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Bone hemostatic material and preparation method thereof

A hemostatic material and selected technology can be used in pharmaceutical formulations, surgery, drug delivery and other directions, which can solve the problems of not promoting bone wound healing, affecting bone wound repair, and limiting clinical application, so as to improve bone repair effect and relieve discomfort. , Good hemostatic effect

Pending Publication Date: 2020-09-29
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] To sum up, many hemostatic materials for bone wounds are currently used in China, but their non-degradable properties limit their clinical application and increase foreign body reactions, affecting the repair of bone wounds.
Although there have been studies on absorbable bone wound hemostatic materials, there are still unresolved practical problems such as poor adhesion, failure to promote bone wound healing, and rapid degradation in vivo.

Method used

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  • Bone hemostatic material and preparation method thereof
  • Bone hemostatic material and preparation method thereof
  • Bone hemostatic material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0043] This implementation provides a bone hemostatic material. According to parts by weight, the bone hemostatic material in this embodiment is composed of 30 parts of poloxamer and 60 parts of sodium carboxymethyl cellulose, and the poloxamer is composed of Composed of Poloxamer 124 and Poloxamer 184 at a weight ratio of 1:1.

[0044] Further, this embodiment provides a method for preparing the above-mentioned bone hemostatic material, including the following steps:

[0045] 1) Select 30 parts of a mixture of Poloxamer 124 and Poloxamer 184 with a weight ratio of 1:1, and heat-melt it at 80°C to obtain a completely dissolved blend;

[0046]2) Select 60 parts by weight of sodium carboxymethyl cellulose with a particle size of 150 μm, and mix it with the blend solution described in step 1) by mechanical stirring. After molding, let it stand and cool at room temperature for 1.5 hours to obtain a wax Material;

[0047] 3) After packaging the waxy material described in step 2),...

Embodiment 2

[0049] This implementation provides a bone hemostatic material. According to parts by weight, the bone hemostatic material in this embodiment consists of 30 parts of sodium carboxymethylcellulose, 10 parts of poloxamer 407 powder and 20 parts of purified water.

[0050] On the other hand, this embodiment provides a method for preparing a bone hemostatic material, comprising the following steps:

[0051] 1) Blend 30 parts of sodium carboxymethylcellulose, 10 parts of poloxamer 407 powder and 20 parts of purified water, and mechanically stir to form a cement-like bone hemostatic material.

[0052] 2) The prepared cement-like bone hemostatic material is molded in a mold to obtain a block bone hemostatic material, which is packaged and used 60 Co ray sterilized to prepare the bone hemostatic material, which was sealed and stored at room temperature.

Embodiment 3

[0054] This embodiment provides a bone hemostatic material. According to parts by weight, the bone hemostatic material described in this embodiment consists of 20 parts of sodium carboxymethylcellulose, 20 parts of poloxamer 188 powder and 20 parts of a mass concentration of 5% aqueous solution of sodium silicate.

[0055] 1) Take 20 parts by weight of poloxamer 188 and 20 parts by weight of sodium carboxymethylcellulose, and mix them uniformly by mechanical stirring to prepare a blend powder. After the blend powder is packaged separately, use 60 Co ray sterilization;

[0056] 2) Separately package the sodium silicate aqueous solution with 20 parts by weight and 5% mass concentration, and use 60 Co ray sterilization.

[0057] 3) Combine and package the individually packaged blend powder and the aqueous solution of sodium silicate with a mass fraction of 20 parts to obtain a bone hemostatic material that can be prepared and used to promote new bone formation.

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Abstract

The invention discloses a bone hemostatic material. The bone hemostatic material is composed of poloxamer and a cellulose derivative. The bone hemostatic material in the invention has good adhesiveness, can effectively stop bleeding and promote healing of a bone injury part, can be degraded in the body, is free from immunogenicity and high in security, and can be ready to use.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a bone hemostatic material for craniocerebral surgery, orthopedics and orthopedic surgery and a preparation method thereof. Background technique [0002] Bone wound bleeding is the most common problem in craniocerebral surgery, orthopedics, and orthopedic surgery. Clinically, hemostatic materials are mainly used to fill the wound to achieve hemostasis. At present, clinically, bone wax composed of beeswax, paraffin, medical vaseline, lanolin, vegetable oil, etc. is mainly used to fill wounds, but these materials have poor biocompatibility, are difficult to be degraded and absorbed by the body, and are easy to remain and affect wound healing. question. In response to the above problems, researchers at home and abroad have begun to explore the possibility of using biomaterials or polymer materials instead of bone wax for bone wound hemostasis, and have achieved some ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/04A61L24/02A61L24/00
CPCA61L24/08A61L24/046A61L24/001A61L24/0042A61L24/02A61L24/0015A61L24/00A61L2400/04A61L2300/412A61L2300/23A61L2300/216A61L2300/104A61L2300/204C08L5/04C08L1/284C08L1/04C08L71/02A61L2430/02
Inventor 徐宝艳李艳婷田珍黄文涛
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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