Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Prefilled syringe and method of manufacture

A syringe and pre-filled technology, applied in syringes, ampoule syringes, infusion sets, etc., can solve problems such as slow release of lidocaine, and achieve the effect of excellent dissolution rate

Active Publication Date: 2022-05-27
DAE HWA PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem with these formulations is the slow release of lidocaine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Prefilled syringe and method of manufacture
  • Prefilled syringe and method of manufacture
  • Prefilled syringe and method of manufacture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Comparative test of lidocaine release rate according to the method of adding lidocaine

[0052] 1. Experimental purpose

[0053] The release rates according to the method of adding lidocaine to the hyaluronic acid (hereinafter referred to as "HA") cross-linked composition were compared to confirm the stability.

[0054] 2. Test Substances and Preparation

[0055] 2.1 Test Substances

[0056] Table 1

[0057] category HA concentration (mg / mL) Lidocaine concentration (%) for mixing 24 0.03 for spray 24 10.0

[0058] 2.2 Preparation of test substances

[0059] According to the method of adding lidocaine hydrochloride, test substances were prepared as follows.

[0060] (1) Gel hybrid type

[0061] After dissolving 0.03 g of lidocaine hydrochloride in 100 mL of PBS, 2.4 g of cross-linked hyaluronic acid was added thereto, and swelling was performed to prepare a hydrogel.

[0062] (2) In-syringe spray type

[0063] ① Put 2.4 ...

Embodiment 2

[0096] Example 2: Comparison of Lidocaine Loading and Dissolution Rates Based on Syringe Material / Syringe Volume

[0097] In order to compare the loading rate and dissolution rate of lidocaine according to syringe material / syringe volume, experiments were carried out under the following conditions to determine the loading rate and dissolution rate of lidocaine.

[0098] 1) Syringe material: Cyclic Olefin Copolymer (COC)

[0099] 2) Syringe volume: 1mL, 3mL, 10mL

[0100]

[0101] -PBS solution, 37°C

[0102] - Lidocaine solution concentration: 10%

[0103] - Method: After spraying 3 times in a syringe, dry in a drying oven at 70°C

[0104] - Number of spray repetitions: based on 9

[0105] The loading and dissolution rates of lidocaine by syringe volume are shown in Tables 4 and 5 below.

[0106] Table 4 compares the loading rates of lidocaine solutions by syringe volume

[0107] category Lidocaine Concentration (mg / mL) COC 1mL 3.23 COC 3mL 7.27...

Embodiment 3

[0113] Example 3: Confirmation of the effect produced by the composition of the lidocaine spray solution

[0114] In order to confirm whether an injection could be produced according to the hyaluronic acid concentration of the lidocaine spray solution, lidocaine spray solutions were prepared in PBS according to the following concentrations and sprayed, and the results are shown in Table 7 below.

[0115] Table 7

[0116]

[0117] As can be seen from Table 7, when the concentration of hyaluronic acid was 0.1 (w / v)% or more and less than 1.0, it was confirmed that even if the concentration of lidocaine was the same, the injection could be prepared by appropriate spraying.

[0118] Then, according to the number of sprays of the lidocaine spray solution containing 0.1 and 0.5 (w / w)% of hyaluronic acid, the loading rate and the dissolution rate showing the desired spray effect of lidocaine were determined. The experimental conditions are as follows. The results are shown in Ta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The present invention relates to a method of manufacturing a prefilled syringe comprising a hyaluronic acid hydrogel containing a local anesthetic, and to a prefilled syringe manufactured thereby, and more particularly to a prefilled syringe Syringe and method of manufacture thereof, wherein local anesthetic (such as lidocaine) or pharmaceutically acceptable salt thereof is allowed to be adsorbed on the inner wall of the syringe, and then coated on the surface of the hydrogel, so that during operation or injection process Exhibiting excellent initial release of local anesthetics or pharmaceutically acceptable salts thereof, the syringe of the present invention can quickly exhibit anesthesia when injecting dermal fillers and the like even if it is transported and stored for a long time.

Description

technical field [0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims the benefit of Korean Patent Application No. 10-2017-0175282, filed with the Korean Intellectual Property Office on December 19, 2017, the entire contents of which are incorporated herein by reference. [0003] The present invention relates to a method of manufacturing a prefilled syringe containing a hyaluronic acid hydrogel and a local anesthetic, and more particularly, to a method that allows the local anesthetic to be adsorbed on the inner wall of the syringe and then coated on the hydrogel A pre-filled syringe and method of making the same, thereby exhibiting excellent initial release of lidocaine during handling or injection. Background technique [0004] The most common aesthetic signs of facial aging include visible skin wrinkles, deep nasolabial folds, tarsal lines, puppet lines, buccal commissures, and perioral wrinkles. These aging changes are usually treated by inje...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/167A61M5/28A61F2/00B65B3/00A61K9/00A61K8/73
CPCA61K31/167A61K2800/91A61Q19/08A61K8/735A61K8/042A61K8/42A61K31/445A61K31/245A61K31/46A61K31/47A61K31/24A61K9/0019A61K9/06A61K47/36A61M5/28A61F2/0059A61F2/0095B65B3/003A61K9/0024
Inventor 李智演宋寅范孙旼希李仁铉
Owner DAE HWA PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com