Application of a kind of laver polysaccharide and preparation method of laver polysaccharide

A technology of seaweed polysaccharide and seaweed, applied in the field of medicine, can solve the problems such as no antidepressant effect of seaweed polysaccharide, and achieve the effect of promoting the level of hippocampal neurotrophic factor, wide range of materials and high safety.

Active Publication Date: 2022-03-11
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Up to now, there is no related literature report that laver polysaccharide has antidepressant effect

Method used

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  • Application of a kind of laver polysaccharide and preparation method of laver polysaccharide
  • Application of a kind of laver polysaccharide and preparation method of laver polysaccharide
  • Application of a kind of laver polysaccharide and preparation method of laver polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Hydrate alcohol lycolic solution Extraction of apricular acid solution polysaccharide

[0042] The method of preparing a method for preparing a seaweed polysaccharide, comprising the step of weighing the dried seaweed, 100 times after pulverizing, 85% ethanol heating at 75 ° C for 1 hour, filtration removal of alcohol soluble substances, repeating 3 times. The residue was washed twice with methanol and dried. The powder was extracted with 200 times distilled water at 95 ° C, then centrifuged at 8000 × g for 20 minutes, and then the centrifuge was concentrated to 1 / 3 of the original volume using a rotary evaporator. Then, sodium acetate and acetic acid were added to the supernatant to prepare 0.5 M acetate solution (pH 5.0), and then the final concentration of 42% ethanol (V / V) was added, and after 1 hour, the solution in the solution was removed. A precipitate, the regulatory filtrate ethanol final concentration was 60% (v / v). The second precipitate was collected at 10,...

Embodiment 2

[0045] Acino Acid Acid Polysaccharide Experiment

[0046] 1. Experimental animal male C57 / BL mouse purchased from Shanghai Slack Experimental Animal Center, weight 22-26g, 8 weeks; animals were placed in a cage of 320 × 180 × 160cm, 5 per cage, mouse adapt to the environment for a week The entire experiment was given free water eating, the ambient temperature was 22 ± 2 ° C, the relative humidity was 55 ± 5%, and 12 hours per day.

[0047] 2. Drug-formulated positive fluorvadetine is formulated into 20 mg / 10 ml of suspension in physiological saline; ibuic acid solution polysaccharide into three doses of solutions of 100 mg / ml, 200 mg / ml, 400 mg / ml.

[0048] 3, animal grouping and administration method mice were divided into 5 groups, 10 per group, respectively, model control group (physiological saline), positive fluorbitatin group (20 mg / kg), wastamic acid solution polysaccharide (100 mg / kg, 200 mg / kg, 400 mg / kg); administration was administered at a mouse weigh...

Embodiment 3

[0055] Chronic administration of purple acid polysaccharide

[0056] 1. Experimental animals with Example 2 experimental animals.

[0057] 2. Referring to the drug formulation of Example 2, see Example 2.

[0058] 3, animal grouping and administration method mice were divided into 6 groups, each group of 16, respectively: normal control group (physiological saline), normal-positive fluorfusstin group (20 mg / kg), normal-espouri acid polysaccharide Group (200 mg / kg); model control group (physiological saline), model - positive fluorflueth group (20 mg / kg), model-purple acid solution polysaccharide group (200 mg / kg), weight 10ml / kg according to mice Gastric administration, administration once a day, lasting 28 days, then carry out sugar-water preference experiments and forced swimming experiments.

[0059] 4, chronic gentle stress model groups for a period of 8 weeks of low intensity stress, including: deprivation of food and water, lacquer 45 ° C, interval illumination, co...

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PUM

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Abstract

The invention discloses an application of laver polysaccharide, provides a new application of laver polysaccharide, and can use laver acid hydrolyzed polysaccharide as an antidepressant drug for drug production, or as an antidepressant functional food for food production, and has broad application prospects. The invention also provides a preparation method of the laver polysaccharide, which comprises extracting the laver acid hydrolyzed polysaccharide from the dried laver by water extraction, alcohol precipitation and acid hydrolysis, and the final yield of the laver acid hydrolyzed polysaccharide is more than 10%. The invention uses seaweed as a raw material, has a wide range of materials and is cheap in price, and as a food eaten for many years, seaweed has high safety and strong acceptability. The research found that the acid hydrolyzed polysaccharide of laver has good antidepressant effect.

Description

Technical field [0001] The present invention relates to the field of medical technology, and more particularly to the preparation and application of a seaweed polysaccharide. Background technique [0002] Depression, also known as depression disorders, the main clinical features are the continued emotional low, which is the main type of mood barrier. Depression mainly shows the park's recession, slow thinking, cognitive function damage, low mood, and even pessimism, there is suicide behavior, suicide rate is 10% ~ 17%, with great harm, high form and recurrence rate. At present, the etiology and pathogenesis of depression is unclear. Relevant scholars have proposed a variety of hypothesis that biological, psychological and social environmental factors are involved in the pathogenesis of depression. Drugs are the main means of clinical treatment of depression, but more or less have a disadvantage of treatment effect (less efficient than 70%), side effects. In order to treat depress...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P25/24A23L33/125C08B37/00
CPCA61K31/715A61P25/24A23L33/125C08B37/0003C08B37/006A23V2002/00A23V2200/322
Inventor 易立涛李成付刘青
Owner HUAQIAO UNIVERSITY
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