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Drug repositioning method for COVID-19 treatment drug and application thereof

A technology for drug treatment and relocation, which can be used in drug reference, medical data mining, computer-aided medical procedures, etc., and can solve problems such as prodrug screening.

Pending Publication Date: 2020-09-22
DALIAN UNIV OF TECH
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Problems solved by technology

However, no matter how high the throughput of the high-throughput screening method is, there is a certain limit. Only a small number of drugs can be screened, and the screening results will be affected by factors such as the chemical properties and stability of the drug, and it is not suitable for previous screening. Disadvantages of drug screening

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  • Drug repositioning method for COVID-19 treatment drug and application thereof
  • Drug repositioning method for COVID-19 treatment drug and application thereof
  • Drug repositioning method for COVID-19 treatment drug and application thereof

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Embodiment Construction

[0032]The present invention is described below in conjunction with accompanying drawing and specific embodiment:

[0033] figure 1 It is an overall flow chart of a data mining method for novel coronavirus therapeutic drugs of the present invention. Such as figure 1 As shown, a data mining method for new coronavirus treatment drugs, the method includes the following steps:

[0034] S1. Collect the report of the diagnosis and treatment plan of the new crown virus, and construct a data set of the treatment plan for the known new crown disease: the data related to the new crown virus comes from three aspects, 1. The report of the diagnosis and treatment of the new crown virus of the National Health and Medical Commission. 2. DrugBank and repoDB databases. 3. medRxiv, bioRxiv literature database. The data collection process includes the following steps: It is a necessary process to capture the diagnosis and treatment plan of the new coronavirus, because the data of the drug for...

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Abstract

The invention discloses a drug repositioning method for a COVID-19 treatment drug and application thereof. The method comprises the following steps: s1, collecting a COVID-19 diagnosis and treatment scheme report, and constructing a treatment scheme data set of known COVID-19 diseases; s2, expanding drug-disease-target point relationship data; s3, standardizing entity naming and constructing a network; s4, performing network representation and association degree calculation; and s5, sorting the potential therapeutic drugs. According to the method, the drug disease similarity and the similaritybetween the drug targets are considered, and meanwhile, the drug network structure similarity and the target network structure similarity are combined, so that the prediction accuracy of the drug target interaction relationship is improved. Potential drugs for treating COVID-19 diseases are mined on the basis of the constructed COVID-19 data set, and the potential drugs contributing to COVID-19 treatment in the drugs on the market can be effectively found.

Description

technical field [0001] The invention relates to the technical fields of biomedicine and data mining, in particular to a drug repositioning method for treating drugs for the novel coronavirus. Background technique [0002] Drug repositioning (also known as repurpose) has become a hot spot in the medical field and the public, involving research on new therapeutic purposes for existing drugs. The research and development of new drugs has the characteristics of long cycle, high cost and high risk, and it is often long and difficult. Drug repositioning, that is, the discovery of new indications for existing drugs, can effectively shorten the cycle, reduce costs, and avoid risks, and is becoming an important strategy for drug research and development. Therefore, how to achieve "new use of old drugs" and reduce the development cycle of new drugs has great theoretical and practical value for drug development. [0003] From the discovery of a drug to its approval for marketing, it ...

Claims

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Application Information

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IPC IPC(8): G16H70/40G16H50/70
CPCG16H70/40G16H50/70
Inventor 林鸿飞刘海峰
Owner DALIAN UNIV OF TECH
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