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Artificial skin

A technology of artificial skin and dermis layer, applied in the field of artificial skin, can solve the problems of poor general state of burn patients, easy to cause infection, etc., and achieve the effect of shortening skin healing time, promoting survival and expansion, and improving life-saving rate.

Pending Publication Date: 2020-09-25
福建华民生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the poor general condition of patients with extensive burns can easily lead to infection

Method used

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Examples

Experimental program
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Effect test

Embodiment

[0020] An artificial skin is composed of an epidermis and a dermis, the epidermis is an antibacterial silicone film with enhanced strength, and the dermis is a three-dimensional porous structure composed of denatured collagen and fibrous collagen. Its concrete preparation steps are as follows:

[0021] 1) Preparation of the skin layer: After adding 10wt% silicon nitride powder to the raw material of silicone rubber, mix the two evenly, spread the film evenly on the surface of the flat plate to form a 200μm thick film, and then paste the net-shaped polyester fiber to form a strength reinforcement antibacterial silicone membrane;

[0022] 2) Preparation of dermis layer: After dissolving atelopeptide bovine collagen, heat it at 90°C for 60 minutes to prepare denatured collagen; Heating for 60 minutes and filtering to obtain fibrous collagen; uniformly mix the prepared denatured collagen and fibrous collagen at a weight ratio of 1:4, freeze-dry at a vacuum degree below 0.05 Torr,...

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Abstract

The invention discloses novel artificial skin. The artificial skin is composed of an epidermal layer and a corium layer, wherein the epidermal layer is a strength-reinforced antibacterial silica gel film, and the corium layer is of a three-dimensional porous structure composed of denatured collagen and fibrosis collagen. The artificial skin provided by the invention has a good antibacterial effect, can be used together with autologous reticular skin grafting to realize one-step treatment transplantation, so that the operation time is greatly shortened, secondary operation treatment is avoided,and the skin repair time can also be shortened, and therefore, the artificial skin has high application value and market popularization prospect.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a novel artificial skin. Background technique [0002] The skin is the largest organ of the human body. It not only plays an important role in protecting the stability of the internal environment of the body, resisting external stimuli and pathogen invasion, but also has functions such as water retention, secretion, excretion, sensation, temperature regulation and immunity. When a large area of ​​skin is damaged due to accidental burns, skin ulcers, etc., it is difficult for the body to maintain its original shape and function, which easily leads to loss of body fluids and invasion of external bacteria. If the skin is not protected in time, it will cause shock and threaten the life of the patient. To solve this problem, people usually adopt artificial skin to protect patients such as burns. [0003] Most of the artificial skins currently used have an epidermis and a d...

Claims

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Application Information

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IPC IPC(8): A61F2/10
CPCA61F2/105
Inventor 林孔华陈建凤
Owner 福建华民生物科技有限公司
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