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Signal acquisition and processing method for antigen and antibody protein combined dynamic action process

A technology of action process and signal acquisition, applied in the direction of material inspection products, measuring devices, instruments, etc., can solve the problems of protein molecular activity influence, lack of sensitivity, high sample consumption, etc., to avoid low signal sensitivity, high signal acquisition sensitivity, Simple and fast effect

Inactive Publication Date: 2020-09-22
SOUTH CHINA UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this type of method has certain defects. This method relies on markers to generate detectable signals. It needs to go through steps such as labeling and multiple washings, which consumes a lot of samples, and the activity of protein molecules on the samples will also be affected. And The operation is complex and time-consuming
In addition, this method has certain requirements on signal strength, and lacks sufficient sensitivity for the detection of trace antigens

Method used

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  • Signal acquisition and processing method for antigen and antibody protein combined dynamic action process
  • Signal acquisition and processing method for antigen and antibody protein combined dynamic action process
  • Signal acquisition and processing method for antigen and antibody protein combined dynamic action process

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Embodiment

[0036] This embodiment discloses a signal collection and processing method for the dynamic interaction process of antigen and antibody protein binding, such as figure 1 As shown, for the protein markers present in the biological sample to be tested, first let it react with the corresponding protein for antigen-antibody specific binding reaction, and use the mechanical property measurement platform to measure the specific binding reaction between the antigen and the antibody protein during the dynamic interaction process. The signal is quantified, and the specific binding signal is converted into an identifiable quantitative signal; and then analyzed based on the quantitative signal to obtain the specific binding state of the antigen-antibody protein.

[0037] Among them, the protein marker can be either an antigen or an antibody. Similarly, the corresponding protein that reacts with the protein marker can also be an antigen or an antibody. Specifically, when the protein marker ...

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Abstract

The invention discloses a signal acquisition and processing method for an antigen and antibody protein combined dynamic action process. The method comprises: for protein markers in a tested biologicalsample, carrying out antigen-antibody specific binding reaction with the corresponding protein, carrying out quantitative processing on a specific binding signal generated in the antigen-antibody protein binding dynamic action process by utilizing a mechanical property measurement platform, and converting the specific binding signal into a recognizable quantitative signal; and analyzing on the basis of the quantitative signal to obtain the antigen-antibody protein specific binding state. According to the present invention, the specific binding signal of the antigen-antibody binding dynamic action process on the biological sample can be rapidly and accurately collected and processed.

Description

technical field [0001] The invention relates to the technical field of antigen-antibody binding, in particular to a signal collection and processing method for the dynamic process of antigen-antibody protein binding. Background technique [0002] In recent years, relevant detection technologies based on the biological characteristics of antigen-antibody specific binding reactions have been widely used in clinical diagnosis and basic research, such as cancer tissue cell detection and virus infection detection. The methods commonly used in these technologies to identify antigen-antibody binding signals are enzyme labeling, fluorescent labeling, etc., through enzymatic substrate coloring, or fluorescent signals, etc. to reflect the information of antigen-antibody specific binding, and these labels are determined by optical microscope or electron microscope observation The signal generated by the substance can realize the detection of the antigen. However, this type of method h...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/569G01N33/53G01Q60/24G01Q60/38
CPCG01N33/53G01N33/56966G01N33/56983G01N33/574G01Q60/24G01Q60/38
Inventor 黄义虹辛学刚余委玲钟嘉瑞杨晶晶刘天琪戴戈扬陈鑫洋叶文慧吴佳锜肖楚茵
Owner SOUTH CHINA UNIV OF TECH
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