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Application of taurolidine in preparation of anti-HIV virus drugs

A technology of taurolidine and virus, applied in the field of medicine, can solve problems such as anti-HIV and other problems that have not been found

Pending Publication Date: 2020-09-18
CHANGCHUN MAILING BIOLOGICAL ENG CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it has not been found that it can be used for anti-HIV

Method used

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  • Application of taurolidine in preparation of anti-HIV virus drugs
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  • Application of taurolidine in preparation of anti-HIV virus drugs

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Embodiment Construction

[0012] In order to better understand the essence of the present invention, the inactivation effect of taurolidine on human immunodeficiency virus HIV is detected at the cellular level. The following is an inactivated virus detection report of a taurolidine sample made by Wuhan Vilide Biomedical Co., Ltd.

[0013] 1. Experimental materials

[0014] 1.1 Tested samples:

[0015] The taurolidine is synthesized with reference to the synthesis method of CN101274921A, and is configured into a 2% taurolidine solution as a test sample.

[0016] 1.2 Cells: MT-4, human T cell leukemia cells, the culture conditions of MT-4 cells are: 37°C, 5% CO 2 cultured in a humidified incubator. The medium used was RPMI1640 medium containing 10% FBS, 100 U / mL penicillin and streptomycin (Beyond #ST488). When the cell density reaches 1×10 7 cells / mL, after the cell culture flask was left to stand, the supernatant of the medium was removed, subcultured at 1:5, and fresh medium was added.

[0017] ...

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Abstract

The invention relates to an application of taurolidine in preparation of anti-HIV virus drugs, and relates to the technical field of medicines. The new application of taurolidine is discovered for thefirst time, namely the application of taurolidine in inhibition of HIV virus or in preparation of HIV virus drugs. The safety of taurolidine to a human body is detected by clinical practice, the obvious drug effect of taurolidine on HIV virus is discovered, powerful theoretical basis and practical basis are provided for anti-HIV virus, and the taurolidine has development value and popularizationsignificance. According to the application, the inactivation effect of taurolidine on human immunodeficiency virus HIV is detected on a cellular level, and the inactivation efficiency is about 73%. The invention provides a new way for treatment of AIDS.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an application of taurolidine in the preparation of anti-HIV drugs. Background technique [0002] AIDS is a very harmful infectious disease caused by HIV infection. HIV is a virus that attacks the body's immune system. It takes the most important CD4 T lymphocytes in the human immune system as the main attack target, destroys the cells in large quantities, and makes the human body lose its immune function. Therefore, the human body is susceptible to various diseases, and malignant tumors can occur, with a high mortality rate. However, there is still a lack of effective drugs to cure HIV infection worldwide. [0003] The Chinese patents CN101274921A and CN101285813A disclose the chemical name of taurolidine: 4,4'-methylenebis-(tetrahydro-2H-1,2,4-thiadiazine)-1, 1,1′,1′tetroxide, the molecular formula is C 7 h 16 N 4 o 4 S 2 , the molecular weight is: 284.348, the shape ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61P31/18
CPCA61K31/549A61P31/18
Inventor 陈强赵喜伍严庆文卢伟晋国庆苏忠
Owner CHANGCHUN MAILING BIOLOGICAL ENG CO LTD
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