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Multi-level controllable assembly type fluorescent-magnetic bifunctional microsphere as well as preparation method and application thereof

An assembly-type, multi-level technology, applied in the preparation of microspheres, microcapsules, fluorescence/phosphorescence, etc., can solve the problems of uncontrollable size and poor chemical stability, and achieve high-efficiency co-assembly, good biocompatibility, and high efficiency. Performance without interfering with each other

Active Publication Date: 2020-10-20
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the problems of uncontrollable size and poor chemical stability of traditional multifunctional nanomaterials, the present invention provides a multi-level controllable assembly with fast superparamagnetic response, high fluorescence intensity, good biocompatibility, uniform size and stable performance Fluorescent-magnetic bifunctional microspheres

Method used

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  • Multi-level controllable assembly type fluorescent-magnetic bifunctional microsphere as well as preparation method and application thereof
  • Multi-level controllable assembly type fluorescent-magnetic bifunctional microsphere as well as preparation method and application thereof
  • Multi-level controllable assembly type fluorescent-magnetic bifunctional microsphere as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Dendritic mesoporous silica microsphere template (dSiO 2 )Synthesis:

[0047] Add 0.136 g triethanolamine (TEA), 0.76 g cetyltrimethylammonium bromide (CTAB), 0.4632 g sodium salicylate (NaSal), and 8 mL tetraethylorthosilicate (TEOS) to 50 mL centrifuge the solution in ultrapure water, and react with magnetic force in an oil bath at 80 °C for 2 h, wash the precipitate with absolute ethanol, and repeat this step twice; finally, add the precipitate to a mixture of 100 mL hydrochloric acid and 100 mL methanol solution, and magnetically stirred for 6 h, then the product was washed three times with absolute ethanol and dispersed in 200 mL ethanol to obtain the product dSiO 2 , and its TEM image is shown in figure 1 As shown in a, it can be seen that dSiO 2 It has a very obvious center-radial channel, which can provide a large space for the subsequent loading of functional nanoparticles;

[0048] (2) Preparation of magnetic carrier SI (dendritic mesoporous silicon sp...

Embodiment 2

[0060] (1) Dendritic mesoporous silica microsphere template (dSiO 2 )Synthesis:

[0061] Add 0.272 g triethanolamine (TEA), 1.52 g cetyltrimethylammonium bromide (CTAB), 0.9264 g sodium salicylate (NaSal), and 16 mL tetraethylorthosilicate (TEOS) to 100 mL centrifuge the solution in ultra-pure water with magnetic stirring in an oil bath at 80 °C for 2 h, wash the precipitate with absolute ethanol, and repeat this step twice; finally add the precipitate to a mixture of 200 mL hydrochloric acid and 200 mL methanol solution, and magnetically stirred for 6 h, then the product was washed three times with absolute ethanol and dispersed in 400 mL ethanol to obtain the product dSiO 2 , its SEM image is shown in figure 2 As shown in a, it can be seen that the dendritic mesoporous silicon sphere has a pore size of tens of nanometers, and its inner surface is almost completely accessible, providing a large space for the loading of functional nanoparticles;

[0062] (2) Preparation of...

Embodiment 3

[0073] (1) Dendritic mesoporous silica microsphere template (dSiO 2 )Synthesis:

[0074] Add 0.136 g triethanolamine (TEA), 0.76 g cetyltrimethylammonium bromide (CTAB), 0.4632 g sodium salicylate (NaSal), and 8 mL tetraethylorthosilicate (TEOS) to 50 mL centrifuge the solution in ultra-pure water and react with magnetic force in an oil bath at 80 °C for 2 h, wash the precipitate with absolute ethanol, and repeat this step twice; finally add the precipitate to a mixture of 200 mL hydrochloric acid and 200 mL methanol solution, and magnetically stirred for 6 h, then the product was washed three times with absolute ethanol and dispersed in 400 mL ethanol to obtain the product dSiO 2 ;

[0075] (2) Preparation of magnetic carrier SI (dendritic mesoporous silicon sphere / ferric oxide nanoparticle composite microsphere):

[0076] Take 15 mL of the above product and centrifuge to keep the precipitate, add it together with 0.72 g of iron triacetylacetonate and 60 mL of triethylene ...

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Abstract

The invention relates to the technical field of nano materials, and provides a preparation method of bifunctional microspheres, which are uniformly filled with multifunctional nano elements in a high-density manner and have good biocompatibility, uniform size and stable performance, in order to solve the problems that a traditional multifunctional nano material is uncontrollable in size, poor in chemical stability and incapable of realizing maximization of multiple functions. Mono-dispersed dendritic mesoporous silica microspheres are used as a growth template, and sequential assembly of two functional elements is realized. Firstly, ferric acetyl acetonate is used as an iron source, and Fe3O4 nano-particles grow in-situ in pore channels in the dendritic silica microspheres. Through sulfydryl-metal coordination, hydrophobic quantum dots are further assembled in pore channels of the dendritic mesoporous silica microspheres in a high-density manner, so that efficient co-assembly of the two nano-elements in a carrier is realized, and the properties do not interfere with each other. The microsphere is used as a labeling probe to be applied to a detection platform, and high-sensitivity and high-accuracy detection for measuring a target substance can be realized.

Description

technical field [0001] The invention relates to the technical field of advanced nanocomposite materials, in particular to a multi-level controllable assembled fluorescent-magnetic dual-functional microsphere and its preparation method and application. Background technique [0002] Multifunctional nanostructures composed of two or more functional components have emerged as a new class of materials with potential applications, which are designed based on the idea of ​​nanoscale integration of multiple discrete nanocomponents. Compared with single-functional nanomaterials, the advantage of this type of material is that it can present multimodal applications based on different materials inside it, with richer and more tunable optical, electronic and magnetic properties, and the formed composite structure It can effectively circumvent the limitations of single-functional nanomaterials. As one of the current hot topics in nanotechnology, multifunctional nanomaterials have been ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02G01N21/64
CPCB01J13/02G01N21/6428
Inventor 黄亮张雨星汪晶
Owner ZHEJIANG UNIV OF TECH
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