:1). The beneficial effect of the present invention is that the non-target metabolomics research of polycystic ovary syndrome urine is carried out by ultra-high pressure liquid phase tandem time-of-flight mass spectrometry, and androsterone glucuronide, sphingomyelin lipid (d17:1 / 24: 1) and their combination have better diagnostic value for polycystic ovary syndrome. The purpose of simple and rapid diagnosis of polycystic ovary syndrome is achieved, and the detection cost is reduced at the same time.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound for diagnosis of polycystic ovary syndrome and its application. Background technique [0002] Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder. [0003] According to epidemiology, its prevalence in women of childbearing age is 5% to 20%. The clinical features of polycystic ovary syndrome mainly include hyperandrogenemia, menstrual disorders and polycystic ovaries. In addition, polycystic ovary syndrome patients are often accompanied by infertility, obesity, insulin resistance, type 2 diabetes or cardiovascular disease, which seriously affects the lives of patients and their families, and brings a huge economic burden to the society. [0004] At present, there are three main methods for analyzing polycystic ovary syndrome: [0005] 1. The Rotterdam Consensus (2003 edition), which requires at least two of the following three conditions...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/86C07J1/0011C07F9/113
Inventor 谢智勇杨占东叶思敏
Owner SUN YAT SEN UNIV
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