Medicinal and edible composition with a hypoglycemic effect as well as preparation method and application thereof

A technology of medicine and food homology, composition, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve good effects

Active Publication Date: 2020-09-25
江西蔓三七健康科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of hypoglycemic drugs on the market. Most of these drugs are chemically or biosynthetized. Although the hypoglycemic effect is obvious, they also bring many side effects, and the high price is also prohibitive.

Method used

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  • Medicinal and edible composition with a hypoglycemic effect as well as preparation method and application thereof
  • Medicinal and edible composition with a hypoglycemic effect as well as preparation method and application thereof
  • Medicinal and edible composition with a hypoglycemic effect as well as preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0029] A preparation method of a medicinal and edible homologous composition with hypoglycemic effect, comprising the following steps:

[0030] Step 1): collect eucommia leaves as raw materials, dry and pulverize them, use water as the extraction solvent, the extraction temperature is 80°C, the ratio of solid to liquid is 1:10-20, stir and extract, filter, and combine the filtrates to concentrate under reduced pressure to 1 / 3 of the original solution 10. Add 4 times the amount of absolute ethanol, put it in the refrigerator, overnight, centrifuge to collect the supernatant, concentrate until it has no alcohol smell, add an equal amount of distilled water to ultrasonically disperse, add an equal volume of solvent for extraction, extract three times, and combine the extraction phases , concentrated to dryness to prepare Eucommia leaf extract;

[0031] Step 2): Collect the leaves of Keji japonica as the raw material, dry and pulverize them, use water as the extraction solvent, th...

Embodiment 1

[0035] Take 100g of eucommia leaves, dry and pulverize, use water as the extraction solvent, the extraction temperature is 80°C, the ratio of solid to liquid is 1:20, stir and extract, filter, combine the filtrate and concentrate it under reduced pressure to 1 / 10 of the original solution, add 4 times the amount of Absolute ethanol, put it in the refrigerator overnight, centrifuge to collect the supernatant, concentrate until there is no alcohol smell, add an equal amount of distilled water to ultrasonically disperse, add an equal volume of n-butanol for extraction, extract three times, combine the extract phases, concentrate to dryness preparation Obtain Eucommia leaf extract 2.35g, yield 2.35%, the liquid chromatogram of Eucommia extract is as follows: image 3 shown.

[0036] Take 100g of Mujira Yeke, dry and pulverize it, use water as the extraction solvent, the extraction temperature is 70°C, the ratio of solid to liquid is 1:20, stir and extract, filter, combine the filtr...

Embodiment 2

[0040] Take 100g of eucommia leaves, dry and pulverize, use water as the extraction solvent, the extraction temperature is 80°C, the ratio of solid to liquid is 1:10, stir and extract, filter, combine the filtrate and concentrate it under reduced pressure to 1 / 10 of the original solution, add 4 times the amount of Absolute ethanol, put it in the refrigerator overnight, centrifuge to collect the supernatant, concentrate until it has no alcohol smell, add an equal amount of distilled water to ultrasonically disperse, add an equal volume of dichloromethane / methanol for extraction, extract three times, combine the extract phases, and concentrate to 4.18g of eucommia leaf extract was obtained by dry preparation, the yield was 4.18%;

[0041] Take 100g of Algifolia Yeke, dry and pulverize it, use water as the extraction solvent, the extraction temperature is 70°C, the ratio of solid to liquid is 1:10, stir and extract, filter, combine the filtrate and concentrate it under reduced pre...

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Abstract

The invention discloses a medicinal and edible composition with a hypoglycemic effect as well as a preparation method and an application thereof. The composition is prepared by mixing extracts of eucommia ulmoides, lithocarpus litseifolius and gynura procumbens, and the preparation method comprises the following steps: (1) carrying out drying, crushing, sieving and the like on the raw material eucommia ulmoides, lithocarpus litseifolius and gynura procumbens to obtain eucommia ulmoides, lithocarpus litseifolius and gynura procumbens powder; (2) carrying out solvent extraction, alcohol precipitation, extraction and crystallization on eucommia ulmoides, lithocarpus litseifolius and gynura procumbens powder to obtain eucommia ulmoides, lithocarpus litseifolius and gynura procumbens extracts respectively; and (3) performing mixing on eucommia ulmoides, lithocarpus litseifolius and gynura procumbens extract according to a ratio of 1: 1: 1-1: 1: 3, and performing uniformly shaking to preparethe combined extract. The medicinal and edible composition produced in the invention can significantly reduce the glycemic index and postprandial blood sugar content of diabetes patients, has good prevention and treatment effects on complications caused by diabetes, and has significant social and economic benefits.

Description

technical field [0001] The invention belongs to the technical field of extraction and application of plant effective active ingredients, and in particular relates to a medicinal and edible homologous composition with hypoglycemic effect, its preparation method and application. Background technique [0002] Diabetes refers to a disease of glucose metabolism disorder caused by insufficient insulin secretion, insulin action disorder, glucose metabolism disorder, or a combination of the three. Its symptoms are polydipsia, polyphagia, polyuria and weight loss. Diabetes is one of the largest global health emergencies of the 21st century, with increasing prevalence worldwide, currently affecting 8.8% of adults. Diabetes can induce a variety of acute or chronic complications, such as cardiovascular and cerebrovascular diseases and diabetic nephropathy. Sustained disorders of glucose and lipid metabolism can lead to many diseases in the large and small blood vessels, microvessels, n...

Claims

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Application Information

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IPC IPC(8): A61K36/49A61P3/10A61P19/06
CPCA61K36/28A61K36/46A61K36/49A61K2236/331A61K2236/333A61P3/10A61P19/06A61K2300/00
Inventor 吴磊吴静胡居吾熊伟李雄辉韩怀志
Owner 江西蔓三七健康科技有限公司
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