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New application of pyridone antifungal medicine in prevention and control of crop diseases

A disease control and antifungal technology, which is applied in the field of new applications of pyridone antifungal medicines as fungicides in the prevention and control of crop diseases, and can solve the problems that there are no research reports on ciclopirox amine and oxypirox

Pending Publication Date: 2020-10-20
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But up to now, also do not see the research report of ciclopirox olamine and oxypirox in the prevention and treatment of plant diseases

Method used

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  • New application of pyridone antifungal medicine in prevention and control of crop diseases
  • New application of pyridone antifungal medicine in prevention and control of crop diseases
  • New application of pyridone antifungal medicine in prevention and control of crop diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: Determination of indoor antifungal activity

[0011] Mycelia growth rate method: According to a certain concentration gradient, add the test compound into the medium that has been sterilized and cooled to about 50°C, mix well, and dilute the agent into a series of concentrations to prepare a drug-containing medium. Each petri dish Inoculate a bacterial dish (diameter d=5mm), and set 3 repetitions for each concentration; and use azoxystrobin as a control agent to determine the inhibitory activity of the compound on 6 kinds of plant pathogenic fungi. Cultivate at 25°C until the control colony covers more than 2 / 3 of the petri dish, measure the colony diameter (mm) of each concentration treatment by the cross method, calculate the growth inhibition rate of the drug on the mycelium, and use statistical software SAS8 for statistical analysis of differences .1 (Statistical Analysis System 8.1). The inhibitory effects of ciclopirox olamine and oxypirox on 6 kind...

Embodiment 2

[0012] Embodiment 2: Indoor antibacterial activity assay

[0013] Micro-broth dilution method was used: X. citri was inoculated in 20 mL of MH medium, and then placed in a constant temperature shaker at 37° C. for 12 hours at a rotational speed of 150 rpm. Take an appropriate amount of bacterial culture solution and use a microplate reader to measure the absorbance at 600nm, and use the culture solution without bacteria as a blank control. 600 0.1 is equivalent to a concentration of 1×10 8 cfu / mL, the bacterial suspension was diluted to a concentration of 1×10 with MH medium 6 cfu / mL bacterial solution, set aside.

[0014] Use a row gun to draw 50 μL of the diluted bacterial solution into a 96-well plate, and then add 50 μL of the compound solution in sequence. The blank control is the addition of the same volume of PBS solution, and the positive control is eclotriazole. Three replicates are set for each concentration. After the sample was incubated in a constant temperatur...

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Abstract

The invention discloses a new application of a pyridone antifungal medicine as a bactericide in prevention and treatment of crop diseases, wherein the pyridone antifungal medicine is ciclopirox olamine and piroctone olamine, and can be used for preventing and treating crop diseases caused by rhizoctonia solani, sclerotinia sclerotiorum, botrytis cinerea, fusarium graminearum, magnaporthe grisea, cotton fusarium oxysporum and citrus canker. According to the invention, ciclopirox olamine and piroctone olamine have excellent antibacterial effects on sclerotinia sclerotiorum, rhizoctonia solani, botrytis cinerea, fusarium graminearum, magnaporthe grisea, cotton fusarium wilt and citrus canker, the bactericidal effect is significantly higher than commercial bactericides azoxystrobin and bismerthiazol, and the pyridone antifungal medicine has potential application prospects in crop disease control.

Description

technical field [0001] The invention relates to the field of agricultural fungicides, and more specifically, relates to the new application of pyridone antifungal medicines as fungicides in the prevention and control of crop diseases. Background technique [0002] Plant diseases seriously threaten the healthy development of agriculture and food security. The annual grain loss caused by plant diseases has exceeded 11% of the output. For example, paddy fields in my country are affected by sheath blight, causing a loss of 6 million tons of grain every year, and wheat is affected by head blight, causing a 10% to 30% reduction in production every year. The serious occurrence of plant diseases, the development of resistance of pathogenic bacteria and the abuse of chemical fungicides have aggravated the resistance of plant pathogens to fungicides, seriously threatening environmental safety and human health. Therefore, the research and development of new pesticides with high effici...

Claims

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Application Information

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IPC IPC(8): A01N43/40A01P3/00A01P1/00
CPCA01N43/40
Inventor 刘映前张智军贺颖慧赵文斌吴天琳杜莎莎杨程杰
Owner LANZHOU UNIVERSITY
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