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Vitamin C sodium chloride injection as well as preparation method and application thereof

A technology for sodium chloride injection and vitamins, applied in the fields of alkali/alkaline earth metal chloride active ingredients, pharmaceutical formulas, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2020-10-23
HEBEI KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of vitamin C sodium chloride injection, to solve the problem of vitamin C and sodium chloride maintaining proper dosage in the injection;

Method used

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  • Vitamin C sodium chloride injection as well as preparation method and application thereof
  • Vitamin C sodium chloride injection as well as preparation method and application thereof
  • Vitamin C sodium chloride injection as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 A kind of preparation method of vitamin C sodium chloride injection

[0033] The present embodiment prepares 100L vitamin C sodium chloride injection, comprises the following steps carried out in sequence:

[0034] 1) After boiling water for injection for 30 minutes, cool to 30°C;

[0035] Take 70L (generally 60~80L, this example takes 70L) of water for injection into the preparation container, maintain 30 ℃ and pass through carbon dioxide for 10min to make it saturated, add 100g of sodium bisulfite, 100g of sodium formaldehyde sulfoxylate and 5g Disodium ethylenediaminetetraacetate, stirred at 30°C and fully dissolved to obtain solution A 1 .

[0036] 2) Solution A 1 Add 700g of vitamin C to the solution, stir to dissolve at 30°C, then slowly add 240g of sodium bicarbonate (referred to as T1), stir to dissolve at 30°C, fully dissolve and mix well to obtain solution B 1 .

[0037] 3) Solution B 1 Add 900g of sodium chloride to the solution, stir at 30...

Embodiment 2~9

[0041] Embodiment 2~9 A kind of vitamin C sodium chloride injection and preparation method thereof

[0042] Embodiments 2 to 9 are respectively a vitamin C sodium chloride injection and a preparation method thereof. Their steps are basically the same as those in Embodiment 1, except that the amount of raw materials and process parameters are different. See Table 1 for details:

[0043] Table 1 List of process parameters in Examples 2 to 9

[0044]

[0045]

[0046] The content of other parts of embodiment 2~9, is identical with embodiment 1.

Embodiment 10

[0047] Embodiment 10 A kind of content determination result of vitamin C sodium chloride injection

[0048] The vitamin C sodium chloride injection N1~N9 that embodiment 1~9 prepares contains vitamin C (C 6h 8 C 6 ) should be 90.0%~110.0% of the labeled amount. Containing sodium chloride (NaCl) should be 95.0%~105.0% of the marked amount, and the marked amount is calculated based on the amount of raw materials. Carry out the outward appearance, content of vitamin C and sodium chloride to measure, and concrete result is shown in Table 2:

[0049] Table 2 List of quality inspection results of vitamin C sodium chloride injection prepared in Examples 1 to 9

[0050]

[0051] It can be seen from Table 2 that the vitamin C and sodium chloride injections N1-N9 prepared in Examples 1-9 are colorless and clear, the content of vitamin C and sodium chloride all meet the standards, and all other inspection-related items are all qualified.

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Abstract

The invention belongs to the technical field of animal husbandry and veterinary medicine, and discloses a vitamin C sodium chloride injection as well as a preparation method and application thereof. Raw materials for preparing effective components of the injection include vitamin C, sodium chloride, sodium bicarbonate, an antioxidant, a complexing agent and water. The method comprises the following steps: introducing carbon dioxide into the water until saturation, sequentially adding the antioxidant, the complexing agent, the vitamin C, the sodium bicarbonate and the sodium chloride, performing dissolving, adjusting the pH value, fixing the volume, and performing filtering. The injection is used for treating / relieving animal scurvy. Through a large number of experiments, the vitamin C sodium chloride injection with a proper medicinal dosage applied to animals is obtained. The saturated carbon dioxide is introduced, and a certain amount of sodium bicarbonate is added, so that the pH value is kept stable, the vitamin C is effectively prevented from being oxidized, and the problem of maintaining proper doses of vitamin C and sodium chloride in the injection is solved. The injection issuitable for injection of animals suffering from scurvy.

Description

technical field [0001] The invention belongs to the technical field of animal husbandry and veterinary medicine, and relates to an animal injection and a preparation method thereof, in particular to a vitamin C sodium chloride injection, a preparation method and application thereof. Background technique [0002] Vitamin C (Vitamin C, Ascorbic Acid), also known as L-ascorbic acid, is a water-soluble vitamin with a structure similar to glucose. It is a polyhydroxy compound, and there are two adjacent enols in the 2nd and 3rd positions of the molecule Hydroxyl, easily dissociated to release H + , so acidic. Vitamin C has a strong reducing property and is easily oxidized to obtain dehydrovitamin C. This reaction is reversible, and vitamin C and dehydrovitamin C have the same physiological effects, but dehydrovitamin C continues to be oxidized to form diketone Gulonic acid, the reaction is irreversible and completely loses its physiological efficacy. Vitamin C injection is a v...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61K47/02A61P3/02A61P3/12A61K31/375
CPCA61K31/375A61K33/14A61K9/08A61K9/0019A61K47/02A61P3/02A61P3/12A61K2300/00
Inventor 李凤英郭艳玉赵素娟王伟光邢江盼
Owner HEBEI KEXING PHARMA
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