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Application of interleukin 2 for treatment of chronic spontaneous urticaria

A technique for urticaria and spontaneous urticaria, applied in the field of application of interleukin 2 for the treatment of chronic spontaneous urticaria, which can solve the problems of uncertain curative effect of irradiation, limited clinical application, unbearable patients, etc., and achieves symptoms of wheal and itching Relief, reduction of attack frequency, economical effect

Active Publication Date: 2020-10-27
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

IVIG and omalizumab belong to biological agents. Although they have achieved definite curative effect, because of the high price and the fact that the disease cannot be cured, a considerable proportion of patients cannot afford this type of therapy
The curative effect of ultraviolet radiation is uncertain, and patients need to frequently go to large hospitals with equipment to receive phototherapy, which brings high cost of lost time and is inconvenient, which greatly limits clinical application

Method used

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  • Application of interleukin 2 for treatment of chronic spontaneous urticaria
  • Application of interleukin 2 for treatment of chronic spontaneous urticaria
  • Application of interleukin 2 for treatment of chronic spontaneous urticaria

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Peng Moumou, female, 49 years old, went to the Dermatology Clinic of the Second Xiangya Hospital of Central South University on October 17, 2019 due to "repeated welts and itching for 2 years". The patient's self-report showed that the hands were slightly itchy at each outbreak, and after a few minutes, the whole body had wheals and pruritus. Once injected "Siqikang" for 45 days, there was no obvious improvement. Oral administration of "Cetirizine Tablets" 10mg qod in the past six months can control the symptoms, but when the drug is stopped, the onset occurs at night the next day.

[0042] The urticaria activity score (UAS7) at the first visit was 25 points. After completing the ASST examination, the result was positive. Combined with the disease process and medical history, the diagnosis was "chronic spontaneous urticaria". To maintain the dose of the original antihistamine, and add "human recombinant interleukin 2" 1.0MIU qod, intramuscular injection. After 2 injec...

Embodiment 2

[0044] Yang Moumou, male, 48 years old, went to the Dermatology Clinic of the Second Xiangya Hospital of Central South University on March 23, 2019 due to "repeated welts for more than one year". Each attack was dominated by wheals on the lower extremities, which occurred once at night and gradually subsided during the day. It could be controlled by taking "fexofenadine 60mg qn+rupatadine 10mg qod", and the attack occurred immediately after stopping the drug.

[0045] According to the patient's disease process and medical history, he was diagnosed as "chronic spontaneous urticaria", and the urticaria activity score (UAS7) was 16 points at the time of treatment. On the basis of maintaining the dose of the original antihistamine, "human recombinant Interleukin 2" 0.5MIUqod, after 7 intramuscular injections, the symptoms basically subsided, no medication was needed, and daily itching wheals lasted for 5 months without recurrence.

[0046] In September 2019, the patient reappeared...

Embodiment 3

[0048] Hu, female, 29 years old, went to the Dermatology Department of the Second Xiangya Hospital of Central South University on October 31, 2019 due to "wheals all over the body and itching for more than three months". The patient reported that the onset of the disease began 10 months after delivery. Once served "loratadine" 10mg qod, basically no attack, but every day after stopping the drug. Recently, the drug has been stopped for more than a week, and attacks occur every day and night, which seriously affects sleep and life. There are large red wheals during the outbreak, ranging in size, and many wheals are fused with each other.

[0049] Oral antihistamines had been stopped for more than a week at the first visit, the urticaria activity score (UAS7) was 22.5 points, and the chronic urticaria quality of life scale (CU-Q2oL) score was 66 points; after completing the ASST examination, the result was positive, Combined with the disease process and medical history, the dia...

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Abstract

The invention belongs to the field of medicine preparation, and particularly discloses application of low-dose interleukin 2 in medicine for treating chronic spontaneous urticaria. The low-dose recombinant human interleukin 2 is innovatively injected to the subcutaneous or intramuscular part of a patient suffering from chronic spontaneous urticaria, the severity and frequency of erythema and whealattack of the patient suffering from chronic spontaneous urticaria with poor treatment control of conventional antihistamine can be reduced, the pruritus degree can be reduced, or the medicine takingdose and medicine taking frequency of the antihistamine can be reduced, and the antihistamine can even be completely stopped from being taken for part of patients.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to an application of interleukin 2 for treating chronic spontaneous urticaria. [0002] technical background [0003] Chronic urticaria is a common disease in dermatology. It refers to recurrent transient (<24 hours) pruritic wheals on the skin and mucous membranes. The course of the disease lasts for more than 6 weeks, with or without angioedema. Chronic urticaria can usually be divided into chronic induced urticaria and chronic spontaneous urticaria (chronic spontaneous urticaria, CSU) [1] . Among them, chronic induced urticaria usually has certain definite inducing factors, such as cold stimulation, heat stimulation, sunlight exposure, local mechanical compression or mechanical stimulation, etc. When the patient is exposed to one of the above factors, it can induce wheal and itching On the contrary, CSU has no definite triggering factors, and patients can repea...

Claims

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Application Information

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IPC IPC(8): A61K38/20A61K45/00A61P17/00A61P17/04
CPCA61K38/2013A61K45/00A61P17/00A61P17/04A61K2300/00
Inventor 陆前进龙海易万煜
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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